Apoptotic Bodies of Cardiomyocytes and Fibroblasts — Regulators of Directed Differentiation of Heart Stem Cells

Tyukavin, A. I.; Belostotskaya, G. B.; Zakharov, E.A.; Ivkin, D. Yu.; Rad'ko, S V; Knyazev, Nickolay A.; Клименко, В. В.; Богданов, А. А.; Suchkov, Sergey

doi:10.1007/s10517-020-05015-0

Cited by 8 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of CSC-derived colonies, CICSs and TACs in myocardium proved the previous hypothesis about two pathways that generate new CMs in adult heart. Moreover, we suggest that TACs play a central role in self-renewal of myocardium throughout the lifetime of mammals [40].…”

Section: Management Of Regenerative Cardiomyogenesismentioning

confidence: 85%

“…When ApB enters the CSC via endocytosis, a specific set of long and short noncoding RNAs express genes that determine the direction of differentiation of resident myocardial stem cells. It can be assumed that this hypothesis is true not only for the heart, but also for other organs and tissues [38,39]. CMs, representing the major mechanism of myocardial regeneration.…”

Section: Management Of Regenerative Cardiomyogenesismentioning

confidence: 99%

See 1 more Smart Citation

The Challenges of the Design-Driven Biotech Resources and Unique Translational Tools to Manage Cardiac Self-Renewal and Regeneration to be utilized in Clinical Practice

Suchkov

2024

OAJFS

View full text Add to dashboard Cite

The approaches securing cardiac regeneration in post-infarction period are not available to be practiced. The key problem is the identity of cells is born to generate functionally active cardiac myocytes replenishing those being lost during ischemia. Over the last years, stem cells (SCs) have been a promise for the cure of several diseases, including heart failures, not only due to their plasticity but also acting as paracrine modulators and influencing the affected tissue. Human SC-based therapy derivatives are extremely attractive for therapeutic development because they have direct pharmacologic utility in clinical applications, unlike any other adult cells. Moreover, SC derived paracrine factors are to suppress inflammation and apoptosis, whilst stimulating angiogenesis, and amplifying the proliferation and differentiation of resident cardiac SCs (CSCs). SC therapies are thus viable alternatives to canonical treatments with substantial therapeutic potential; market opportunities are huge as multiple product candidates are expected to be approved over the coming decade. In this review, we accumulated recent data in the field of cardiac regeneration after MI using the latest resources of personalized and precision medicine (PPM), and considered promising ways of targeting pharmacotherapy and regenerative medicine in the field of cardiac rehabilitation.

show abstract

Section: Management Of Regenerative Cardiomyogenesismentioning

confidence: 85%

Section: Management Of Regenerative Cardiomyogenesismentioning

confidence: 99%

The Challenges of the Design-Driven Biotech Resources and Unique Translational Tools to Manage Cardiac Self-Renewal and Regeneration to be utilized in Clinical Practice

Suchkov

2024

OAJFS

View full text Add to dashboard Cite

show abstract

“…When ApB enters the CSC via endocytosis, a specific set of long and short non-coding RNAs express genes that determine the direction of differentiation of resident myocardial stem cells. It can be assumed that this hypothesis is true not only for the heart, but also for other organs and tissues [20].…”

Section: Pluripotentmentioning

confidence: 99%

Stem Cell Technologies to Integrate Bio Design- Related Tissue Engineering within the Frame of Cell- Based Regenerative Medicine: Towards the Preventive, Therapeutic and Rehabilitative Resources and Benefits

Suchkov

2024

AJBSR

View full text Add to dashboard Cite

“…In addition, ApoBDs of cardiomyocytes and fibroblasts stimulate stem cells in the heart. ApoBDs of cardiomyocytes promote clones of cardiomyocyte precursors in the myocardium, while ApoBDs of fibroblasts stimulate the formation of endothelial precursor clones [ 174 ]. Liu et al found that MSCs-derived ApoBDs enhance lysosome biosynthesis and regulate autophagy and angiogenesis in recipient endothelial cells by activating transcription factor EB.…”

Section: Applications Based On Non-engineered and Engineered Apobdsmentioning

confidence: 99%

Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials

Zhu

Zhang

et al. 2023

J Nanobiotechnol

View full text Add to dashboard Cite

Apoptosis, a form of programmed cell death, is essential for growth and tissue homeostasis. Apoptotic bodies (ApoBDs) are a form of extracellular vesicles (EVs) released by dying cells in the last stage of apoptosis and were previously regarded as debris of dead cells. Recent studies unraveled that ApoBDs are not cell debris but the bioactive treasure left behind by the dying cells with an important role in intercellular communications related to human health and various diseases. Defective clearance of ApoBDs and infected-cells-derived ApoBDs are possible etiology of some diseases. Therefore, it is necessary to explore the function and mechanism of the action of ApoBDs in different physiological and pathological conditions. Recent advances in ApoBDs have elucidated the immunomodulatory, virus removal, vascular protection, tissue regenerative, and disease diagnostic potential of ApoBDs. Moreover, ApoBDs can be used as drug carriers enhancing drug stability, cellular uptake, and targeted therapy efficacy. These reports from the literature indicate that ApoBDs hold promising potential for diagnosis, prognosis, and treatment of various diseases, including cancer, systemic inflammatory diseases, cardiovascular diseases, and tissue regeneration. This review summarizes the recent advances in ApoBDs-related research and discusses the role of ApoBDs in health and diseases as well as the challenges and prospects of ApoBDs-based diagnostic and therapeutic applications. Graphical Abstract

show abstract

Apoptotic Bodies of Cardiomyocytes and Fibroblasts — Regulators of Directed Differentiation of Heart Stem Cells

Cited by 8 publications

References 29 publications

The Challenges of the Design-Driven Biotech Resources and Unique Translational Tools to Manage Cardiac Self-Renewal and Regeneration to be utilized in Clinical Practice

The Challenges of the Design-Driven Biotech Resources and Unique Translational Tools to Manage Cardiac Self-Renewal and Regeneration to be utilized in Clinical Practice

Stem Cell Technologies to Integrate Bio Design- Related Tissue Engineering within the Frame of Cell- Based Regenerative Medicine: Towards the Preventive, Therapeutic and Rehabilitative Resources and Benefits

Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials

Contact Info

Product

Resources

About