1998
DOI: 10.1002/(sici)1097-0185(199807)251:3<286::aid-ar2>3.0.co;2-u
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Apoptosis in cavitation of middle ear space

Abstract: Mesenchyme cells surround early ossicles in the developing middle ear, then are replaced by space that is created by what has been described as an expansion of the pharyngeal pouch. Cell death has not been considered important in cavitation of chick middle ear (Jaskoll and Maderson [1978] Anat. Rec., 190:177-200), but an uncharacterized form of cell death has been reported to play a major role in cavitation of mouse middle ear (Jaskoll [1977] PhD thesis, CUNY). We investigated whether this uncharacterized cell… Show more

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Cited by 13 publications
(2 citation statements)
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“…Before day 6, the external earflap (pinna) was folded in both wild-type and Eya4 -/-mice, providing a protective barrier, and the middle ear cavity was filled with mesenchymal cells, as has been previously reported (23). There was no delay in the onset of middle ear cavitation (24), which became evident at day 6, and no inflammation in the newly formed small middle ear space in wild-type or Eya4 -/-mice ( Figure 3A). At days 11-12, when the pinna was unfolded in all mice, the middle ear cavity was largely aerated and mesenchymal cells were found only near ossicles in wild-type mice.…”
Section: Production Of Eya4-deficient Mice the Endogenous Eya4 Gene Wassupporting
confidence: 69%
“…Before day 6, the external earflap (pinna) was folded in both wild-type and Eya4 -/-mice, providing a protective barrier, and the middle ear cavity was filled with mesenchymal cells, as has been previously reported (23). There was no delay in the onset of middle ear cavitation (24), which became evident at day 6, and no inflammation in the newly formed small middle ear space in wild-type or Eya4 -/-mice ( Figure 3A). At days 11-12, when the pinna was unfolded in all mice, the middle ear cavity was largely aerated and mesenchymal cells were found only near ossicles in wild-type mice.…”
Section: Production Of Eya4-deficient Mice the Endogenous Eya4 Gene Wassupporting
confidence: 69%
“…Further evidence to support this comes from work in the opossum and in humans where the volume of mesenchyme within the middle ear at various times was calculated and found to remain the same (Piza et al 1998). Additionally, no extensive apoptosis has ever been detected within the middle ear mesenchyme that would explain the clearance (Roberts & Miller, 1998). The dual origin of the middle ear epithelium is unique to mammals, and the development of the threeossicle mammalian middle ear may have lead to its evolution (Thompson & Tucker, 2013).…”
Section: Middle Ear Cavity Formationmentioning
confidence: 98%