Apoptosis-based therapy to treat pulmonary arterial hypertension

Suzuki, Yuichiro; Ibrahim, Yasmine; Shults, Nataliia V.

doi:10.29245/2572-9411/2016/2.1025

Cited by 14 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a macaque model of SIV/HIV associated PAH, Nef was detected in the endothelial layer of complex vascular lesions associated with the development of PAH [57], suggesting a role for Nef in the pathogenesis of HIV-PAH. While Nef lacks the cellular transduction properties of Tat, it is known to be secreted in extracellular vesicles [58] and is often detectable in the plasma of patients with receiving anti-retroviral therapy [59]. Furthermore, Nef is detected in the peripheral blood mononuclear cells of HIV-infected patients, the majority of which are uninfected [60].…”

Section: Hiv Nef and The Ddrmentioning

confidence: 99%

The DNA Damage Response and HIV-Associated Pulmonary Arterial Hypertension

Simenauer

Nozik‐Grayck

Cota‐Gomez

2020

IJMS

View full text Add to dashboard Cite

The HIV-infected population is at a dramatically increased risk of developing pulmonary arterial hypertension (PAH), a devastating and fatal cardiopulmonary disease that is rare amongst the general population. It is increasingly apparent that PAH is a disease with complex and heterogeneous cellular and molecular pathologies, and options for therapeutic intervention are limited, resulting in poor clinical outcomes for affected patients. A number of soluble HIV factors have been implicated in driving the cellular pathologies associated with PAH through perturbations of various signaling and regulatory networks of uninfected bystander cells in the pulmonary vasculature. While these mechanisms are likely numerous and multifaceted, the overlapping features of PAH cellular pathologies and the effects of viral factors on related cell types provide clues as to the potential mechanisms driving HIV-PAH etiology and progression. In this review, we discuss the link between the DNA damage response (DDR) signaling network, chronic HIV infection, and potential contributions to the development of pulmonary arterial hypertension in chronically HIV-infected individuals.

show abstract

Section: Hiv Nef and The Ddrmentioning

confidence: 99%

The DNA Damage Response and HIV-Associated Pulmonary Arterial Hypertension

Simenauer

Nozik‐Grayck

Cota‐Gomez

2020

IJMS

View full text Add to dashboard Cite

show abstract

Pulmonary Hypertension and Cancer: Etiology, Diagnosis, and Management

Ballout

Manshad

Okwuosa

2017

Curr Treat Options Cardio Med

View full text Add to dashboard Cite

Pulmonary hypertension is caused by cancer and its therapeutic agents including chemotherapy, radiotherapy, and even the targeted therapies. Ironically, some of the cancer therapies that cause one type of pulmonary hypertension (PH) could potentially be employed in the treatment of another PH type. Greater awareness on the role of cancer therapeutic agents in causing PH is required. Conversely, since PH is mostly incurable, the potential role of some of these cancer therapeutic agents in the cure of PH should be recognized. In short, the relationship between cancer, cancer therapy, and PH is an interesting one requiring further attention, education, and research.

show abstract

Dexrazoxane ameliorates doxorubicin-induced cardiotoxicity by inhibiting both apoptosis and necroptosis in cardiomyocytes

Ruan

Huang

et al. 2020

Biochemical and Biophysical Research Communications

View full text Add to dashboard Cite

Apoptosis-based therapy to treat pulmonary arterial hypertension

Cited by 14 publications

References 20 publications

The DNA Damage Response and HIV-Associated Pulmonary Arterial Hypertension

The DNA Damage Response and HIV-Associated Pulmonary Arterial Hypertension

Pulmonary Hypertension and Cancer: Etiology, Diagnosis, and Management

Dexrazoxane ameliorates doxorubicin-induced cardiotoxicity by inhibiting both apoptosis and necroptosis in cardiomyocytes

Contact Info

Product

Resources

About