Apoptosis Effects of Extract from Allium hookeri by AMPK/Akt/GSK-3β Signal Pathway in AGS Gastric Cancer Cells

Effects of Cirsium setidens extract on gene expression related to apoptosis induction and metastasis inhibition in human breast cancer

“…When phosphorylated p53 on the mitochondrial surface increases, the complex which is formed by Bcl-2, which promotes cell viability in the endogenous pathway, and Bax, a protein that liberates cytochrome c from mitochondria and induces apoptosis, is rearranged and apoptosis occurs through their antagonism (Jo et al, 2019). Therefore, the anticancer mechanism through apoptosis is the accumulation of phosphorylated p53 by the increase of AMPK in cancer cell, reducing Bcl-2 that inhibits apoptosis and increasing Bax that promotes apoptosis, resulting in loss of cell membrane potential and induces apoptosis through the destruction of the mitochondrial membrane and release of cytochrome c (Park et al, 2018;Cho et al, 2016).…”