Apoptosis-related proteins and cervical intraepithelial neoplasia in human immunodeficiency virus-seropositive women

Spinillo, Arsenio; Zara, Francesca; Zappatore, Rita; Cesari, Stefania; Bergante, Carola; Morbini, Patrizia

doi:10.1016/j.ygyno.2004.09.006

“…Similarly, Cheah and Looi (2006) observed that Bcl-2 was upregulated in HSIL and Bax was downregulated in squamous cell carcinoma (SCC) when compared with benign cervical squamous epithelium. In the same way, Spinillo et al (2004) showed an increase of Bcl-2 expression correlated with the severity of CIN. Fonseca-Moutinho et al (2004) observed that estrogen receptor (ER) and progesterone receptor (PR), Bcl-2, and Bax immunohistochemical expression was stronger and more frequent in the CIN III group.…”

Section: Discussionmentioning

confidence: 57%

Balance of apoptotic and anti-apoptotic marker and perforin granule release in squamous intraepithelial lesions. HIV infection leads to a decrease in perforin degranulation

Fernandes

¹

,

Rocha

²

,

Avvad

³

et al. 2013

Experimental and Molecular Pathology

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…A possível ação genotóxica do HPV e a incapacidade em depurar de maneira satisfatória o vírus podem ser caracterizadas clinicamente pela maior prevalência de alguns tipos específicos de tumores na população com comprometimento imunitário [5][6][7] . Estudos propõem que a lesão do genoma de indivíduos soropositivos para o vírus da imunodeficiência humana adquirida (HIV) poderia estar associada ao gene Vpr, um gene acessório do HIV-1 e HIV-2, com capacidade de induzir anormalidades no ciclo celular durante o período G2, promovendo, assim, instabilidade genômica [8][9][10] . Nicol et al 4 demonstraram de maneira elegante que existem alterações significantes na expressão de fatores associados ao desenvolvimento neoplásico em mulheres HIV+, tais como o fator de crescimento endotelial vascular e proteínas inibidoras da CPK, ambos associados na regulação e no ciclo celular.…”

Section: Introductionunclassified

“…A contagem de células CD4+ é usada clinicamente como marcador geral de competência do sistema imune, e sua depleção indica deficiência grave na imunidade celular 8 . Baixa carga viral para HIV, por sua vez, é considerada bom marcador preditivo do prognóstico da doença viral e/ ou de sobrevida 13 .…”

Section: Introductionunclassified

Micronúcleos em células do colo uterino em mulheres HIV+ segundo sua condição de imunidade

Mendes

¹

,

Filho

²

,

Furoni

³

et al. 2011

Rev. Bras. Ginecol. Obstet.

6

0

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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Characterization of cervical biopsies of women with HIV and HPV co-infection using p16ink4a, ki-67 and HPV E4 immunohistochemistry and DNA methylation

Kremer

¹

,

Vink

²

,

Zummeren

³

et al. 2020

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

Apoptosis-related proteins and cervical intraepithelial neoplasia in human immunodeficiency virus-seropositive women

Cited by 3 publications

References 18 publications

Balance of apoptotic and anti-apoptotic marker and perforin granule release in squamous intraepithelial lesions. HIV infection leads to a decrease in perforin degranulation

Balance of apoptotic and anti-apoptotic marker and perforin granule release in squamous intraepithelial lesions. HIV infection leads to a decrease in perforin degranulation

Micronúcleos em células do colo uterino em mulheres HIV+ segundo sua condição de imunidade

Characterization of cervical biopsies of women with HIV and HPV co-infection using p16ink4a, ki-67 and HPV E4 immunohistochemistry and DNA methylation

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