Apoptotic effects of valproic acid on miR-34a, miR-520h and HDAC1 gene in breast cancer

Injinari, Nastaran; Amini‐Farsani, Zeinab; Yadollahi-Farsani, Mahtab; Teimori, Hossein

doi:10.1016/j.lfs.2021.119027

Cited by 18 publications

(13 citation statements)

References 43 publications

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“…The function of miRNAs is essential for the development of different physiological systems and the maintenance of their cell homeostasis and normal functioning. Numerous miRNA variants play roles in various biological processes such as cell signaling regulation, differentiation, cell cycle, growth, apoptosis, tumorigenesis, and neurogenesis [7] ; Amini-Farsani & Asgharzade, 2020; [9] , [34] , [49] . MiRNAs comprise about 1-5% of the animal genomes, and it is estimated that there are approximately 800-1000 miRNAs in the human genome and that over one-third of the protein-coding genome is regulated by miRNAs.…”

Section: Mirna Biogenesismentioning

confidence: 99%

Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathways

Amini‐Farsani

Yadollahi-Farsani

Arab

et al. 2021

International Immunopharmacology

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COVID-19 is the cause of a pandemic associated with substantial morbidity and mortality. As yet, there is no available approved drug to eradicate the virus. In this review article, we present an alternative study area that may contribute to the development of therapeutic targets for COVID-19. Growing evidence is revealing further pathophysiological mechanisms of COVID-19 related to the disregulation of inflammation pathways that seem to play a critical role toward COVID-19 complications. The NF-kB and JAK/STAT signaling pathways are highly activated in acute inflammation, and the excessive activity of these pathways in COVID-19 patients likely exacerbates the inflammatory responses of the host. A group of non-coding RNAs (miRNAs) manage certain features of the inflammatory process. In this study, we discuss recent advances in our understanding of miRNAs and their connection to inflammatory responses. Additionally, we consider the link between perturbations in miRNA levels and the onset of COVID-19 disease. Furthermore, previous studies published in the online databases, namely web of science, MEDLINE (PubMed), and Scopus, were reviewed for the potential role of miRNAs in the inflammatory manifestations of COVID-19. Moreover, we disclosed the interactions of inflammatory genes using STRING DB and designed interactions between miRNAs and target genes using Cityscape software. Several miRNAs, particularly miR-9, miR-98, miR-223, and miR-214, play crucial roles in the regulation of NF-kB and JAK-STAT signaling pathways as inflammatory regulators. Therefore, this group of miRNAs that mitigate inflammatory pathways can be further regarded as potential targets for far-reaching-therapeutic strategies in COVID-19 diseases.

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Section: Mirna Biogenesismentioning

confidence: 99%

Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathways

Amini‐Farsani

Yadollahi-Farsani

Arab

et al. 2021

International Immunopharmacology

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“…HDAC1 and HDAC4 belong to class I of HDAC. Previous studies have shown that HDAC1 is overexpressed in a variety of human malignancies, such as prostate cancer, breast cancer, liver cancer and lung cancer [ 26 – 28 ]. HDAC1 is also highly expressed in glioma tissues, and high expression of glioma is related to the proliferation, migration, invasion, angiogenesis, and poor prognosis of glioma cells [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analyses reveal the role of histone deacetylase genes in prognosis and immune response in low-grade glioma

Shen

et al. 2022

PLoS ONE

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Many studies have shown that Histone deacetylases (HDAC) is involved in the occurrence of malignant tumors and regulates the occurrence, proliferation, invasion, and migration of malignant tumors through a variety of signaling pathways. In the present, we explored the role of Histone deacetylases genes in prognosis and immune response in low-grade glioma. Using consensus clustering, we built the new molecular clusters. Using HDAC genes, we constructed and validated the prognostic model in two independent cohort datasets. Patients were divided into high-risk and low-risk groups. Then, we explored the molecular characteristics, clinical characteristics, tumor microenvironment and immune infiltration levels of two clusters and risk groups. Receiver operating characteristic analyses were built for model assessment. We finally detected the expression levels of signature genes between tumor and normal tissues. Low-grade can be separated into two molecular clusters using 11 HDACs genes. Two clusters had different clinical characteristics and prognosis. Nex, we constructed a prognosis model using six HDAC genes (HDAC1, HDAC4, HDAC5, HDAC7, HDAC9, and HDAC10), which was also validated in an independent cohort dataset. Furthermore, multivariate cox regression indicated that the calculated risk score was independently associated with prognosis in low-grade glioma, and risk score can predict the five-year survival probability of low-grade glioma well. High-risk patients can be attributed to multiple complex function and molecular signaling pathways, and the genes alterations of high- and low-risk patients were significantly different. We also found that different survival outcomes of high- and low- risk patients could be involved in the differences of immune filtration level and tumor microenvironment. Subsequently, using signature genes, we identified several small molecular compounds that could be useful for low-grade glioma patients’ treatment. Finally, we detected the expression levels of signature genes in tumor tissues. our study uncovers the biology function role of HDAC genes in low-grade glioma. We identified new molecular subtypes and established a prognostic model based on six HDAC genes, which was well applied in two independent cohort data. The regulation of HDAC genes in low-grade glioma involved in multiple molecular function and signaling pathways and immune infiltration levels. Further experiments in vivo and vitro were required to confirm the present findings.

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“…VPA has been approved by the FDA for the treatment of epilepsy and other convulsive diseases and has been used successfully in the therapy of these diseases for over five decades [ 52 ]. It has been demonstrated that VPA shows anticancer activity ( Figure 4 ) in a diversity of human cancers [ 53 , 54 , 55 ], including breast carcinoma [ 56 , 57 , 58 , 59 ].…”

Section: Valproic Acid and Breast Cancermentioning

confidence: 99%

“…Similarly like in MDA-MB-231 BC cells, in cancer tissue the expression of miR-34a and miR-520h significantly decreased, while the expression of HDAC1 increased after VPA treatment in vivo. This raises the possibility that VPA differently regulates the expression of the same genes, depending on BC cancer type or their molecular profiling ( Table 3 ) [ 56 ].…”

Section: Valproic Acid and Breast Cancermentioning

confidence: 99%

Valproic Acid and Breast Cancer: State of the Art in 2021

Wawruszak

Hałasa

Okon

et al. 2021

Cancers

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Valproic acid (2-propylpentanoic acid, VPA) is a short-chain fatty acid, a member of the group of histone deacetylase inhibitors (HDIs). VPA has been successfully used in the treatment of epilepsy, bipolar disorders, and schizophrenia for over 50 years. Numerous in vitro and in vivo pre-clinical studies suggest that this well-known anticonvulsant drug significantly inhibits cancer cell proliferation by modulating multiple signaling pathways. Breast cancer (BC) is the most common malignancy affecting women worldwide. Despite significant progress in the treatment of BC, serious adverse effects, high toxicity to normal cells, and the occurrence of multi-drug resistance (MDR) still limit the effective therapy of BC patients. Thus, new agents which improve the effectiveness of currently used methods, decrease the emergence of MDR, and increase disease-free survival are highly needed. This review focuses on in vitro and in vivo experimental data on VPA, applied individually or in combination with other anti-cancer agents, in the treatment of different histological subtypes of BC.

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Apoptotic effects of valproic acid on miR-34a, miR-520h and HDAC1 gene in breast cancer

Cited by 18 publications

References 43 publications

Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathways

Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathways

Comprehensive analyses reveal the role of histone deacetylase genes in prognosis and immune response in low-grade glioma

Valproic Acid and Breast Cancer: State of the Art in 2021

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