Apoptotic endocrinal toxic effects of perchlorate in human placental cells

Ali, Musab A. M.; Khater, Sarah A.; Fayed, Amel; Sabry, Dina; Ibrahim, Samah F.

doi:10.1016/j.toxrep.2021.04.002

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Morphology and motility were determined using a light microscope (Nikon E100). Gram stain, catalase and peroxidase activity assays were performed according to the protocol described by [12]. The biochemical profile was determined with the BBL Crystal™ kit [2], [6], [24].…”

Section: Physiological Characterisation Of Bacterial Isolatesmentioning

confidence: 99%

“…In humans, the intake of contaminated food and water causes hypothyroidism [4], [12], [13], [14] generating an increase in cardiovascular diseases; neurological, reproductive and immunological [15] Metabolism, development, and reproduction in humans can be affected by high concentrations of (ClO -); due to the decreased transfer of thyroid hormones from the placenta to the fetus [12]. In men, the deterioration in the genetic material results in the reduction of testicular spermatogenesis [12]. In newborns and children, it can cause deterioration of the skeletal system and the central nervous system [4], [13], [16].…”

Section: Introductionmentioning

confidence: 99%

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Psychrobacter sp: perchlorate reducing bacteria, isolated from marine sediments from Margarita Bay, Antarctica.

Acevedo Barrios,

Hernández Rocha,

Puentes Martinez

et al. 2023

Proceedings of the 21th LACCEI International Multi-Conference for Engineering, Education and Technology (LACCEI 2023): “Leaders

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Perchlorate (ClO -) is an ion that occurs naturally in Antarctica, it is considered an emerging pollutant because it is a powerful endocrine disruptor that affects the functioning of the thyroid gland and the growth and development of humans and biota. The objective of this study was to characterize salt-tolerant bacteria that reduce (ClO -) from marine sediments of Bahía Margarita, Antarctica, collected in the V Colombian Scientific Expedition to Antarctica "Almirante Tono" in 2019. The methodology used included three stages: [1] Isolation of the bacteria: for which broth and LB agar modified with seawater were used [2] Morphological and biochemical characterization of the isolated strains: through Gram staining, tests for catalase, oxidase and BBL Crystal; [3] Susceptibility tests (NaCl and ClO -) and ClO4-reduction test using selective electrode. The bacterial isolates grew at 10 °C for 7 days, tolerated NaCl concentrations up to 20% v/v and (ClO -)concentrations up to 10,000 mg/L; with pH variations between 6.5 to 12.0. This contaminant was reduced by the isolated strains in percentages between 18% and 41%. The morphological and biochemical characterization of the isolated strains indicated that they were related to the genus Psychrobacter. In conclusion, salttolerant bacteria isolated from marine sediments in Margarita Bay, Antarctica are promising resources for bioremediation of (ClO -) pollution in ecosystems. Keywords-extreme environments, halotolerant bacteria, marine sediments, polar environments, toxicity.

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