Apoptosis Exerts a Vital Role in the Treatment of Colitis-Associated Cancer by Herbal Medicine

Abstract

Colitis-associated cancer (CAC) is known as inflammatory bowel disease (IBD)-developed colorectal cancer, the pathogenesis of which involves the occurrence of apoptosis. Western drugs clinically applied to CAC are often single-targeted and exert many adverse reactions after long-term administration, so it is urgent to develop new drugs for the treatment of CAC. Herbal medicines commonly have multiple components with multiple targets, and most of them are low-toxicity. Some herbal medicines have been reported to ameliorate CAC through inducing apoptosis, but there is still a lack of systematic review. In this work, we reviewed articles published in Sci Finder, Web of Science, PubMed, Google Scholar, CNKI, and other databases in recent years by setting the keywords as apoptosis in combination with colitis-associated cancer. We summarized the herbal medicine extracts or their compounds that can prevent CAC by modulating apoptosis and analyzed the mechanism of action. The results show the following. (1) Herbal medicines regulate both the mitochondrial apoptosis pathway and death receptor apoptosis pathway. (2) Herbal medicines modulate the above two apoptotic pathways by affecting signal transductions of IL-6/STAT3, MAPK/NF-k B, Oxidative stress, Noncanonical TGF-b1, WNT/b-catenin, and Cell cycle, thereby ameliorating CAC. We conclude that following. (1) Studies on the role of herbal medicine in regulating apoptosis through the Ras/Raf/ERK, WNT/b-catenin, and Cell cycle pathways have not yet been carried out in sufficient depth. (2) The active constituents of reported anti-CAC herbal medicine mainly include polyphenols, terpenoids, and saccharide. Also, we identified other herbal medicines with the constituents mentioned above as their main components, aiming to provide a reference for the clinical use of herbal medicine in the treatment of CAC. (3) New dosage forms can be utilized to elevate the targeting and reduce the toxicity of herbal medicine.

N-Butanol Fraction of Wenxia Formula Extract Inhibits the Growth and Invasion of Non-Small Cell Lung Cancer by Down-Regulating Sp1-Mediated MMP2 Expression

“…Based on the theory of traditional Chinese Medicine, effective extraction and compatibility of traditional Chinese Medicine have attracted more and more attention from the medical profession (Bordoloi et al, 2016;Zhang et al, 2018;Mahmoudian-Sani and Asadi-Samani, 2020;Tian et al, 2020). The WXF is a traditional Chinese medicine formula consisted of multiple components, which focuses on dispelling cold, supplementing yangqi, activating blood circulation and clearing blood stasis.…”

Exploring new therapeutic potentials of curcumin against post-surgical adhesion bands

“…Animals in each model were randomly divided into 3 groups ( n = 6) as described below: (A) sham group with surgical incision but no adhesion, (B) positive control group with total surgical transection and adhesion receiving normal saline daily, (C) phytosomal curcumin group which is the same as group B except that rats were treated with 25 mg/kg/day curcumin orally [ 23 , 34 ] for either 7 or 21 days in peritoneal or tendon adhesion models, respectively. At the end of the experiments, rats were anesthetized, sacrificed, and tissue samples collected (rapid freezing by liquid nitrogen or stored in 10% formalin) for further assessments.…”

Nutraceuticals for the Treatment of IBD: Current Progress and Future Directions

“…Studies have shown that resveratrol, a common polyphenol in berries, seems to inhibit the occurrence of tumors by regulating signal transduction mechanisms and programmed cell death ( 73 ). It has been reported that some Chinese herbal medicines containing polyphenols and other active ingredients regulate apoptosis by regulating various signal transduction mechanisms, thus playing a role in preventing CAC ( 87 ).…”