Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells

Wu, Cong; Zhang, Yi; Jiang, Yingming; Wang, Quanxing; Long, Yao; Wang, Chunmei; Cao, Xuetao; Chen, Guoyou

doi:10.1038/cmi.2013.16

Cited by 28 publications

(37 citation statements)

References 52 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypoxia and cell death in the tumor microenvironment may contribute to the induction of tumor immunosuppression. 15 Furthermore, many new immunosuppressive cell subsets have been identified in cancer patients. 16 Thus, the cellular and molecular mechanism for the generation of TAMs may be more complicated than we expected.…”

Section: Ccr2mentioning

confidence: 99%

The origin and function of tumor-associated macrophages

2014

Self Cite

View full text Add to dashboard Cite

Section: Ccr2mentioning

confidence: 99%

The origin and function of tumor-associated macrophages

2014

Self Cite

View full text Add to dashboard Cite

“…Production of inflammatory and tolerogenic DCs can be induced in several ways. For example, tolerogenic DCs can be induced by anti-inflammatory cytokines such as IL-10 and TGF-β and by some biological molecules such as vitamin D 3 and apoptotic cells [15-17]. Our project is focused on tolerogenic DCs induced by apoptotic T cells [18].…”

Section: Introductionmentioning

confidence: 99%

Apoptotic cell-treated dendritic cells induce immune tolerance by specifically inhibiting development of CD4+ effector memory T cells

2015

View full text Add to dashboard Cite

CD4+ memory T cells play an important role in induction of autoimmunity and chronic inflammatory responses; however, regulatory mechanisms of CD4+ memory T cell-mediated inflammatory responses are poorly understood. Here we show that apoptotic cell-treated dendritic cells inhibit development and differentiation of CD4+ effector memory T cells in vitro and in vivo. Simultaneously, i.v. transfer of apoptotic T cell-induced tolerogenic dendritic cells can block development of experimental autoimmune encephalomyelitis (EAE), an inflammatory disease of the central nervous system in C57 BL/6J mouse. Our results imply that it is effector memory CD4+ T cells, not central memory CD4+ T cells, which play a major role in chronic inflammatory responses in mice with EAE. I.V. transfer of tolerogenic dendritic cells induced by apoptotic T cells leads to immune tolerance by specifically blocking development of CD4+ effector memory T cells compared with results of EAE control mice. These results reveal a new mechanism of apoptotic cell-treated dendritic cell-mediated immune tolerance in vivo

show abstract

“…64 In the immune tolerance model induced by apoptotic cell administration, tol-DCs promoted the expansion of Tregs via PD-L1 expression on their surface, and Tregs facilitated maintenance of a tolerogenic state by tol-DCs via IL-10 and TGF-b. 65 66 These findings highlight that reciprocal interactions between tol-DCs and Tregs are essential for the induction and maintenance of immune tolerance.…”

Section: Interactions Between Tol-dcs and Other Immune Cells Tol-dcs mentioning

confidence: 86%

Tolerogenic dendritic cells and their applications in transplantation

Shi

2014

Cell Mol Immunol

View full text Add to dashboard Cite

In transplantation immunology, the ultimate goal is always to successfully and specifically induce immune tolerance of allografts. Tolerogenic dendritic cells (tol-DCs) with immunoregulatory functions have attracted much attention as they play important roles in inducing and maintaining immune tolerance. Here, we focused on tol-DCs that have the potential to promote immune tolerance after solid-organ transplantation. We focus on their development and interactions with other regulatory cells, and we also explore various tol-DC engineering protocols. Harnessing tol-DCs represents a promising cellular therapy for promoting long-term graft functional survival in transplant recipients that will most likely be achieved in the future.

show abstract

Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells

Cited by 28 publications

References 52 publications

The origin and function of tumor-associated macrophages

The origin and function of tumor-associated macrophages

Apoptotic cell-treated dendritic cells induce immune tolerance by specifically inhibiting development of CD4+ effector memory T cells

Tolerogenic dendritic cells and their applications in transplantation

Contact Info

Product

Resources

About