Apoptosis factors caspases and p53 and their impact in chronic rhinosinusitis with nasal polyposis

Valera, Fabiana; Küpper, Daniel; Malinsky, Rafael Rossell; Milanezi, Cristiane M.; Silva, João; Tamashiro, Edwin; Anselmo‐Lima, Wilma Terezinha

doi:10.1186/2045-7022-3-s2-o20

Clinical & Translational All

2013

DOI: 10.1186/2045-7022-3-s2-o20

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Apoptosis factors caspases and p53 and their impact in chronic rhinosinusitis with nasal polyposis

Fabiana Valera

Daniel Küpper

Rafael Rossell Malinsky

et al.

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2020

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“…Moreover, the occurrence of DNS was usually accompanied by various breathing problems, including sinusitis allergic rhinitis and so on. Valera, Küpper et al observed significantly lower expression of apoptotic factors including p53, caspases 3 and 9 genes in chronic rhinosinusitis with nasal polyps patients compared with control group(20). Another study proved that delayed cellular apoptosis is implicated in the pathogenesis of nasal polyps(21).…”

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confidence: 97%

A genome-wide association study of deviated nasal septum using UK Biobank cohort

Liu¹,

Wu²,

Dai³

et al. 2020

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Background Deviated nasal septum (DNS) is a common otolaryngology disease. The genetic mechanism underlying DNS remains largely unknown. Methods Totally, 2, 978 DNS patients and 2,978 randomly selected controls from the UK biobank were used in this study. Genotyping was done using the Affymetrix UK BiLEVE Axiom or UK Biobank Axiom array. Genome-wide association study (GWAS) was performed by PLINK 2.0, using age, sex, population structure PC1, PC2 and PC3 as covariates. eQTLs analysis and gene set enrichment analysis (GSEA) were also performed to explore the functional relevance of identified loci with DNS. Results GWAS identified multiple candidate genetic loci for DNS, such as rs75651247 located in DLGAP1 (β=-5.3398, P=9.31×10-8), rs141366706 located in CCND3 (β=-4.7036, P=2.56×10-6), rs76606504 located in FAF1 (β=-4.5013, P=6.76×10-6), and rs142537880 located in SVIL (β= 4.4336, P=9.27×10-6). GSEA detected multiple DNS associated gene sets or pathways, such as KEGG_CALCIUM_SIGNALING_PATHWAY (FDR=3.35×10-3, P=5×10-5) and DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP (FDR=1.60×10-3, P=5×10-5). Conclusions Our study reported multiple candidate genes and gene sets for DNS, providing novel clues for understanding the genetic mechanism of DNS.

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mentioning

confidence: 97%

A genome-wide association study of deviated nasal septum using UK Biobank cohort

Liu¹,

Wu²,

Dai³

et al. 2020

Preprint

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Apoptosis factors caspases and p53 and their impact in chronic rhinosinusitis with nasal polyposis

Cited by 1 publication

References 0 publications

A genome-wide association study of deviated nasal septum using UK Biobank cohort

A genome-wide association study of deviated nasal septum using UK Biobank cohort

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