2003
DOI: 10.1161/01.cir.0000085164.13439.89
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Apoptosis Induced by Inhibition of Cyclic AMP Response Element–Binding Protein in Vascular Smooth Muscle Cells

Abstract: Background-The balance between apoptosis and proliferation of vascular smooth muscle cells (VSMCs) is believed to contribute to the vascular remodeling process. Cyclic AMP response element-binding protein (CREB) is a critical transcription factor for the survival of neuronal cells and T lymphocytes. However, the role of CREB in blood vessels is incompletely characterized. Methods and Results-Nuclear staining with Hoechst 33258 or propidium iodine showed an increase in apoptotic cells with activation of caspase… Show more

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Cited by 68 publications
(71 citation statements)
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“…10 In vivo labeling with BrdU (0.5 mg/kg), a thymidine analogue that was injected intraperitoneally 3 hours before preparation of the artery, was performed to identify replicating cells by detection of DNA synthesis. The incorporated BrdU was detected immunohistochemically with an anti-BrdU antibody (Cell proliferation kit, Amersham Pharmacia Biotech) as described previously.…”
Section: Detection Of Apoptosis and Dna Synthesis In Vivomentioning
confidence: 99%
See 3 more Smart Citations
“…10 In vivo labeling with BrdU (0.5 mg/kg), a thymidine analogue that was injected intraperitoneally 3 hours before preparation of the artery, was performed to identify replicating cells by detection of DNA synthesis. The incorporated BrdU was detected immunohistochemically with an anti-BrdU antibody (Cell proliferation kit, Amersham Pharmacia Biotech) as described previously.…”
Section: Detection Of Apoptosis and Dna Synthesis In Vivomentioning
confidence: 99%
“…The incorporated BrdU was detected immunohistochemically with an anti-BrdU antibody (Cell proliferation kit, Amersham Pharmacia Biotech) as described previously. 10 …”
Section: Detection Of Apoptosis and Dna Synthesis In Vivomentioning
confidence: 99%
See 2 more Smart Citations
“…ATF5, encoded by ATF5 gene, belongs to the ATF/cyclic adenosine monophosphate response-element binding (CREB) protein family (40). CREB has been reported to serve a role in modulating the apoptosis and proliferation of vascular smooth muscle cells (41,42).…”
Section: Discussionmentioning
confidence: 99%