Apoptosis induced by membrane damage in human lymphocytes; effects of arachidonic acid and its photoproducts.

Zarebska, Z; Zielińska, Julia; Zhukov, Igor; Maśliński, Włodzimierz

doi:10.18388/abp.2005_3505

Cited by 3 publications

(1 citation statement)

References 35 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16 The irradiated molecules may produce radical oxygen species 17 that interfere with several signalling pathways modifying cellular functions and membrane structure, 18,19 and therefore can lead to cell death by inducing apoptosis. 20,21 Although much attention has been devoted to the study of psoralen-DNA interactions, 6,[22][23][24][25] the formation of photoadducts with other molecules like proteins, 26 unsaturated fatty acids or phospholipids [27][28][29][30][31][32] can also disrupt key cellular functions such as membrane function, organisation and integrity.…”

Section: Introductionmentioning

confidence: 99%

Properties and behaviour of tetracyclic allopsoralen derivatives inside a DPPC lipid bilayer model

Santos

Saenz‐Méndez²,

Eriksson

et al. 2011

Phys. Chem. Chem. Phys.

View full text Add to dashboard Cite

Allopsoralens are angular psoralen derivatives presenting advantages over the parent compound because of monofunctional DNA-photobinding and consequent lower toxicity. Allopsoralen molecules with three different substituents and different protonation states were studied using the molecular dynamics technique. The location of these molecules when inside the lipid bilayer is of major importance because their photochemical properties can change with the environment. Also, the ability of psoralens to form photoadducts with unsaturated phospholipids depends on the preference of the molecules to locate themselves closer to the bilayer middle were the double bond functionality can be found. Herein we show that the allopsoralens tend to accumulate inside the lipid bilayer closer to the water interface when protonated or closer to the interface middle otherwise. Allopsoralens containing one amine terminated carbon chain tend to have different rotational and orientational behaviour and an orientation preference close to the ones shown by the lipids. The size and chemical nature of the substituent also affect the molecular mobility and capacity to interact with water molecules and the nitrogen or phosphorus atoms of the lipids.

show abstract

Section: Introductionmentioning

confidence: 99%

Properties and behaviour of tetracyclic allopsoralen derivatives inside a DPPC lipid bilayer model

Santos

Saenz‐Méndez²,

Eriksson

et al. 2011

Phys. Chem. Chem. Phys.

View full text Add to dashboard Cite

show abstract

Targeting the enzymes involved in arachidonic acid metabolism to improve radiotherapy

Kim

Son

Lee

et al. 2018

Cancer Metastasis Rev

View full text Add to dashboard Cite

During radiotherapy, an inflammatory response might be induced by activating various enzymes involved in membrane lipid metabolism. The eicosanoid pathway associated with cytosolic phospholipase A2 (cPLA), cyclooxygenases (COXs), and lipoxygenases (LOXs) can be induced by radiation, and many lipid metabolites might contribute to cancer-associated inflammation, cell proliferation, and cell survival in cancer. The lipid metabolites are also involved in the establishment of the tumor-associated microenvironment through promotion of angiogenesis and formation of vascular network. These biological activities of lipid metabolites are responsible for malignant progression with the acquisition of radioresistance, leading to unsatisfactory outcome of cancer radiotherapy. Many efforts have been made to identify the mechanisms associated with bioactive lipid metabolites and radiation signaling that lead to radioresistance and to develop potent radiosensitizers to improve therapeutic efficacy. Beneficial outcomes would be achieved by targeting the enzymes, such as cPLA, COXs, and LOXs, responsible for arachidonic acid metabolism and cancer-associated inflammation during cancer radiotherapy. The current study demonstrated a brief review for the radioresistant effects of bioactive lipid metabolites and their enzymes in cancer and the radiosensitizing effects of inhibitors for the enzymes on cancer therapy.

show abstract

Platelet-Activating Factor Is Crucial in Psoralen and Ultraviolet A-Induced Immune Suppression, Inflammation, and Apoptosis

Wolf

Nghiem

Walterscheid

et al. 2006

The American Journal of Pathology

View full text Add to dashboard Cite

Psoralen plus UVA (PUVA) is used as a very effective treatment modality for various diseases, including psoriasis and cutaneous T-cell lymphoma. PUVA-induced immune suppression and/or apoptosis are thought to be responsible for the therapeutic action. However, the molecular mechanisms by which PUVA acts are not well understood. We have previously identified platelet-activating factor (PAF), a potent phospholipid mediator, as a crucial substance triggering ultraviolet B radiation-induced immune suppression. In this study, we used PAF receptor knockout mice, a selective PAF receptor antagonist, a COX-2 inhibitor (presumably blocking downstream effects of PAF), and PAF-like molecules to test the role of PAF receptor binding in PUVA treatment. We found that activation of the PAF pathway is crucial for PUVAinduced immune suppression (as measured by suppression of delayed type hypersensitivity to Candida albicans) and that it plays a role in skin inflammation and apoptosis. Psoralen and UVA (PUVA) photochemotherapy consists of the topical or oral application of a photosensitizing psoralen (ie, a furocoumarin compound), such as 8-methoxypsoralen, followed by exposure to photoactivating UVA light.

show abstract

Apoptosis induced by membrane damage in human lymphocytes; effects of arachidonic acid and its photoproducts.

Cited by 3 publications

References 35 publications

Properties and behaviour of tetracyclic allopsoralen derivatives inside a DPPC lipid bilayer model

Properties and behaviour of tetracyclic allopsoralen derivatives inside a DPPC lipid bilayer model

Targeting the enzymes involved in arachidonic acid metabolism to improve radiotherapy

Platelet-Activating Factor Is Crucial in Psoralen and Ultraviolet A-Induced Immune Suppression, Inflammation, and Apoptosis

Contact Info

Product

Resources

About