Apoptotic processes during mammalian preimplantation development

Fabian, Denis; Koppel, Juraj; Maddox-Hyttel, Poul

doi:10.1016/j.theriogenology.2004.11.022

Cited by 87 publications

(84 citation statements)

References 50 publications

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“…Cumulus cells have been reported to be in G0/G1 (Wakayama et al, 1998). The time of zygotic gene activation (ZGA) depends partially on the method applied to measure transcriptional activation and has not been reported for all species listed (Telford et al, 1990;Kanka, 2003;Fabian et al, 2005). The cloning efficiency is given as the percentage of reconstructed embryos that were transferred to recipients and gave rise to cloned animals alive at term.…”

Section: Dna Methylation and Ntmentioning

confidence: 99%

Mammalian nuclear transfer

Meissner

Jaenisch

2006

Developmental Dynamics

112

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During development, the genetic content of each cell remains, with a few exceptions, identical to that of the zygote. Differentiated cells, therefore, retain all the genetic information necessary to generate an entire organism (nuclear totipotency). Nuclear transfer (NT) was initially developed to test experimentally this concept by cloning animals from differentiated cells. It has, since then, been used to study the role of genetic and epigenetic alterations during development and disease. In this review, we highlight some of the milestones in mammalian NT reached in the 50 years after the first nuclear transplantations in frogs. We also address problems associated with mammalian nuclear transfer and provide a survey on current NT and stem cell technology. In the long term, nuclear transfer or alternative strategies aim to generate customized pluripotent cells, which would be invaluable to medical research and therapy. Developmental Dynamics 235: 2460 -2469, 2006.

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Section: Dna Methylation and Ntmentioning

confidence: 99%

Mammalian nuclear transfer

Meissner

Jaenisch

2006

Developmental Dynamics

112

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“…Apoptosis or programmed cell death in preimplantation embryos is a routine process by which the embryo eliminates abnormal or extraneous cells (for reviews see Hardy 1997, 1999, Jurisicova & Acton 2004, Fabian et al 2005. Studies demonstrated that in vivo-derived murine and porcine preimplantation embryos commonly do not show TUNEL-positive staining before the blastocyst stage (Long et al 1998, Kamjoo et al 2002.…”

Section: Glucose Metabolism and Apoptosismentioning

confidence: 99%

Glucose utilization and the PI3-K pathway: mechanisms for cell survival in preimplantation embryos

Riley¹,

Moley²

2006

Reproduction

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The maintenance of optimal glucose utilization during the preimplantation period is critical for embryo survival. A decrease in glucose transport during preimplantation development has been linked to the early steps of programmed cell death in these embryos. Decreased glucose transport is not thought to be simply a consequence of cell death, rather it is thought to be a trigger that can initiate the apoptotic cascade. Extensive apoptosis during the preimplantation period may manifest later in pregnancy as a malformation -or miscarriage, if cell loss is excessive. Phosphatidylinositol 3-kinase (PI3-K) is a known regulator of a number of physiologic responses including cellular proliferation, growth, and survival as well as glucose metabolism. Studies performed in other cell systems have demonstrated that the PI3-K pathway plays a critical role in maintaining glucose transport and metabolism. This review will present the current evidence that suggests that PI3-K is vital for preimplantation embryo survival and development. In addition, data demonstrating that PI3-K activity is important for glucose metabolism during this early developmental period will be discussed.

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“…Stwierdzane również w macicy, indukują rozrost endometrium oraz rozwój łożyska. W konsekwencji warunkują prawidło-wą implantację oraz dalszy rozwój zarodka (17,28). Lokalizacja receptorów IGF w macicy powiązana jest z funkcją, jaką pełnią w tym organie, a ich koncentracja uzależniona jest od fazy cyklu płciowego.…”

Section: Czynnik Wzrostu śRódbłonka Naczyniowego (Vascular Endotheliaunclassified

“…Obecne w nabłonku gruczołowym, brodawkach macicznych i warstwie mięśniowej u przeżuwaczy, kontrolują czynności wydzielnicze endometrium. Wykazują także miogenny wpływ na komórki matki i płodu (17,37,48). Oddziałując bezpośrednio na sam zarodek, pobudzają metabolizm komórkowy, wzrost i różnicowanie, a także hamują procesy apoptozy zarodkowej (36,37).…”

Section: Czynnik Wzrostu śRódbłonka Naczyniowego (Vascular Endotheliaunclassified

Relevant aspects of the influence of chosen growth factors on the activity of the female reproductive system

Woźna¹,

Rybska²,

Swierczewska³

et al. 2017

Medycyna Weterynaryjna

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*) Projekt został sfinansowany ze środków Narodowego Centrum Nauki przyznanych na podstawie decyzji DEC-2013/09/N/NZ5/0183. Woźna M., Rybska M., Świerczewska M., Jaśkowski J. M.Relevant aspects of the influence of chosen growth factors on the activity of the female reproductive system Summary The endometrium of the uterus is a highly dynamic structure in terms of its changes during the various stages of the sexual cycle. These changes are the result of cyclical fluctuations in the concentrations of steroid hormones and local factors of an auto -and paracrine -nature. This condition indicates that the causes of degenerative processes of the uterus must be sought not only in disorders of the hormonal profile and bacterial infections but also disorders at the molecular level. Factors that may play a key role in the formation and development of various pathologies of the female reproductive system include growth factors and their receptors (growth factors -GFs). Discussing these growth factors in the work may provide useful molecular markers that identify pathological conditions of the endometrium. Subject to expression in the endometrium, they are involved in the regulation of cell proliferation, migration and secretion of the glandular epithelium, they also regulate physiological and pathological angiogenesis, revealing strong pro-inflammatory effects. In this research, the authors present an overview of current scientific reports indicating that changes in the expression of studied factors, and thus disturbances in their effects, may constitute one of the causes of pathogenesis within the uterus in many animal species.

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Apoptotic processes during mammalian preimplantation development

Cited by 87 publications

References 50 publications

Mammalian nuclear transfer

Mammalian nuclear transfer

Glucose utilization and the PI3-K pathway: mechanisms for cell survival in preimplantation embryos

Relevant aspects of the influence of chosen growth factors on the activity of the female reproductive system

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