Apoptosis of Breast Cancer Cells: Modulation of Genes for Glycoconjugate Biosynthesis and Targeted Drug Delivery

Basu, Subhash; Ma, Rui; Moskal, Joseph R.; Basu, Manju; Banerjee, Sipra

doi:10.1007/978-1-4614-3381-1_16

Cited by 5 publications

(1 citation statement)

References 114 publications

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“…This program cell death starts with changes in cell nuclear morphology (chromatin condensation and fragmentation), cell shrinking, plasma membrane blebbing, and apoptotic body formation. Cancer cells are known to express abnormally elevated levels of cytoprotective and antiapoptotic enzymes, which assist them to endure cellular stress and abrogate apoptosis, resulting in enhanced survival (Basu et al, 2012). Targeting cell apoptosis is, therefore, one of the promising approaches for cancer chemotherapeutic.…”

Section: Discussionmentioning

confidence: 99%

Apoptotic and Anti-metastatic Effects of Atractylodes lancea (Thunb.) DC. in a Hamster Model of Cholangiocarcinoma

Sonsomnuek

Tarasuk

Plengsuriyakarn

et al. 2022

Asian Pac J Cancer Prev

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Section: Discussionmentioning

confidence: 99%

Apoptotic and Anti-metastatic Effects of Atractylodes lancea (Thunb.) DC. in a Hamster Model of Cholangiocarcinoma

Sonsomnuek

Tarasuk

Plengsuriyakarn

et al. 2022

Asian Pac J Cancer Prev

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Protocols for Glycosyltransferase Assays: Ganglioside Globoside and Lewis-X Intermediate-Lactosylceramide Biosyntheses in Eukaryotic Systems

et al. 2018

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Protocols for assay of 24 different Glycolipid-Glycosyltransferases (GSL-GLTs) of the eukaryotic systems are described. Problems of quantitating the activities in crude membranes are also described. Different separation methods (for separation of substrate, donors, and the product of the reaction) have been described based on the paper chromatography or high voltage paper electrophoresis in 1.0% NaBO. Liquid Scintillation counting system was used for quantitation of the enzymatic product. In the assay of each GSL-GLT it is recommended to compare the selected method to be used with the exact conditions used by the authors published previously. As a test case for these assays the following kinetic parameters for Lactosylceramide Synthase, GalT-2 (UDP-Gal: Glc-Cer β1-4-galactosyltransferase), (Km of glucosylceramide = 1.65 × 10 M; Km for UDP-Gal = 0.5 × 10 M; V is determined in the presence of optimum detergent concentrations (2-15 mg/ml of Cutscum-Triton X-100, 2:1); Mn and Mg, 10-20 mM) has been reported. The importance of use of GalT-2 assay method (as a model system) in the purified Golgi-rich membranes from 13-day-old embryonic chicken brains (13-ECB) is described.

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Regulations of Glycolipid: XI. Glycosyltransferase (GSL: GLTs) Genes Involved in SA-LeX and Related GSLs Biosynthesis in Carcinoma Cells by Biosimilar Apoptotic Agents: Potential Anticancer Drugs

Basu

Moskal³

et al. 2014

Advances in Experimental Medicine and Biology

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Apoptosis of Breast Cancer Cells: Modulation of Genes for Glycoconjugate Biosynthesis and Targeted Drug Delivery

Cited by 5 publications

References 114 publications

Apoptotic and Anti-metastatic Effects of Atractylodes lancea (Thunb.) DC. in a Hamster Model of Cholangiocarcinoma

Apoptotic and Anti-metastatic Effects of Atractylodes lancea (Thunb.) DC. in a Hamster Model of Cholangiocarcinoma

Protocols for Glycosyltransferase Assays: Ganglioside Globoside and Lewis-X Intermediate-Lactosylceramide Biosyntheses in Eukaryotic Systems

Regulations of Glycolipid: XI. Glycosyltransferase (GSL: GLTs) Genes Involved in SA-LeX and Related GSLs Biosynthesis in Carcinoma Cells by Biosimilar Apoptotic Agents: Potential Anticancer Drugs

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