Apoptosis Triggering in Breast Cancer Cells with Co-delivery of Melatonin and Doxorubicin Loaded into Human Adipose Mesenchymal Stem Cell Derived Exosomes
Moein Shirzad,
Abdolreza Daraei,
Hossein Najafzadehvarzi
et al.
Abstract:Background
In recent years, numerous efforts have been dedicated to reducing the side effects of doxorubicin (DOX). Exosomes (EXOs), as extracellular vesicles (EVs), can play a role in the safe transport of DOX in breast cancer treatment. The aim of this study was to alleviate the adverse effects associated with DOX while enhancing its targeted delivery to cancer cells through the codelivery of melatonin (MEL) as an antioxidant and DOX into EXOs-derived from human adipose tissue mesenchymal stem cells (A-MSCs… Show more
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