“…Diosgenin when used in the treatment of cervical cancer, it revealed that when dose‐dependent diosgenin was supplied, it halted the proliferation of cells with glycosidic derivatives which bring on necrosis by Hernández‐Vázquez et al. (2020). Fernández‐Herrera et al (2010), suggested that diosgenin had beneficial properties in hindering the cervical cancer CaSki cells, and it also had no negative effect on normal fibroblast and peripheral blood lymphocytes in the cervical region.…”
Section: Effect Of Bioactive Compounds Over Cancermentioning
confidence: 99%
“…This works by inducing apoptosis by suggesting glucose and rhamnose residues plays a central role in increasing cell death activity. Diosgenin affects the proliferative potential of non‐tumor lymphocytes to a reduced extent (Hernández‐Vázquez et al., 2020).…”
Section: Effect Of Bioactive Compounds Over Cancermentioning
confidence: 99%
“…The activation of cytochrome C in mitochondria bring forth caspase‐9 and apaf‐1, as in turn, activation of caspase‐3 or 6 or 7 would take place. The activation of caspase will provoke morphological changes in the process of cellular mechanism (Hernández‐Vázquezet al, 2020).…”
To endure respective research for cancer via common food ingredients has become more prominent with preferably minuscule toxicity. Spices are emerging as a new source of bioactive compounds which have the potential to cure cancer. Fenugreek is rich in diosgenin that has curative and preventive potency toward various cancers. Cancer is invading various cellular mechanisms by altering cellular receptors. Cancer falsifies healthy cells by altered cell receptors like p38, p53, mTOR, Akt, and PARP. Distinct stages of cancer development are triggered by various cellular mechanisms. Diosgenin helps in suppressing cancer mechanisms and induces programmed cell death. Diosgenin brought changes in treatment line of lung, breast, prostate, liver, and colon cancer. Apoptosis changes cytoplasmic different caspase pathways and triggers selected sequence for cancer cell line death. Cell death comprised of series of events carried out by metalloprotease caspase. The complex relationship among cancer, caspase, cell death, and cellular receptors is reviewed in this article in respect of diosgenin. The utilization of diosgenin in creating a bar for cancer, its triggering sites, and various ways to cause apoptosis of abnormal cells. This article focused on diosgenin, its role in the prevention of different cancer and cellular apoptosis throughout different pathways involved in complex interaction of bioactive compound‐cellular mechanism cancer.
Practical applications
The concept of curing diseases from daily routine food is quite old. Fenugreek is an excellent source of various bioactive compounds especially diosgenin. Diosgenin is steroidal sapogenin that cures various health issues including cancers. Cancer is one of the most life‐threating disease which can affect any cell, tissue, and organ in living system. Diosgenin is proved to be beneficial in terms curing cancer of various types but majorly include lung, liver, colon breast, and prostate. Cancer cure with diosgenin is providing a new base to the pharmaceutical and medical researchers to commence new and more specific journey of diosgenin. Diosgenin could alter cellular pathways that modify cell mechanism in way toward treating cancer. Cell mechanism mainly affected by the interaction of cell signals and cell different receptors that cause triggered cell death. This review article focused over various cancer and diosgenin effect in controlling different cellular pathways which include cellular signaling and cell death mechanism.
“…Diosgenin when used in the treatment of cervical cancer, it revealed that when dose‐dependent diosgenin was supplied, it halted the proliferation of cells with glycosidic derivatives which bring on necrosis by Hernández‐Vázquez et al. (2020). Fernández‐Herrera et al (2010), suggested that diosgenin had beneficial properties in hindering the cervical cancer CaSki cells, and it also had no negative effect on normal fibroblast and peripheral blood lymphocytes in the cervical region.…”
Section: Effect Of Bioactive Compounds Over Cancermentioning
confidence: 99%
“…This works by inducing apoptosis by suggesting glucose and rhamnose residues plays a central role in increasing cell death activity. Diosgenin affects the proliferative potential of non‐tumor lymphocytes to a reduced extent (Hernández‐Vázquez et al., 2020).…”
Section: Effect Of Bioactive Compounds Over Cancermentioning
confidence: 99%
“…The activation of cytochrome C in mitochondria bring forth caspase‐9 and apaf‐1, as in turn, activation of caspase‐3 or 6 or 7 would take place. The activation of caspase will provoke morphological changes in the process of cellular mechanism (Hernández‐Vázquezet al, 2020).…”
To endure respective research for cancer via common food ingredients has become more prominent with preferably minuscule toxicity. Spices are emerging as a new source of bioactive compounds which have the potential to cure cancer. Fenugreek is rich in diosgenin that has curative and preventive potency toward various cancers. Cancer is invading various cellular mechanisms by altering cellular receptors. Cancer falsifies healthy cells by altered cell receptors like p38, p53, mTOR, Akt, and PARP. Distinct stages of cancer development are triggered by various cellular mechanisms. Diosgenin helps in suppressing cancer mechanisms and induces programmed cell death. Diosgenin brought changes in treatment line of lung, breast, prostate, liver, and colon cancer. Apoptosis changes cytoplasmic different caspase pathways and triggers selected sequence for cancer cell line death. Cell death comprised of series of events carried out by metalloprotease caspase. The complex relationship among cancer, caspase, cell death, and cellular receptors is reviewed in this article in respect of diosgenin. The utilization of diosgenin in creating a bar for cancer, its triggering sites, and various ways to cause apoptosis of abnormal cells. This article focused on diosgenin, its role in the prevention of different cancer and cellular apoptosis throughout different pathways involved in complex interaction of bioactive compound‐cellular mechanism cancer.
Practical applications
The concept of curing diseases from daily routine food is quite old. Fenugreek is an excellent source of various bioactive compounds especially diosgenin. Diosgenin is steroidal sapogenin that cures various health issues including cancers. Cancer is one of the most life‐threating disease which can affect any cell, tissue, and organ in living system. Diosgenin is proved to be beneficial in terms curing cancer of various types but majorly include lung, liver, colon breast, and prostate. Cancer cure with diosgenin is providing a new base to the pharmaceutical and medical researchers to commence new and more specific journey of diosgenin. Diosgenin could alter cellular pathways that modify cell mechanism in way toward treating cancer. Cell mechanism mainly affected by the interaction of cell signals and cell different receptors that cause triggered cell death. This review article focused over various cancer and diosgenin effect in controlling different cellular pathways which include cellular signaling and cell death mechanism.
“…[ 85,86] Anti-tumour effects a. A set of diosgenin compounds should be considered as a promising scaffold for their abilities as anticancer and immunomodulatory agents.…”
Section: Health Benefits Key Points Referencementioning
Background
Diosgenin is an isospirostane derivative, which is a steroidal sapogenin and the product of acids or enzymes hydrolysis process of dioscin and protodioscin. Galactomannans are heteropolysaccharides composed of D-mannose and D-galactose, which are major sources of locust bean, guar, tara and fenugreek.
Methods
Literature survey was accomplished using multiple databases including PubMed, Science Direct, ISI web of knowledge and Google Scholar.
Results
Four major sources of seed galactomannans are locust bean (Ceratonia siliqua), guar (Cyamopsis tetragonoloba), tara (Caesalpinia spinosa Kuntze), and fenugreek (T.foenum-graecum). Diosgenin has effect on immune system, lipid system, inflammatory and reproductive systems, caner, metabolic process, blood system, blood glucose and calcium regulation. The most important pharmacological benefits of galactomannan are antidiabetic, antioxidant, anticancer, anticholinesterase, antiviral activities, and appropriate for dengue virus and gastric diseases.
Conclusions
Considering the importance of diosgenin and galactomannans, the obtained findings suggest potential of diosgenin and galactomannans as natural products in pharmaceutical industries.
“…Diosgenin can be used as the natural precursor to commercially synthesize most of the therapeutically useful steroidal drugs, including estrogen, progesterone, testosterone, and other sex hormones or corticosteroids [ 12 ]. However, in addition to this high synthetic relevance, diosgenin itself has the benefits of antiproliferative activity [ 13 ], ameliorates testicular damage [ 14 ], anticancer activity [ 15 , 16 ], anti-apoptotic effect [ 17 ], cardiovascular protective effect [ 18 , 19 ], immunomodulating activity [ 20 ], among others. Scheme 1 Chemical structures of diosgenin (DSG) and piperazine (PIP) …”
A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized. The solid form was prepared by liquid assisted grinding, slurry and crystallization methods. The cocrystal was characterized by powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, and structure determined by single crystal X-ray diffraction, the hydrogen bonds formed into fish bone structure along the [010] direction and all the molecules packed into 3D layer structure along a axis. After formation of cocrystal, the solubility of diosgenin was improved, and the solubility value in 0.2% SDS solution was approximately 1.5 times as large as that of the parent material.
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