Apoptosis Induced by Influenza Virus-Hemagglutinin Stimulation may be Related to Fluctuation of Cellular Oxidative Condition.

Ohyama, Kunio; Nishina, Manabu; Yuan, Bo; Bessho, Toshio; Yamakawa, Toshio

doi:10.1248/bpb.26.141

Cited by 13 publications

(8 citation statements)

References 32 publications

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“…We also suggest that when the levels of oxidative stress exceed threshold levels for the amnion cells, HO-1 gene expression is quickly induced and compensate for the dysfunction of antioxidant system resulting in the protection for the cells. In fact, we previously reported that pre-stimulation of amnion cells with hemin, a HO-1 inducer, significantly attenuated influenza virus-HA induced apoptosis (Ohyama et al, 2003).…”

Section: Discussionmentioning

confidence: 97%

Imbalance between ROS production and elimination results in apoptosis induction in primary smooth chorion trophoblast cells prepared from human fetal membrane tissues

Yuan

Ohyama

Bessho³

et al. 2008

Life Sciences

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Section: Discussionmentioning

confidence: 97%

Imbalance between ROS production and elimination results in apoptosis induction in primary smooth chorion trophoblast cells prepared from human fetal membrane tissues

Yuan

Ohyama

Bessho³

et al. 2008

Life Sciences

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“…However, any influences of influenza virus infection on a maternal body and on the pregnancy retaining are still unknown. As we demonstrated that the IV-infection induced apoptotic phenomena were associated with viral macromolecular synthesis in host cells, 8) and that a viral constituent, a hemagglutinin resulted in the induction of apoptosis in fetal cells through an oxidative stress production, 9) we investigated the molecular mechanism of the apoptotic induction in human uterine cell line, HCF, caused by influenza virus type A (IV-A) or type B (IV-B) infection for studying apoptotic effect of the infection in maternal body and some roles of the apoptosis induction in its defense mechanism.…”

mentioning

confidence: 79%

Predominant Contribution of IFN-.BETA. Expression to Apoptosis Induction in Human Uterine Cervical Fibroblast Cells by Influenza-Virus Infection

Ohyama

Sano

Toyoda

2004

Biological & Pharmaceutical Bulletin

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“…During natural HIV-1 infection, much of the envelope is shed from the cell surface as Env gp120 monomers [21,60] and Env gp120 has been associated with increased apoptosis of susceptible cells [18,27,74,81], as well as alterations of the permeability of the blood-brain barrier [23,93]. In addition, HIV-1 Env gp120 induces apoptosis in susceptible by-stander cells [66,72]. SIV also inhibit T cell proliferation and induce apoptosis [19].…”

Section: Discussionmentioning

confidence: 99%

Reduction of Anti-HIV-1 Gag Immune Responses During Co-Immunization: Immune Interference by the HIV-1 Envelope

Toapanta

Craigo²,

Montelaro³

et al. 2007

CHR

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Immunization with more than one immunogen (co-immunization) is an efficient regimen to induce immunity to multiple antigens. However, immune interference has been reported using multi-plasmid DNA immunizations. HIV-1 envelope (Env) and Gag gene products are the predominant immunogens used in current AIDS vaccines, although, few studies have evaluated possible immune interference when these two antigens are co-administered. Therefore, in this study, immune interference during co-inoculation was examined using DNA vaccines expressing lentiviral Envs and Gag from gene sequences optimized for efficient expression in mammalian cells (codon-optimized). BALB/c mice vaccinated in separate hind legs with each plasmid individually elicited high titer immune responses, however, when HIV-1 Env(gp120) and HIV-1 Gag(p55) DNA plasmids were co-inoculated, there was a reduction in the immune responses elicited to HIV-1 Gag(p55). To determine if the anti-HIV-1 Gag(p55) immune interference was specific to HIV-1 Env(gp120), mice were co-immunized with plasmids expressing the surface envelope protein from two additional lentiviruses, Env(gp130)-SIV or Env(gp90)-EIAV, or a soluble form of hemagglutinin (sHA) from influenza virus and HIV-1 Gag(p55)- or SIV Gag(p55)-DNA. Interestingly, there was no reduction in anti-HIV-1 Gag(p55) immune responses using other lentiviral envelopes or the influenza sHA. Also, none of the lentiviral envelopes reduced anti-SIV Gag(p55) immune responses during co-immunization. Therefore, anti-HIV-1 Gag immune interference appears specific to co-immunizations with HIV-1 Env(gp120) and may involve a yet undefined immunological mechanism(s).

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Apoptosis Induced by Influenza Virus-Hemagglutinin Stimulation may be Related to Fluctuation of Cellular Oxidative Condition.

Cited by 13 publications

References 32 publications

Imbalance between ROS production and elimination results in apoptosis induction in primary smooth chorion trophoblast cells prepared from human fetal membrane tissues

Imbalance between ROS production and elimination results in apoptosis induction in primary smooth chorion trophoblast cells prepared from human fetal membrane tissues

Predominant Contribution of IFN-.BETA. Expression to Apoptosis Induction in Human Uterine Cervical Fibroblast Cells by Influenza-Virus Infection

Reduction of Anti-HIV-1 Gag Immune Responses During Co-Immunization: Immune Interference by the HIV-1 Envelope

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