Apoptotic events induced by a natural plastoquinone from the marine alga Desmarestia menziesii in lymphoid neoplasms

Santos-Pirath, Íris Mattos; Walter, Laura Otto; Maioral, Mariana Franzoni; Philippus, Ana Cláudia; Zatelli, Gabriele Andressa; Horta, Paulo Antunes; Colepicolo, Pio; Falkenberg, Miriam; Santos-Silva, Maria Cláudia

doi:10.1016/j.exphem.2020.05.003

“…34 Citbismine c and plastoquinone 3 are natural organic compounds present in floral plants and may change due to chemical reactions during ripening. 35 The high contents of myricetin 3-neohesperidoside and rutin in SH may be caused by the method of collecting SH (Figure S4D). The amount of decenedioic acid, a kind of fatty acid (FA), was twice the amount in MH than IMH.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The glucose oxidase was presumably secreted by the hypopharyngeal glands of bees . Citbismine c and plastoquinone 3 are natural organic compounds present in floral plants and may change due to chemical reactions during ripening . The high contents of myricetin 3-neohesperidoside and rutin in SH may be caused by the method of collecting SH (Figure S4D).…”

Section: Resultsmentioning

confidence: 99%

Molecular Mechanism of Mature Honey Formation by GC-MS- and LC-MS-Based Metabolomics

Sun

¹

,

Zhao

²

,

Wu

³

et al. 2021

J. Agric. Food Chem.

View full text Add to dashboard Cite

Honey maturity is an important factor in evaluating the quality of honey; however, there are few studies on the molecular mechanism of the formation of mature honey (MH). In this study, the different metabolites of stomach honey (SH), immature honey (IMH), and MH samples during the same rapeseed flower season were analyzed by an UPLC-QTOF-MS-based metabolomics approach. MH was found to have a distinct metabolic profile to IMH, and a total of 9 different metabolites were obtained, 3 of which, including decenedioic acid, were accumulated in MH. Decenedioic acid as a bee-originated fatty acid (FA) was further verified in rape, acacia, and jujube honey by GC-MS, making it a potential marker to discriminate IMH and MH (P < 0.01). Besides, MH showed higher FAs concentrations; in particular, 3 FAs were significantly richer in MH than IMH (P < 0.05). This study reveals the molecular mechanism from IMH to MH from a FA perspective.

show abstract

“…Yu et al showed that the blockage of GPER/ABCG2 signaling could be a potential target for enhancing the chemosensitivity of breast cancer patients [ 26 ]. Chen et al showed that RBP1 gene transfection could significantly reverse L5-induced increases in CASP3 [ 27 ], while overexpression of CASP3 has been shown to enhance chemosensitivity in multiple cancer cells, including breast cancer cells and hematological neoplastic cells [ 28 , 29 ]. This establishes a chemosensitivity inhibition role of RBP1.…”

Section: Discussionmentioning

confidence: 99%

Variation of PPARG Expression in Chemotherapy-Sensitive Patients of Hypopharyngeal Squamous Cell Carcinoma

Lian

¹

,

Tao

²

,

Chen

³

et al. 2021

View full text Add to dashboard Cite

Our previous study showed that the upregulation of peroxisome proliferator-activated receptor gamma (PPARG) could promote chemosensitivity of hypopharyngeal squamous cell carcinoma (HSCC) in chemotherapeutic treatments. Here, we acquired two more independent expression data of PPARG to validate the expression levels of PPARG in chemotherapy-sensitive patients (CSP) and its individualized variations compared to chemotherapy-non-sensitive patients (CNSP). Our results showed that overall PPARG expression was mildly downregulated ( log fold change = − 0.55 ; p value = 0.42; overexpression in three CSPs and reduced expression in four CSPs), which was not consistent with previous results ( log fold change = 0.50 ; p = 0.22 ; overexpression in nine CSPs and reduced expression in three CSPs). Both studies indicated that PPARG expression variation was significantly associated with the Tumor-Node-Metastasis (TNM) stage ( p = 7.45 e − 7 and 6.50 e − 4 , for the first and second studies, respectively), which was used as one of the predictors of chemosensitivity. The new dataset analysis revealed 51 genes with significant gene expression changes in CSPs ( LFC > 1 or <-1; p value < 0.01), and two of them (TMEM45A and RBP1) demonstrated strong coexpression with PPARG ( Pearson correlation coefficient > 0.6 or <-0.6). There were 21 significant genes in the data from the first study, with no significant association with PPARG and no overlap with the 51 genes revealed in this study. Our results support the connection between PPARG and chemosensitivity in HSCC tumor cells. However, significant PPARG variation exists in CSPs, which may be influenced by multiple factors, including the TNM stage.

show abstract

“…(Cardozo et al 2007;Gressler et al 2009Gressler et al , 2011Martins et al, 2016). Furthermore, isolated compounds, extracts and fractionated extracts have been reported to have important biological activities, including anti-inflammatory, neglected diseases such as leishmanicidal, trypanocidal ( Torres et al 2014;Falkenberg et al 2019;Rangel et al 2019;Clementino et al 2020;, schistosomicidal (Stein et al 2021), antioxidant and UV absorber (Rangel et al 2020;Tavares et al 2020a;2020b), anticancer (Vieira et al 2016;Santos-Pirath et al 2020, Gambato et al 2014, biofilms for drug release (Paniz et al 2020) and microbicidal properties as antifungal (Stein et al 2011), antivirus (Cirne-Santos et al 2020, antifouling ( Salgado et al 2008, Carvalho et al 2017. Due to the different uses and wide availability of these photosynthetic organisms, the interest has turned from wild harvest to farming and controlled cultivation.…”

Section: Macroalgaementioning

confidence: 99%

Bioprospecting macroalgae, marine and terrestrial invertebrates & their associated microbiota

Costa-Lotufo

¹

,

Colepicolo

²

,

Pupo

³

et al. 2022

Self Cite

View full text Add to dashboard Cite

The present review aims the discussion of the impact of the bioprospection initiative developed by the projects associated to BIOprospecTA, a subprogram of the program BIOTA, supported by FAPESP. This review brings a summary of the main results produced by the projects investigating natural products (NPs) from non-plants organisms, as examples of the success of this initiative, focusing on the progresses achieved by the projects related to NPs from macroalgae, marine invertebrates, arthropods and associated microorganisms. Macroalgae are one of the most studied groups in Brazil with the isolation of many bioactive compounds including lipids, carotenoids, phycocolloids, lectins, mycosporine-like amino acids and halogenated compounds. Marine invertebrates and associated microorganisms have been more systematically studied in the last thirty years, revealing unique compounds, with potent biological activities. The venoms of Hymenopteran insects were also extensively studied, resulting in the identification of hundreds of peptides, which were used to create a chemical library that contributed for the identification of leader models for the development of antifungal, antiparasitic, and anticancer compounds. The built knowledge of Hymenopteran venoms permitted the development of an equine hyperimmune serum anti honeybee venom. Amongst the microorganisms associated with insects the bioprospecting strategy was to understand the molecular basis of intra- and interspecies interactions (Chemical Ecology), translating this knowledge to possible biotechnological applications. The results discussed here reinforce the importance of BIOprospecTA program on the development of research with highly innovative potential in Brazil.

show abstract

Apoptotic events induced by a natural plastoquinone from the marine alga Desmarestia menziesii in lymphoid neoplasms

Cited by 4 publications

References 47 publications

Molecular Mechanism of Mature Honey Formation by GC-MS- and LC-MS-Based Metabolomics

Molecular Mechanism of Mature Honey Formation by GC-MS- and LC-MS-Based Metabolomics

Variation of PPARG Expression in Chemotherapy-Sensitive Patients of Hypopharyngeal Squamous Cell Carcinoma

Bioprospecting macroalgae, marine and terrestrial invertebrates & their associated microbiota

Contact Info

Product

Resources

About