1998
DOI: 10.1590/s1415-47571998000100005
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Apoptosis in Trypanosomatids: Evolutionary and phylogenetic considerations

Abstract: Programmed cell death (PCD) or apoptosis, an active process of cell death, plays a central role in normal tissue development and organogenesis, as well as in the pathogenesis of different diseases. Although it occurs in diverse cells and tissues under the influence of a remarkable variety of inducing agents, the resultant ultrastructural and biochemical changes are extremely monotonous, indicating the existence of a common biological mechanism underlying its occurrence. It is generally accepted that a developm… Show more

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Cited by 3 publications
(2 citation statements)
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“…According to this same investigator, in spite of the occurrence of apoptosis in unicellular organisms, PCD as a developmentally regulated program is a prerogative of multicellular organisms. Our postulate is that multicellularity indeed underlies the occurrence of PCD but not necessarily in a single multicellular organism, rather, it can occur in any situation where living cells have developed structured relationships and division of functions (6,15). Such organization is compatible with several different features of the life cycle of heteroxenic trypanosomatids (16)(17)(18), and with their clonal population structure (19).…”
Section: Apoptosis In Unicellular Pathogenic Protozoan Parasitesmentioning
confidence: 92%
“…According to this same investigator, in spite of the occurrence of apoptosis in unicellular organisms, PCD as a developmentally regulated program is a prerogative of multicellular organisms. Our postulate is that multicellularity indeed underlies the occurrence of PCD but not necessarily in a single multicellular organism, rather, it can occur in any situation where living cells have developed structured relationships and division of functions (6,15). Such organization is compatible with several different features of the life cycle of heteroxenic trypanosomatids (16)(17)(18), and with their clonal population structure (19).…”
Section: Apoptosis In Unicellular Pathogenic Protozoan Parasitesmentioning
confidence: 92%
“…A apoptose é um tipo de autodestruição celular que requer energia e síntese proteica para a sua execução, e exerce um papel oposto ao da mitose 266 . A mitocôndria tem a habilidade de desencadear a apoptose, liberando para o citoplasma proteínas pró-apoptóticas(BAX e BcloXL) 267 .…”
Section: Ensaio De Apoptose (Anexina V)unclassified