Apoptosis induced by Moringa oleifera Lam. pod in mouse colon carcinoma model

Kraiphet, Suchada; Butryee, Chaniphun; Rungsipipat, Anudep; Budda, Sirintip; Rattanapinyopitak, Kasem; Tuntipopipat, Siriporn

doi:10.1007/s00580-017-2546-8

Cited by 9 publications

(23 citation statements)

References 26 publications

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“…β-carotene, the major component reported from the drumsticks of the M. oleifera plant as well as the presence of vitamin A and C suggest an action in the induction of antioxidant and anti-inflammatory profiles (Geervani and Devi 1981;Bharali et al 2003;Praengam et al 2014). It was suggested that β-carotene and sterols present in the plant pods acts as potent inhibitors on the formation of reactive oxygen intermediates, a pre-requisite for tumorigenesis and so inducing apoptosis in the mouse colon carcinoma model (Gupta et al 2010;Kraiphet et al 2018). Studies in rats showed that M. oleifera leaves extract might act as potential neuroprotectant via decreased oxidative stress and the enhanced cholinergic function (Kirisattayakul et al 2013) and function as a cognitive enhancer, hence being used in dementia cases (Sutalangka et al 2013).…”

Section: Leaves and Podsmentioning

confidence: 99%

A review of properties, nutritional and pharmaceutical applications of Moringa oleifera: integrative approach on conventional and traditional Asian medicine

Meireles

Gomes²,

Lopes

et al. 2020

ADV TRADIT MED (ADTM)

126

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Moringa oleifera L. from the Moringaceae family is a perennial tree widely cultivated in many tropic regions and easily grown even in adverse conditions. M. oleifera is also known as the miracle tree, which for centuries has been indicated for traditional medicine. With no reports of side effects, in doses achievable by ingestion, different parts of M. oleifera is used to treat several conditions, such as malnutrition, diabetes, blindness, anemia, hypertension, stress, depression, skin, arthritis, joints and kidney stones disorders. This plant also showed capacity of helping in maintenance of the cardiovascular system health, blood-glucose levels and providing anti-oxidant, anti-inflammatory and anti-cancer activity as well as the regulation of urinary tract and lactation in nursing women. The seed and leaves powder has water purification properties through flocculation. It also supplements the food in the human diet and in the fortification of livestock feed, especially in developing countries. So, M. oleifera properties have also been applied to cosmetic and byproducts industries due to the high nutritive and protective properties of its seed oil. According to the holistic or traditional medicine, M. oleifera has very relevant therapeutic properties and applications depending on the constitution, somatic and psychological needs of patients. It is usually referred as a natural product that can treat different physical and psychological health aspects, offering an energetic action and structural rebuilder of the body and promoting emotions of highly positive attitudes towards life. The high and specific immunological potential of M. oleifera leads us to suggest an in-depth study to assess the hypothesis of conferring a supportive effect against Covid-19 disease.

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Section: Leaves and Podsmentioning

confidence: 99%

A review of properties, nutritional and pharmaceutical applications of Moringa oleifera: integrative approach on conventional and traditional Asian medicine

Meireles

Gomes²,

Lopes

et al. 2020

ADV TRADIT MED (ADTM)

126

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“…The experimental diets were prepared by mixing bMO at concentrations of 1.5, 3.0 and 6.0% with the basal AIN-76 diet ( Table SI ). Animal diet preparation was prepared according to the protocol previously described ( 16 , 17 ). The bMO content in animal diets was equivalent to 10, 20 and 40 times of human consumption (Food consumption survey data of Thai population, 2006) ( 18 ).…”

Section: Methodsmentioning

confidence: 99%

“…The chemopreventive and therapeutic potential of bMO pods were demonstrated in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced mouse colon cancer. The results indicated that tumor formation and multiple tumors were significantly decreased in the AOM/DSS-induced mice receiving bMO compared with AOM/DSS-induced mice ( 16 , 17 ). The therapeutic efficacy of boiled MO was partially due to its ability to induce apoptotic cell death in colon tissues, by upregulating the pro-apoptotic protein Bax and decreasing the anti-apoptotic protein Bcl-2 expression ( 17 ).…”

Section: Introductionmentioning

confidence: 92%

“…The results indicated that tumor formation and multiple tumors were significantly decreased in the AOM/DSS-induced mice receiving bMO compared with AOM/DSS-induced mice ( 16 , 17 ). The therapeutic efficacy of boiled MO was partially due to its ability to induce apoptotic cell death in colon tissues, by upregulating the pro-apoptotic protein Bax and decreasing the anti-apoptotic protein Bcl-2 expression ( 17 ). Preventive treatment with bMO in mice reduced the expression of inflammatory mediators, inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) ( 16 ).…”

Section: Introductionmentioning

confidence: 92%

“…Although various parts of MO exhibit biological functions, MO pods have drawn considerable attention ( 15 – 17 ) as they are common ingredients in traditional Asian soups from Thailand, India and Philippines. Boiled MO (bMO) pods exhibited strong anti-inflammatory effects in LPS-induced murine macrophages ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

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Protein expression profiles that underpin the preventive and therapeutic potential of Moringa oleifera Lam against azoxymethane and dextran sodium sulfate‑induced mouse colon carcinogenesis

et al. 2020

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Previous studies in a mouse model have indicated the anticancer potential of boiled Moringa oleifera pod (bMO)-supplemented diets; however, its molecular mechanisms are still unclear. Therefore, the present study aimed to explore the protein expression profiles responsible for the suppressive effect of bMO supplementation on azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced mouse colon carcinogenesis. Analysis by gel electrophoresis and liquid chromatography-tandem mass spectrophotometry demonstrated that there were 125 proteins that were differentially expressed in mouse colon tissues between 14 experimental groups of mice. The differentially expressed proteins are involved in various biological processes, such as signal transduction, metabolism, transcription and translation. Venn diagram analysis of the differentially expressed proteins was performed in six selected mouse groups, including negative control, positive control mice induced by AOM/DSS, the AOM/DSS groups receiving preventive or therapeutic bMO diets and their bMO-supplemented control groups. This analysis identified 7 proteins; 60S acidic ribosomal protein P1 (Rplp1), fragile X mental retardation, cystatin 9, round spermatids protein, zinc finger protein 638, protein phosphatase 2C (Ppm1g) and unnamed protein product as being potentially associated with the preventive and therapeutic effects of bMO in AOM/DSS-induced mouse colon cancer. Analysis based on the search tool for interactions of chemicals (STITCH) database predicted that Rplp1 interacted with the apoptotic and inflammatory pathways, whereas Ppm1g was associated only with inflammatory networks. This proteomic analysis revealed candidate proteins that are responsible for the effects of bMO supplementation, potentially by regulating apoptotic and inflammatory signaling networks in colorectal cancer prevention and therapy.

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Expression of apoptotic proteins in the pulmonary artery of dogs with pulmonary hypertension secondary to degenerative mitral valve disease

Sakarin

Rungsipipat

Surachetpong

2022

Research in Veterinary Science

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Apoptosis induced by Moringa oleifera Lam. pod in mouse colon carcinoma model

Cited by 9 publications

References 26 publications

A review of properties, nutritional and pharmaceutical applications of Moringa oleifera: integrative approach on conventional and traditional Asian medicine

A review of properties, nutritional and pharmaceutical applications of Moringa oleifera: integrative approach on conventional and traditional Asian medicine

Protein expression profiles that underpin the preventive and therapeutic potential of Moringa oleifera Lam against azoxymethane and dextran sodium sulfate‑induced mouse colon carcinogenesis

Expression of apoptotic proteins in the pulmonary artery of dogs with pulmonary hypertension secondary to degenerative mitral valve disease

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