Apoptosis of neutrophils resulting after emperipolesis in cutaneous Rosai-Dorfman disease: a new ultrastructural finding

Kusutani, Nao; Tamiya, Hisashi; Tsuruta, D.; Mizuno, Nobuyuki; Sowa, Junko; Kaida, M.; Ishii, Masamitsu; Yamamoto, Osamu; Kobayashi, Hiromi

doi:10.1111/j.1600-0560.2011.01678.x

Cited by 9 publications

(4 citation statements)

References 10 publications

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“…The histiocytes contain large vesicular nuclei, small nucleoli, and pale cytoplasm [ 15 16 17 ]. Emperipolesis is the pathognomonic finding, which is the result of histiocytes engulfing intact lymphocytes surrounded by a clear halo [ 18 ]. Histiocytes show diffuse cytoplasmic and nuclear staining for S100 and CD68 but do not stain with CD1a.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Rosai-Dorfman Disease Confused with Vascular Mass

Kang

Jung

Koh

2016

Arch Craniofac Surg

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Rosai-Dorfman disease is a rare histiocytic disorder, clinically characterized by massive, bilateral painless cervical lymphadenopathy with potential for extranodal manifestations. We report a 45-year-old male patient who presented with a slowly growing erythematous nodule of the left chin. The mass appeared non-vascular on computed tomography study, but ultrasonogram was suggestive of a vascular lesion. The lesion was excised with presumptive diagnosis of a hemangioma. However, histopathologic examination of the surgical biopsy revealed histiocytic infiltration with emperipolesis, which was pathognomic for Rosai-Dorfman disease. Additional imaging studies did not reveal lymph node enlargement or other extranodal manifestation. The patient was diagnosed with cutaneous form of the Rosai-Dorfman disease and was discharged home. He remains free of local recurrence at 8 months.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Rosai-Dorfman Disease Confused with Vascular Mass

Kang

Jung

Koh

2016

Arch Craniofac Surg

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“…The main diagnostic criterion is the finding of intact lymphocytes inside the macrophage, a process called lymphophagocytosis or emperipolesis. RDD is diagnostically qualified by positive S-100 (Figure 4), and this stain is considered the most useful for disease recognition (7). The usual presentation of some large cells demonstrating emperipolesis of lymphocytes was not observed in the present tissue sample ( Figure 5).…”

Section: Discussionmentioning

confidence: 83%

Rare Presentation of Rosai-Dorfman Disease Mimicking a Cervical Intramedullary Spinal Cord Tumor

Molla

Mahasneh

Holmes³

et al. 2014

World Neurosurgery

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“…Some or all of the characteristic findings of foamy histiocytes, multinucleated giant cells, and eosinophils can be seen in other systemic histiocytic disorders, including but not limited to Langerhans cell histiocytosis (LCH), Rosai‐Dorfman disease (RDD) sarcoidosis (Table ) . In this context, Langerhans cells possess a distinctive cytomorphology entailing longitudinal grooving, and can be shown to contain tennis racket‐shaped Birbeck granules on ultrastructural examination .…”

Section: Discussionmentioning

confidence: 99%

“…Coexistent ECD and LCH have been documented and should be suspected in patients with atypical presentation of either disorder . Another similar lesion is RDD . Primarily a histopathologic diagnosis, RDD is characterized by the presence of a large number of histiocytes, many of which contain engulfed inflammatory cells (emperipolesis), and admixed lymphocytes, neutrophils and plasma cells in various proportions .…”

Section: Discussionmentioning

confidence: 99%

Erdheim‐Chester disease with prominent pericardial effusion

Alexiev

Staats

2013

Diagnostic Cytopathology

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Erdheim-Chester disease (ECD) is a rare, non-Langerhans form of histiocytosis of unknown origin with distinct clinicopathologic and radiographic features. Reports detailing the cytology of ECD are rare. We describe a case of ECD with pericardial effusion. Cytologic examination revealed a hypercellular specimen composed of clusters and singly dispersed foamy macrophages with round nuclei and inconspicuous nucleoli, admixed with lymphocytes, eosinophils, and Touton-type multinucleated giant cells. Immunostains for CD68 were strongly positive in the foamy macrophages while S100 and CD1a were negative. The presence of foamy histiocytes, multinucleated giant cells, lymphocytes and eosinophils are also features of other systemic histiocytic disorders, including Langerhans cell histiocytosis (LCH), Rosai-Dorfman disease (RDD) and sarcoidosis. To the best of out knowledge, this is the first report describing the cytological features of ECD in a pericardial effusion.

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Apoptosis of neutrophils resulting after emperipolesis in cutaneous Rosai-Dorfman disease: a new ultrastructural finding

Cited by 9 publications

References 10 publications

Cutaneous Rosai-Dorfman Disease Confused with Vascular Mass

Cutaneous Rosai-Dorfman Disease Confused with Vascular Mass

Rare Presentation of Rosai-Dorfman Disease Mimicking a Cervical Intramedullary Spinal Cord Tumor

Erdheim‐Chester disease with prominent pericardial effusion

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