Apoptosis in the Uterus of Mice with Pregnancy Loss

Savion, Shoshana; Lepsky, E.; Orenstein, Hasida; Carp, Howard; Shepshelovich, Jeanne; Torchinsky, Arkady; Fein, Amos; Toder, V.

doi:10.1034/j.1600-0897.2002.1o027.x

Cited by 52 publications

(37 citation statements)

References 25 publications

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“…Increasing studies have demonstrated that RSA is associated with a high level of cell apoptosis [18] . As a well-known inducer of cell apoptosis [19] , the Pro polymorphism of codon 72, which affects the activity of p53, may serve as a susceptibility factor of RSA [11] .…”

Section: Discussionmentioning

confidence: 99%

Association between p53 polymorphism at codon 72 and recurrent spontaneous abortion

Zhang

Qiao

2016

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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p53 gene plays an important role in apoptosis, which is necessary for successful invasion of trophoblast cells. The change from an arginine (Arg) to a proline (Pro) at codon 72 can influence the biological activity of p53, which predisposes to an increased risk of recurrent spontaneous abortion (RSA). In order to investigate the association between p53 polymorphism at codon 72 and RSA, we conducted this meta-analysis. Pubmed, Embase and Web of science were used to identify the eligible studies. Odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the strength of the association. Six studies containing 937 cases of RSA and 830 controls were included, and there was one study deviated from Hardy-Weinberg equilibrium (HWE). There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not. A significant association was observed in allelic model (Pro vs. Arg; OR=1.28, 95% CI: 1.04-1.57) after exclusion of the study that was deviated from HWE. No association was noted in recessive model (Pro/Pro+Pro/Arg vs. Arg/Arg; OR=1.05, 95% CI: 0.86-1.30) and co-dominant model (Pro/Arg vs. Arg/Arg; OR=0.96, 95% CI: 0.77-1.19). Subgroup analysis by ethnicity also indicated a significant association between p53 polymorphism at codon 72 and RSA in Caucasian group. No heterogeneity and publication bias were found. Our meta-analysis implied that p53 polymorphism at codon 72 carries high maternal risk of RSA.

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Section: Discussionmentioning

confidence: 99%

Association between p53 polymorphism at codon 72 and recurrent spontaneous abortion

Zhang

Qiao

2016

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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“…A number of proteins involved in trophoblastic invasion and angiogenesis have been identified. One such protein is p53, a tumor suppressor, a potent inducer of apoptosis and angiogenesis [5]. Low expression of apoptosis and angiogenesis related genes have been associated with implantation failure [3].…”

Section: Introductionmentioning

confidence: 99%

Negative effect of P72 polymorphism on p53 gene in IVF outcome in patients with repeated implantation failure and pregnancy loss

Lledó

Turienzo

Ortíz

et al. 2013

J Assist Reprod Genet

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Purpose Investigate whether R72P on p53 gene polymorphism has a higher prevalence among women with a history of recurrent implantation failure (RIF) and pregnancy loss (RPL) and its influence in their IVF cycle outcome. Material and methods p53 polymorphism R72P has been studied in 181 women. The control group included 83 oocyte donors. In the study group 98 women were included: 44 with RIF and 54 with RPL. From the study group, 76 patients underwent IVF-cycles (55 RPL and 21 RIF). Results The frequency of PP genotypes on p53 among RIF was 11.4 % compared with 18.5 % for RPL and 6 % in controls (p <0.01). There were no significant differences with respect to patient characteristics. Significant differences were reported in pregnancy rate (69.4 % for RR/RP and 33.3 % for PP; p < 0.05), embryo implantation rate (33.3 % for RR/RP and 7.3 % for PP; p <0.05) and ongoing pregnancy rate (53.1 % for RR/ RP and 14.3 % for PP; p <0.05) among RIF and RPL. Conclusions This investigation reveals that in RIF and RPL patients R72P on p53 gene is more prevalent than fertile population. Moreover, patients carrying a PP genotype on p53 codon 72 will have less chance to achieve an ongoing pregnancy. This information together with some additional markers will allow development of diagnostic tests for detects risk for RIF and RPL before infertility treatment is initiated.

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“…Activation of MMPs at the implantation site is stimulated by the serine protease plasmin, the production of which is regulated by plasminogen activator inhibitors (PAI) (5). The p53 tumor suppressor gene is a potent inducer of apoptosis, regulates cell growth, and induces angiogenesis (6,7). Vascular endothelial growth factor (VEGF) is the best characterized regulator of angiogenesis (8).…”

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confidence: 99%

P53 tumor suppressor factor, plasminogen activator inhibitor, and vascular endothelial growth factor gene polymorphisms and recurrent implantation failure

Goodman

Jeyendran²,

Coulam

2009

Fertility and Sterility

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Apoptosis in the Uterus of Mice with Pregnancy Loss

Abstract: Our results suggest a possible role for the apoptotic process in mechanisms mediating pregnancy loss and indicate an involvement of p53 and bcl-2 in its regulation.

Cited by 52 publications

References 25 publications

Association between p53 polymorphism at codon 72 and recurrent spontaneous abortion

Association between p53 polymorphism at codon 72 and recurrent spontaneous abortion

Negative effect of P72 polymorphism on p53 gene in IVF outcome in patients with repeated implantation failure and pregnancy loss

P53 tumor suppressor factor, plasminogen activator inhibitor, and vascular endothelial growth factor gene polymorphisms and recurrent implantation failure

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