Apoptosis and cancer: mutations within caspase genes

Ghavami, Saeid; Hashemi, Mohammad; Ande, Sudharsana Rao; Yeganeh, Behzad; Xiao, Wenyan; Eshraghi, Mehdi; Bus, Christine; Kadkhoda, Kamran; Wiecheć, Emilia; Halayko, Andrew J.; Łos, Marek

doi:10.1136/jmg.2009.066944

Cited by 597 publications

(451 citation statements)

References 194 publications

(195 reference statements)

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“…Pro-caspase-8 is recruited to DISC by FADD, and dimerization or trimerization triggers pro-caspase-8 activation via reciprocal cleavage. Caspase-8, in turn, cleaves and activates caspase-3, -7, Bid, and also NF-kB [52,53]. Caspase-8 activation is regulated by cFLIP that is structurally homologous to caspase-8 but does not have caspase activity [54].…”

Section: Caspase Family Membersmentioning

confidence: 99%

Major apoptotic mechanisms and genes involved in apoptosis

et al. 2016

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As much as the cellular viability is important for the living organisms, the elimination of unnecessary or damaged cells has the opposite necessity for the maintenance of homeostasis in tissues, organs and the whole organism. Apoptosis, a type of cell death mechanism, is controlled by the interactions between several molecules and responsible for the elimination of unwanted cells from the body. Apoptosis can be triggered by intrinsically or extrinsically through death signals from the outside of the cell. Any abnormality in apoptosis process can cause various types of diseases from cancer to auto-immune diseases. Different gene families such as caspases, inhibitor of apoptosis proteins, B cell lymphoma (Bcl)-2 family of genes, tumor necrosis factor (TNF) receptor gene superfamily, or p53 gene are involved and/or collaborate in the process of apoptosis. In this review, we discuss the basic features of apoptosis and have focused on the gene families playing critical roles, activation/inactivation mechanisms, upstream/downstream effectors, and signaling pathways in apoptosis on the basis of cancer studies. In addition, novel apoptotic players such as miRNAs and sphingolipid family members in various kind of cancer are discussed.

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Section: Caspase Family Membersmentioning

confidence: 99%

Major apoptotic mechanisms and genes involved in apoptosis

et al. 2016

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“…Blebs are the progenitors of apoptotic bodies with small, nearly spherical cytoplasmic fragments encapsulated in cell membranes. Apoptotic bodies may contain functional organelles surrounded by intact plasma membranes (Elmore 2007;Ghavami et al 2009). Phosphatidylserine, a phospholipid embedded in the plasma membrane, is exposed on the outer side of apoptotic bodies.…”

Section: Introductionmentioning

confidence: 99%

“…Phosphatidylserine, a phospholipid embedded in the plasma membrane, is exposed on the outer side of apoptotic bodies. They act as ''eat me'' signals, thus attracting macrophages, and are efficiently phagocytosed (Elmore 2007;Ghavami et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Autophagy, Apoptosis, Mitoptosis and Necrosis: Interdependence Between Those Pathways and Effects on Cancer

Chaabane

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El-Gazzah

et al. 2012

Arch. Immunol. Ther. Exp.

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“…Conversely, the reduced expression or mutation of pro-apoptotic Bax/Bak or caspases has been reported in different cancers and correlated with poor clinical prognosis (Rampino et al, 1997;Shivapurkar et al, 2002;Fecker et al, 2006;Ghavami et al, 2009). Nevertheless, it is important to note that the abrogation of apoptotic pathways alone is unlikely to be sufficient to promote tumourigenesis since cancer often arises from a complex interplay of genetic aberrations and deregulated pathways.…”

Section: Apoptosis and Cancermentioning

confidence: 99%