Apoptotic effect of β-pinene on oral squamous cell carcinoma as one of the major compounds from essential oil of medicinal plant <i>Piper rivinoides</i> Kunth

Machado, Thaíssa Queiróz; Felisberto, Jéssica Regina Sales; Guimarães, Elsie Franklin; Queiroz, George Azevedo de; Fonseca, Anna Carolina Carvalho da; Ramos, Ygor Jessé; Marques, André M.; Moreira, Davyson de Lima; Robbs, Bruno Kaufmann

doi:10.1080/14786419.2021.1895148

Cited by 21 publications

(20 citation statements)

References 11 publications

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“…It was observed in human oral tongue cancer cells that (-)- β -pinene showed cytotoxicity, altered cell morphology, large amounts of pyknotic nuclei, membrane blebs, and cell shrinkage, and caspase inhibitors ZVAD (pancaspase) and ZDEVD (caspase-3) reduced cell death. In addition, (-)- β -pinene also showed selectivity in primary normal human gingival fibroblast [ 16 ]. β -Pinene has also been evaluated in association with an already established drug, paclitaxel, in non-small-cell lung cancer cells.…”

Section: Resultsmentioning

confidence: 99%

“…Arg., a native plant from Northeast Brazil used in folk medicine, has ascaridole, a monoterpene, as one of the main constituents with high antitumor activity against leukemia, glioblastoma, and sarcomas in mice models [ 15 ]. Furthermore, monoterpenes (-)- α -pinene, (-)- β -pinene, and limonene from essential oils from Piper rivinoides Kunth were active against tumor cell lines of oral squamous cell carcinoma (SCC9 and SCC25), showing greater selectivity in relation to carboplatin, the drug of choice in the clinic [ 16 ]. Thus, as described in Method, the present study performed an up-to-date review of essential oil monoterpenes with antitumor activity.…”

Section: Introductionmentioning

confidence: 99%

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A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update

Machado

Fonseca

Duarte

et al. 2022

BioMed Research International

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Monoterpenes are a group of natural products that have been widely studied due to their therapeutic potential against various pathologies. These compounds are abundant in the chemical composition of essential oils. Cancer is a term that covers more than 100 different types of malignant diseases and is among the leading causes of death in the world. Therefore, the search for new pharmacotherapeutic options applicable to cancer is urgent. In this review, studies on the antitumor activity of monoterpenes found in essential oils were selected, and botanical, chemical, and pharmacological aspects were discussed. The most investigated monoterpenes were carvacrol and linalool with highly significant in vitro and in vivo tumor inhibition in several types of cancers. The action mechanisms of these natural products are also presented and are wildly varied being apoptosis the most prevalent followed by cell cycle impairment, ROS production, autophagy, necroptosis, and others. The studies reported here confirm the antitumor properties of monoterpenes and their anticancer potential against various types of tumors, as demonstrated in in vitro and in vivo studies using various types of cancer cells and tumors in animal models. The data described serve as a reference for the advancement in the mechanistic studies of these compounds and in the preparation of synthetic derivatives or analogues with a better antitumor profile.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update

Machado

Fonseca

Duarte

et al. 2022

BioMed Research International

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“…In a similar study, Thymus caramanicus essential oil has shown anti-proliferative and cytotoxic properties on KB cells [ 38 ]. Another recent study has shown that essential oil from P. rivinoides exhibits cytotoxic activity in oral squamous cell carcinoma cell lines [ 39 ]. Additionally, it has been shown that herbal ingredients not only act as chemopreventive and chemotherapeutic agents but also have beneficial effects on chemotherapy-induced side effects.…”

Section: Herbal Remedies For Dental Diseasesmentioning

confidence: 99%

Exploring the Potential of Natural Product-Based Nanomedicine for Maintaining Oral Health

et al. 2022

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Oral diseases pose a major threat to public health across the globe. Diseases such as dental caries, periodontitis, gingivitis, halitosis, and oral cancer affect people of all age groups. Moreover, unhealthy diet practices and the presence of comorbidities aggravate the problem even further. Traditional practices such as the use of miswak for oral hygiene and cloves for toothache have been used for a long time. The present review exhaustively explains the potential of natural products obtained from different sources for the prevention and treatment of dental diseases. Additionally, natural medicine has shown activity in preventing bacterial biofilm resistance and can be one of the major forerunners in the treatment of oral infections. However, in spite of the enormous potential, it is a less explored area due to many setbacks, such as unfavorable physicochemical and pharmacokinetic properties. Nanotechnology has led to many advances in the dental industry, with various applications ranging from maintenance to restoration. However, can nanotechnology help in enhancing the safety and efficacy of natural products? The present review discusses these issues in detail.

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“…Literature data on EO, obtained by hydrodistillation from fresh leaves of P. rivinoides, have shown a great chemical diversity rich in monoterpenes, sesquiterpenes, and arylpropanoids, which may vary depending on the collection site (Bernuci et al, 2016;Perigo et al, 2016;Leal et al, 2019). Aspects of the pharmacological potential of these EO indicate their antinociceptive (Souza et al, 2014), antifungal (Bernuci et al, 2016;Leal et al, 2019), antimicrobial (Leal et al, 2019), and cytotoxic (Fonseca et al, 2020;Machado et al, 2021) activity.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the apoptotic effect of β-pinene (main component) and EO of P. rivinoides in oral squamous cell carcinoma (Machado et al, 2021) was described. This study confirmed the plant's long history of traditional medicinal use in the treatment of oral problems (Barros, 2010).…”

Section: Introductionmentioning

confidence: 99%

Piper rivinoides Kunth: A medicinal plant that preserves bioactive chemical substances in its essential oil throughout the seasons

Jéssica¹,

Ygor²,

George³

et al. 2022

J. Med. Plants Res.

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The chemical composition and seasonal variation of essential oils (EO) extracted from the aerial parts of the traditional medicinal plant Piper rivinoides were analyzed using gas chromatography (GC) coupled with mass spectrometry (MS) and GC coupled with flame ionization detector (GC-FID) technique, respectively. The wild plants were collected from two different sites in the Atlantic Forest. The analysis allowed us to identify 96.60 to 99.80% of the EO composition. The major compounds with the highest relative percentage for both specimens, regardless of the season, were the bioactive monoterpenes α-pinene and β-pinene, which ranged from 34.78 (summer) to 53.87% (winter) and from 15.24% (autumn) to 47.71% (winter), respectively. The seasonal stability of the major compounds in the two study specimens throughout the year indicates that the phenological cycle influences biosynthesis more than abiotic factors. This type of chemical phenotypic stability is rarely observed in species belonging to the Piperaceae family, which is characterized by high chemical variability. Furthermore, this stability is favorable, and P. rivinoides has the potential to be a source of bioactive compounds.

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Apoptotic effect of β-pinene on oral squamous cell carcinoma as one of the major compounds from essential oil of medicinal plant Piper rivinoides Kunth

Cited by 21 publications

References 11 publications

A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update

A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update

Exploring the Potential of Natural Product-Based Nanomedicine for Maintaining Oral Health

Piper rivinoides Kunth: A medicinal plant that preserves bioactive chemical substances in its essential oil throughout the seasons

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