Apomorphinwirkung auf das Kaninchen-EEG

Brucke, F; Petsche, H.; Sailer, S; Stumpf, Ch.

doi:10.1007/bf00245825

Cited by 6 publications

(2 citation statements)

References 6 publications

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“…It is possible that the phenomenon may be identical with chewing movements produced by apomorphine in rat (Du Toit and Christensen, 1948) and rabbit (Brucke, Petsche, Sailer, and Stumpf, 1957). Brucke et al (1957) have shown that there is a pronounced and long-lasting desynchronizing effect on precentral cortical electroencephalograph accompanying it in rabbits.…”

Section: Discussionmentioning

confidence: 89%

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Apomorphine‐induced Pecking in Pigeons

Bn¹,

Saxena²

1960

British Journal of Pharmacology and Chemotherapy

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Apomorphine produced persistent pecking in pigeons, the latent period, intensity and duration of which were related to the dose. The ED50 was estimated as 78.1 ±11.1 tig./kg. On chronic administration of apomorphine there was a significant decrease in latent period and weight which quickly returned to normal on stopping the drug. No conditioning and no tolerance were observed. The uncertain emetic effect of apomorphine in pigeons has been confirmed. Ten other centrally acting agents tested (caffeine, cocaine, 5-hydroxytryptamine, lysergic acid diethylamide, methamphetamine, morphine, nalorphine, pentylenetetrazol, strychnine, and yohimbine) failed to produce similar effects in pigeons.While engaged in a comparative evaluation of anti-emetic drugs in pigeons (Gujral, Saxena and Dhawan, 1956), an attempt was made to produce emesis by apomorphine. It was seen that instead of emesis the drug constantly produced persistent pecking. The birds pecked rapidly at the tin floor and wires in the side and ceiling of the cage as if pulling off particles from them and swallowing them. They ignored any grain that was put in the cage. The effect came on very quickly, persisted for 0.5 to 1 hr. and was so compulsive that in many cases the beak got injured and started bleeding. The pigeons were depressed for some time after the pecking had stopped. This type of fruitless pecking was not seen in normal pigeons. No reference could be found in the literature about this effect of apomorphine in pigeons. Our interest in the problem was revived by a report of similar effects of apomorphine in pigeons by Koster (1957 (regardless of sex) in large cages, and had free access to water and mixed grains. They were not used more than twice a week except when studying the effects of chronic administration. At the time of use they were placed separately in small wire mesh cages, and food and water were withdrawn. Experiments were carried out in a quiet room diffusely illuminated with daylight.The drugs were dissolved in distilled water or suspended in a 4% homogenized gum acacia solution. Whenever possible solutions or suspensions were prepared immediately before use. Each dose was tested in at least one batch of 10 birds. Intramuscular injections were made in the pectoral muscles, intravenous injections through alar veins, and oral administration by letting the suspension drop in the mouth from a tuberculin syringe.The birds were observed for at least 1 hr. after administration of drugs, and pecking was considered positive only if the bird pecked more than 10 times during this period. Active expulsion of crop contents was employed as the criterion for vomiting. The latent period was the period elapsing between the drug administration and the first act of pecking or vomiting respectively. The duration of pecking was the period during which at least 50% pigeons were pecking. Only an approximate estimate of the duration could, therefore, be made. The pecking was so rapid that it was difficult to count the exact number in each bird and an accurate ...

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Section: Discussionmentioning

confidence: 89%

“…Brucke et al (1957) have shown that there is a pronounced and long-lasting desynchronizing effect on precentral cortical electroencephalograph accompanying it in rabbits. A similar electroencephalographic pattern is produced by methamphetamine.…”

Section: Discussionmentioning

confidence: 97%

Apomorphine‐induced Pecking in Pigeons

Bn¹,

Saxena²

1960

British Journal of Pharmacology and Chemotherapy

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Conditioned effects of apomorphine are manifest in regional EEG of rats both in hippocampus and in striatum

Kropf

Kuschinsky

1993

Naunyn-Schmiedeberg's Arch Pharmacol

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Previously, in own studies, it was shown that stereotyped behaviour produced by apomorphine can be conditioned if the drug is repeatedly paired with defined environmental stimuli (conditioned stimuli, CS). Eventually, the presentation of CS alone produces stereotyped behaviour as conditioned response (CR). Furthermore, in electrocorticographic recordings it could be demonstrated that the characteristic pattern following acute apomorphine treatment, namely a selective increase in the power of the alpha-1 band, could be conditioned as well. In the present study, regional EEG was recorded in the striatum and in the hippocampus of freely moving rats. For conditioning, apomorphine (0.5 mg/kg s.c.) was paired with auditory and olfactory stimuli as CS for seven times, and on the eighth day the drug was substituted by the solvent in the presence of the CS. The effects were compared with those obtained in "pseudoconditioned" controls. Acute apomorphine administration led to an increase in power in the alpha-1 band (7.00-9.50 Hz), which effect was obvious in the hippocampus, above the cortex and in the striatum. After performing the conditioning procedure, these effects in regional EEG were found to be conditioned as well: as CR, activation in power in the alpha-1 band in hippocampus and striatum were manifest in the presence of the CS, but in absence of the drug. These effects occurred sporadically, but with a significantly higher frequency than in the pseudoconditioned controls. The results suggest that both the hippocampus and the striatum play important roles in classical conditioning of apomorphine effects which are primarily mediated by the striatum.

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Effect of cholinergic substances on bioelectrical activity of the limbic system

Il'yuchenok¹,

Bannikov²

1968

Bull Exp Biol Med

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Apomorphinwirkung auf das Kaninchen-EEG

Cited by 6 publications

References 6 publications

Apomorphine‐induced Pecking in Pigeons

Apomorphine‐induced Pecking in Pigeons

Conditioned effects of apomorphine are manifest in regional EEG of rats both in hippocampus and in striatum

Effect of cholinergic substances on bioelectrical activity of the limbic system

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