“…It appears that this mechanism results from the ability of apoptotic cells to induce an upregulation of mitogen factors such as decapentaplegic and wingless mitogens (Pérez-Garijo et al, 2004;Ryoo et al, 2004). Apoptotic-dependent proliferation has also been reported or suggested in several organisms after injuries (Tseng et al, 2007;Donato-Santana et al, 2008;Mashanov et al, 2010;Pellettieri et al, 2010;Fok et al, 2020). After bisection of the cnidarian Hydra vulgaris, the apoptotic Frontiers in Cell and Developmental Biology frontiersin.org cells from the site of injury induce Wnt3 signaling in a caspasedependent manner, leading to the proliferation of adjacent stem cells, allowing tissue regeneration (Chera et al, 2009).…”