Apoptosis in follicles of individuals with female pattern hair loss is associated with perifollicular microinflammation

Ramos, Paulo Müller; Brianezi, Gabrielli; Martins, Augusto; Silva, Márcia Guimarães da; Marques, Mea; Miot, Hélio Amante

doi:10.1111/ics.12341

Cited by 38 publications

(22 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The quality of hair shaft and the hair growth may thus be altered , and as the ROS‐detoxifying enzyme tyrosinase‐related protein 2 (TRP2) is not expressed in the hair bulb, the pigmentation process is progressively disturbed, and the hair fibre is greying . The involvement of a micro‐inflammatory cascade in androgenic alopecia has also been pointed out for years , inflammatory cells surround the permanent region of the follicle producing a damaging environment for stem cells . In addition, in vitro studies showed that oxidative stress reduced hair matrix cell proliferation and increased cell apoptosis .…”

Section: Discussionmentioning

confidence: 99%

A combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol stabilizes hypoxia‐inducible factor 1‐alpha and improves hair density in female volunteers

Juchaux

Sellathurai

Perrault

et al. 2020

Intern J of Cosmetic Sci

View full text Add to dashboard Cite

Objective The aim of this study was first to demonstrate that a combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol could synergize in vitro on biological pathways associated with hair growth and then to demonstrate the benefit on hair density in a clinical study. Methods The effects of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol directly on the hypoxic inducible factor‐1α protein (HIF‐1α) and related genes expression were demonstrated on keratinocytes in culture in vitro using western‐blot analysis and real time quantitative polymerase chain reaction analysis. The effect of resveratrol against oxidative stress induced by hydrogen peroxide treatment was studied in hair follicle and hair matrix cells in vitro using the sensitive probe Dichloro‐dihydro‐fluorescein diacetate (DCFH‐DA). Finally, a randomized clinical study on hair density was conducted on 79 Caucasian female subjects to assess the effect of this combination of actives. Results Pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol stabilized HIF‐1a protein and increased the expression of HIF‐1α target genes. Resveratrol significantly reduced the oxygen peroxide‐induced oxidative stress generated in hair follicle and hair matrix cells. The clinical study showed that a topical treatment with the combination significantly increased the hair density on women from 1.5 months. Conclusion In addition to the antioxidant properties of resveratrol, the association of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol revealed a synergistic effect on the HIF‐1α pathway. The results of the clinical study confirmed the importance of such a combination to increase the hair density.

show abstract

Section: Discussionmentioning

confidence: 99%

A combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol stabilizes hypoxia‐inducible factor 1‐alpha and improves hair density in female volunteers

Juchaux

Sellathurai

Perrault

et al. 2020

Intern J of Cosmetic Sci

View full text Add to dashboard Cite

show abstract

“…Later, Whiting reported the presence of inflammation in 37% of biopsy samples from patients with FPHL compared with 12% of control subjects. Scalp biopsies from 17 women with FPHL and five healthy females were included in the study of Ramos et al . They observed a higher apoptosis index and prominent mononuclear microinflammation among the miniaturized follicles.…”

Section: Pathophysiologymentioning

confidence: 99%

Genetics and other factors in the aetiology of female pattern hair loss

Redler

Messenger

Betz

2017

Experimental Dermatology

View full text Add to dashboard Cite

Pattern hair loss is the most common form of hair loss in both women and men. Male pattern hair loss, also termed male androgenetic alopecia (M-AGA), is an androgendependent trait that is predominantly genetically determined. Androgen-mediated mechanisms are probably involved in female pattern hair loss (FPHL) in some women but the evidence is less strong than in M-AGA; other non-androgenic pathways, including environmental influences, may contribute to the aetiology. Genome-wide association studies have identified several genetic loci for M-AGA and have provided better insight into the underlying biology. However, the role of heritable factors in and it has long been assumed that FPHL shares the same aetiology;hence, the term "female androgenetic alopecia" is often applied to this condition. However, the role of androgens in causing FPHL is less clear than in men. The genetic studies performed so far have not led to any firm conclusions but rather suggest different pathways for M-AGA and FPHL.In this review, we summarize what is known about the aetiology of FPHL and its relationship to M-AGA. Our main focus is on the results of genetic studies performed within the last decade. We also discuss the role of endocrine and other factors in the pathogenesis. | PREVALENCEPublished data on the prevalence of FPHL show some variation between studies, perhaps reflecting the difficulty in classifying mild forms of the condition. However, all show an increasing prevalence with age. Studies in women of white European ethnicity in the USA, [2] UK [3] and Australia [4] record a prevalence of 3%-12% in the third decade, rising to 14%-28% in the sixth decade and 29%-56%

show abstract

“…DHT, which present 10 times more affinity to androgen receptors compared to testosterone, binds to these receptors in genetically predisposed hair follicles, impairing hair cycle. The landmark decrease of anagen phase occur, anticipating catagen phase in a complex process involving apoptosis as probably microinflammation [10,25]. The involvement of hair follicle microinflammation in AGA is being reported since the 1970s.…”

Section: Pathophysiology Of Agmentioning

confidence: 99%

“…Fibroblasts also respond to pro-inflammatory factors [35] and cellular defenses (neutrophils, T cells, Langerhans cells) are mobilized [36,37]. The inflammation usually persists and may lead to tissue remodeling via collagenases, generating a perifollicular fibrosis [10] and also to apoptosis that has been recently related to follicle miniaturization [25].…”

Section: Pathophysiology Of Agmentioning

confidence: 99%

Androgenic alopecia and dutasteride in hair mesotherapy: A short review

Busanello¹,

Turcatel²

2018

Our Dermatol Online

View full text Add to dashboard Cite

Apoptosis in follicles of individuals with female pattern hair loss is associated with perifollicular microinflammation

Abstract: Apoptosis was prominent in hair follicles from the FPHL group, as well as in miniaturized ones. Moreover, it was also correlated with the inflammatory infiltrate, which suggests that inflammation can lead to apoptosis and play a role in the pathogenesis of follicle miniaturization.

Cited by 38 publications

References 11 publications

A combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol stabilizes hypoxia‐inducible factor 1‐alpha and improves hair density in female volunteers

A combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol stabilizes hypoxia‐inducible factor 1‐alpha and improves hair density in female volunteers

Genetics and other factors in the aetiology of female pattern hair loss

Androgenic alopecia and dutasteride in hair mesotherapy: A short review

Contact Info

Product

Resources

About