Apoptosis in thymus of teleost fish

Romano, Nicla; Ceccarelli, Giuseppina; Caprera, Cecilia; Caccia, Elisabetta; Baldassini, Maria Rosaria; Marino, G.

doi:10.1016/j.fsi.2013.04.005

Cited by 11 publications

(4 citation statements)

References 21 publications

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“…Similarly, the present study showed the up-regulation of the HSP70 in the thymus of L. anguillarum-infected fish. The thymus represents in sea bass a specialized microenvironment for T cells maturation and differentiation (Bagni et al, 2005;Picchietti et al, 2009;Romano et al, 2011Romano et al, , 2013 and the expression of HSP70 in this compartment may reveal a regulatory activity after L. anguillarum infection, as suggested in the present study, or following vaccination, as highlighted in a previous study .…”

Section: Discussionsupporting

confidence: 73%

Defensive response of European sea bass (Dicentrarchus labrax) against Listonella anguillarum or Photobacterium damselae subsp. piscicida experimental infection

Mosca

Ciulli

Volpatti

et al. 2014

Veterinary Immunology and Immunopathology

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Section: Discussionsupporting

confidence: 73%

Defensive response of European sea bass (Dicentrarchus labrax) against Listonella anguillarum or Photobacterium damselae subsp. piscicida experimental infection

Mosca

Ciulli

Volpatti

et al. 2014

Veterinary Immunology and Immunopathology

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“…Moreover, the immunohistochemical technique for the detection of active caspase-3, an effector protease in the apoptotic process, indicated an increased presence of this protein. Thymocytes physiologically undergo apoptosis during the processes of positive and negative selection [48], and our results point towards an increased apoptosis rate in turbot infected by E. scophthalmi. However, the mechanisms by which this process is activated and the extent of its role in the development of thymus atrophy should be carefully investigated.…”

Section: Discussionsupporting

confidence: 63%

The Teleost Thymus in Health and Disease: New Insights from Transcriptomic and Histopathological Analyses of Turbot, Scophthalmus maximus

Ronza

Robledo

Losada

et al. 2020

Biology

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The thymus is a primary lymphoid organ that plays a pivotal role in the adaptive immune system. The immunobiology of the thymus in fish is considered to be similar to that of mammals, but it is actually poorly characterized in several cultured teleost species. In particular, while investigations in human and veterinary medicine have highlighted that the thymus can be affected by different pathological conditions, little is known about its response during disease in fish. To better understand the role of the thymus under physiological and pathological conditions, we conducted a study in turbot (Scophthalmus maximus), a commercially valuable flatfish species, combining transcriptomic and histopathological analyses. The myxozoan parasite Enteromyxum scophthalmi, which represents a major challenge to turbot production, was used as a model of infection. The thymus tissues of healthy fish showed overrepresented functions related to its immunological role in T-cell development and maturation. Large differences were observed between the transcriptomes of control and severely infected fish. Evidence of inflammatory response, apoptosis modulation, and declined thymic function associated with loss of cellularity was revealed by both genomic and morphopathological analyses. This study presents the first description of the turbot thymus transcriptome and provides novel insights into the role of this organ in teleosts’ immune responses.

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“…Immature T cells are subjected to a RAG-dependent recombination of the TCR genes in the thymus' cortex and face both positive and negative selection through extensive interaction with epithelial cells (13). Apoptosis, or programmed cell death, plays a crucial role in the strict intrathymic selection of unsuitable T cell candidates (7), and as a consequence, there is considerable apoptotic activity in the thymus (14).…”

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confidence: 99%

Transcriptional Characterization of the T Cell Population within the Salmonid Interbranchial Lymphoid Tissue

Bergva

Austbø

König

et al. 2014

The Journal of Immunology

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Previously, our group has shown that the interbranchial lymphoid tissue (ILT) is a distinct structure largely consisting of T cells embedded in a meshwork of epithelial cells, with no direct resemblance to previously described lymphoid tissues. In this study, we aim to focus on the T cell population and the possibility of the ILT being a thymus analog. By characterizing structural responsiveness to Ag challenge, the presence of recombination activating genes, and different T cell–related transcripts, we attempt to further approach the immunological function of the ILT in salmonid gills. In addition to eight healthy individuals, a group of eight infectious salmon anemia virus–challenged fish were included to observe T cell responses related to infection. The results showed reduced size of ILT in the infected group, no expression of RAG-1 and -2, and a high degree of T cell diversity within the ILT. Taking into account that the ILT can be regarded as a strategically located T cell reservoir and possibly an evolutionary forerunner of mammalian MALTs right at the border to the external environment, the alteration in transcription observed may likely represent a shift in the T cell population to optimize local gill defense mechanisms.

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Apoptosis in thymus of teleost fish

Cited by 11 publications

References 21 publications

Defensive response of European sea bass (Dicentrarchus labrax) against Listonella anguillarum or Photobacterium damselae subsp. piscicida experimental infection

Defensive response of European sea bass (Dicentrarchus labrax) against Listonella anguillarum or Photobacterium damselae subsp. piscicida experimental infection

The Teleost Thymus in Health and Disease: New Insights from Transcriptomic and Histopathological Analyses of Turbot, Scophthalmus maximus

Transcriptional Characterization of the T Cell Population within the Salmonid Interbranchial Lymphoid Tissue

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