Apoptosis induced by extracellular ATP in the mouse neuroblastoma cell line N1E-115: studies on involvement of P2 receptors and adenosine

Functional significance of the negative-feedback regulation of ATP release via pannexin-1 hemichannels under ischemic stress in astrocytes

“…P2X 7 Rs are permeable to larger molecules up to 800-900 Da (Surprenant et al, 1996), and several studies have been shown that prolonged activation of P2X 7 Rs leads to cellular death (Atkinson et al, 2004;Schrier et al, 2002).…”

Growth inhibitory effect and apoptosis induced by extracellular ATP and adenosine on human gastric carcinoma cells: involvement of intracellu-lar uptake of adenosine1

“…It is well known that extracellular ATP and ADO have widespread effects on physiologic activities and play important physiologic and pathophysiologic roles in the cardiovascular system. Recently, they have been implicated in the induction of apoptosis in several cancer cell types such as human histiocytic leukemia cell line U-937 [2] , the mouse neuroblastoma cell line N1E-115 [3][4] , pancreatic cancer cells [5] , colorectal carcinoma cells [6] , prostate carcinoma cells [7] , rat pheochromocytoma cells [8][9] , and so on.…”

Connexin-related signaling in cell death: to live or let die?

“…131 A second level where HCs can influence the balance between cell death and survival involves a paracrine communication component. The release of metabolites such as ATP, glutamate or prostaglandins through HCs combined with their extracellular diffusion and action (directly or through break-down products like adenosine) 143 26,35,38,126,152 In a model of cochlear explant cultures, the local infliction of a cell-damaging stimulus caused a spatiotemporal spread of cell death in hair cells that was related to ERK1/2 activation, dependent on the associated intercellular Ca 2 þ wave and ATP release, and inhibited by carbenoxolone. 155 Once released, ATP is rapidly degraded to adenosine which displays both neuroprotective and -toxic properties.…”

“…155 Once released, ATP is rapidly degraded to adenosine which displays both neuroprotective and -toxic properties. 143,144 Combined in vitro and in vivo studies have demonstrated that ischemic pre-conditioning in the brain promotes ATP efflux through HCs and thereby protects against a second exposure to ischemic conditions through adenosine. 156 Another messenger released through HCs is glutamate, a well-documented paracrine messenger of cell death in the brain.…”