Apoptosis and interstitial fibrosis in remodeling of the myocardium in elderly patients with arterial hypertension

Nucleic acid-selective light-up fluorescent biosensors for ratiometric two-photon imaging of the viscosity of live cells and tissues

“…The character of each component in a cellular system and their complex biological functions and processes has attracted increasing attention, and therefore better understanding of the selective staining/imaging of specific cellular organelles is of paramount importance. 1 Since nucleic acid (NA) including DNA and RNA is the major source for storing, duplicating and transferring the genetic information in all eukaryotic cells, 2 , 3 design tools in NA imaging have become of great interest. 4 – 7 Commercial nuclear imaging agents 8 such as DAPI, Hoechst 33342 (DNA) and SYTO-Select (RNA) probe require ultraviolet light as excitation source, resulting in significant autofluorescence and extensive photon toxicity.…”

Fluorescence behavior of a unique two-photon fluorescent probe in aggregate and solution states and highly sensitive detection of RNA in water solution and living systems

“…Ribonucleic acid (RNA) is made of monomers known as nucleotides. 5 It plays a central role in converting genetic information from genes into the amino acid sequences of proteins. 6 RNA was discovered by Friedrich Miescher in 1869, 7 however, the RNAspecific dyes were first used to detect RNA in 1984.…”

The Role of Cardiomyocyte Apoptosis in the Pathogenesis of Neuroleptic Cardiomyopathy

“…One of the important elements of the pathogenesis of NCMP is a decrease in the number of cardiomyocytes (CMC). It is well known that the main determinant of myocardial dysfunction and heart failure (HF) in most pathological cardiac processes, including idiopathic dilated cardiomyopathy (DCMP), may be the loss of CMC ( Figure 1), which is one of the main triggers of cardiac remodeling [5][6][7][8][9][10][11][12][13]. Thus, according to the data of C. A. Beltrami with co-authors (1995), in the terminal stage of DCMP with the manifestation of decompensate chronic HF, the number of CMC in the muscle of left ventricle is reduced by 28% [8].…”