Apoptosis induction in human leukemic cells by a novel protein Bengalin, isolated from Indian black scorpion venom: Through mitochondrial pathway and inhibition of heat shock proteins

Gupta, Sanchita; Gomes, Antony; Debnath, Anindita; Saha, Archita

doi:10.1016/j.cbi.2009.11.006

Cited by 77 publications

(51 citation statements)

References 41 publications

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“…These results agree with previous reports that scorpion venom inhibited the growth of lymphoma (3,9), leukemia (10), neuroblastoma (4), gliomas (11)(12)(13), breast cancer (14) and prostate cancer (15,16).…”

Section: Discussionsupporting

confidence: 93%

Scorpion venom component III inhibits cell proliferation by modulating NF-κB activation in human leukemia cells

Song

Zhang

Sun

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. Scorpion venom contains various groups of compounds that exhibit anticancer activity against a variety of malignancies through a poorly understood mechanism. While the aberrant activation of nuclear factor κB (NF-κB) has been linked with hematopoietic malignancies, we hypothesized that scorpion venom mediates its effects by modulating the NF-κB signaling pathway. In the present study, we examined the effects of scorpion venom component III (SVCIII) on the human leukemia cell lines THP-1 and Jurkat and focused on the NF-κB signaling pathway. Our results showed that SVCIII inhibited cell proliferation, caused cell cycle arrest at G1 phase and inhibited the expression of cell cycle regulatory protein cyclin D1 in a dose-dependent manner in THP-1 and Jurkat cells. SVCIII also suppressed the constitutive NF-κB activation through inhibition of the phosphorylation and degradation of IκBα. NF-κB luciferase reporter activity was also inhibited by SVCIII. Our data suggest that SVCIII, a natural compound, may exert its antiproliferative effects by inhibiting the activation of NF-κB and, thus, has potential use in the treatment of hematopoietic malignancies, alone or in combination with other agents.

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Section: Discussionsupporting

confidence: 93%

Scorpion venom component III inhibits cell proliferation by modulating NF-κB activation in human leukemia cells

Song

Zhang

Sun

et al. 2012

Experimental and Therapeutic Medicine

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“…A number of antibacterial, antifungal (yeast) and antiviral substances have been derived from peptides isolated from scorpion venom (13,14). Additionally, scorpion venom has demonstrated anticancer potential in pancreatic cancer (15) and leukemia (16). Scorpion venom is constituted by a complex mixture of salts, nucleotides, biogenic amines, peptides, enzymes, mucoproteins and other proteins such as neurotoxins (17).…”

Section: Introductionmentioning

confidence: 99%

In vitro analysis of the anticancer properties of scorpion venom in colorectal and breast cancer cell lines

2015

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Abstract. Scorpion venom contains various types of proteins and peptides that are able to act as inhibitors of neurotransmitter molecules. This is achieved primarily via the inhibition of ion channels. In addition, scorpion venom has been demonstrated to exhibit anticancer properties in prostate and breast cancer, as well as leukemia. The anticancer properties of scorpion venom are due to its inhibitory effect on matrix metalloproteinase (MMP) activity, which leads to reduced motility and invasion in tumor cells. The inhibitory effects of venom on MMPs additionally lead to a reduction in the metastatic potential of malignant tumors. In the present study, the effect of venom obtained from a local serpentarium facility was examined in colorectal and breast cancer cell lines. Cell motility and clonogenic survival assays revealed a significant decrease (60-90%) in cell motility and colony formation, two significant hallmarks of cancer survival, following treatment with various concentrations of venom. These results were in agreement with previous studies demonstrating the anticancer activity of scorpion venom. In conclusion, the venom utilized at the Research Center of Prince Sultan Military Medical City Hospital (Riyadh, Saudi Arabia) possesses significant anticancer potential against colorectal and breast cancer cell lines.

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“…Recently, proteins, peptides and non-protein compounds with anticancer activities have been identified from animal venoms and some of them have been studied intensively (Heinen and da Veiga, 2011;Gupta et al, 2010;Liu et al, 2012). Here, the anticaner potential of the L. vittata venom was examined on the growth of PC-3, U937, K562, MDA-MB-231 cancer cell lines, using HEK293T as control.…”

Section: The Venom Inhibits the Growth Of Cancer Cellsmentioning

confidence: 99%

A survey of the venom of the spider Lycosa vittata by biochemical, pharmacological and transcriptomic analyses

Zhang

Liu

Tan

et al. 2015

Toxicon

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Lycosa vittata, mainly distributed in the southwest of China, is a medium-sized and venomous spider, whose venom remains unexplored so far. This study aims to present an overview of the venom. It mainly consisted of diverse peptides and exhibited inhibitory effects on voltage-gated ion channels in rat dorsal root ganglia neurons, with a strongest inhibition on tetrodotoxin-sensitive and tetrodotoxin-resistant voltage-gated Na(+) channels. Interestingly, it exerted cytotoxicity to cancer cells, with approximately 10-fold selectivity on PC-3 over others, implying the existence of selective anti-PC-3 agents in the venom. Moreover, 51 toxin-like peptides were deduced from the venom gland transcriptome. Bioinformatic analyses suggested their structures might have some distinguished properties and their predicted functions were consistent with the venom activities. This study suggests that the venom is an attractive source of neurotoxins with therapeutic significance, and provides references for the structure and function investigation of specific toxins in the future.

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Apoptosis induction in human leukemic cells by a novel protein Bengalin, isolated from Indian black scorpion venom: Through mitochondrial pathway and inhibition of heat shock proteins

Cited by 77 publications

References 41 publications

Scorpion venom component III inhibits cell proliferation by modulating NF-κB activation in human leukemia cells

Scorpion venom component III inhibits cell proliferation by modulating NF-κB activation in human leukemia cells

In vitro analysis of the anticancer properties of scorpion venom in colorectal and breast cancer cell lines

A survey of the venom of the spider Lycosa vittata by biochemical, pharmacological and transcriptomic analyses

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