Apomorphine-induced hypoattention in rats and reversal of the choice performance impairment by aniracetam

Nakamura, Kazuo; Kurasawa, Mitsue; Tanaka, Yushiro

doi:10.1016/s0014-2999(97)01457-x

Cited by 25 publications

(16 citation statements)

References 61 publications

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“…In addition, CRT in well-trained rats is mostly unaffected by the locomotion change elicited by scopolamine and apomorphine (Nakamura et al 1998a(Nakamura et al , 1998b. These findings indicate that the DOI-elicited activation of 5-HT 2A receptors may disturb preferentially selective attention and then impair sustained attention and vigilance/arousal functions.…”

Section: Discussionmentioning

confidence: 76%

“…The compound was first characterized in animal models as a learning and memory enhancer, and thought to act through mechanisms such as positive modulation of cholinergic and glutamatergic nervous systems and an increase in synaptic efficacy and energy metabolism (Himori et al 1992;Martin and Haefely 1993;Pizzi et al 1993). We have reported recently that both scopolamine and apomorphine cause attentional deficits and low vigilance in rats that had mastered previously a two-lever choice reaction task, and that aniracetam reverses the induced performance impairments (Nakamura et al 1998a(Nakamura et al , 1998b. As yet, however, no studies have evaluated experimentally the interaction between aniracetam and serotonergic compounds on attention and vigilance.…”

Section: Kazuo Nakamura · Mitsue Kurasawamentioning

confidence: 99%

See 1 more Smart Citation

Serotonergic mechanisms involved in the attentional and vigilance task performance of rats and the palliative action of aniracetam

Nakamura¹,

Kurasawa²

2000

Naunyn-Schmiedeberg's Archives of Pharmacology

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Central serotonergic systems play an important role in regulating mood/emotion, cognition, sleep and wakefulness, appetite and locomotion and body temperature via multiple receptor subtypes. Among them, 5-HT1A and 5-HT2A/2C receptors have opposite effects with respect to certain functions. The aim of the present study was to compare the effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-HT1A receptor agonist, and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a selective 5-HT2A/2C receptor agonist, on the performance of middle-aged rats in a two-lever choice reaction task that assessed attention and vigilance functions. We also examined the effects of aniracetam, a cognition enhancer, and its major metabolites on the induced performance impairments. 8-OH-DPAT (0.3 mg/kg s.c.) reduced response speed and choice accuracy and increased response omission with a reduction of task-associated motor activity without inducing motor inability or motivational changes. These findings indicate a specific disturbance of attentional and vigilance processes. DOI caused similar impairments at the highest dose tested (3 mg/kg s.c.); at a lower dose (1 mg/kg s.c.), however, it selectively attenuated the response speed, suggesting a selective attention deficit. (-)-Alprenolol, a non-selective 5-HT1A receptor antagonist, and ritanserin, a preferential 5-HT2A receptor antagonist, blocked the 8-OH-DPAT- and DOI-induced performance impairments respectively. Aniracetam ameliorated all the performance deficits, and the metabolites N-anisoyl-GABA and 2-pyrrolidinone partially mimicked the aniracetam effect in the 8-OHDPAT-induced attentional and vigilance impairments. Nefiracetam, another cognition enhancer, improved only the 8-OH-DPAT-induced impairments. Each compound tested alone had no effect on task performance. These results indicate that both serotonergic regulations, possibly via presynaptic 5-HT1A receptors and more likely via postsynaptic 5-HT2A receptors, lead similarly to attention deficits.

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Section: Discussionmentioning

confidence: 76%

Section: Kazuo Nakamura · Mitsue Kurasawamentioning

confidence: 99%

Serotonergic mechanisms involved in the attentional and vigilance task performance of rats and the palliative action of aniracetam

Nakamura¹,

Kurasawa²

2000

Naunyn-Schmiedeberg's Archives of Pharmacology

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“…An increase in number of omissions resulting from dopaminergic manipulations has been documented in other cognitive tasks, including Go/No-Go tasks and the 5-choice serial reaction time test (Nakamura et al 1998; Czernecki et al 2002; Fletcher et al 2007; Verdejo-Garcia et al 2007). Increases in rate of omissions can result from an inability to perform the task due to motor deficits or because monkeys did not find the pellets delivered after correct responses to be reinforcing.…”

Section: Discussionmentioning

confidence: 92%

Effects of prior cocaine self-administration on cognitive performance in female cynomolgus monkeys

et al. 2015

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Rationale Cocaine use has been associated with cognitive impairments that may contribute to poor treatment outcomes. However, the degree to which these deficits extend into periods of abstinence has not been completely elucidated. Objectives This study tested whether prior experience self-administering cocaine affected acquisition of two cognitive tasks in 16 adult female cynomolgus monkeys. Seven monkeys had previously self-administered cocaine but had not had access to cocaine for two months at the start of this study. Methods After monkeys were trained to respond on a touchscreen, associative learning and behavioral flexibility were assessed using a stimulus discrimination (SD) and reversal (SDR) task from the CANTAB battery. Performance on this task was monitored over the subsequent three months. Additionally, working memory was assessed with a delayed match-to-sample (DMS) task. Results Cocaine-naïve monkeys required fewer total trials and made fewer errors and omissions before acquiring the SD and SDR tasks compared to monkeys who had previously self-administered cocaine; two monkeys in the latter group did not acquire the task. However, this cognitive impairment dissipated over several months of exposure to the task. The number of sessions for touch training and delays required to establish a performance-based curve on the DMS task did not differ between groups. Conclusion Results suggest that cocaine exposure can impair the ability to learn a novel task requiring behavioral inhibition and flexibility, even after an extended period of abstinence. However, this deficit did not extend to maintenance of the task or to acquisition of a working memory task.

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“…We recently found that aniracetam improved the hypoattention and reduced vigilance in middle-aged rats induced by apomorphine [Nakamura et al, 1998b]. Moreover, Himori and Mishima [1994] reported that aniracetam ameliorated excess lever-pressing in rats caused by methamphetamine.…”

Section: Discussionmentioning

confidence: 97%

Aniracetam attenuates the 5-HT2 receptor-mediated head-twitch response in rodents as a hallucination model

Tanaka¹,

Nakamura²,

Kurasawa³

1998

Drug Dev. Res.

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Apomorphine-induced hypoattention in rats and reversal of the choice performance impairment by aniracetam

Cited by 25 publications

References 61 publications

Serotonergic mechanisms involved in the attentional and vigilance task performance of rats and the palliative action of aniracetam

Serotonergic mechanisms involved in the attentional and vigilance task performance of rats and the palliative action of aniracetam

Effects of prior cocaine self-administration on cognitive performance in female cynomolgus monkeys

Aniracetam attenuates the 5-HT2 receptor-mediated head-twitch response in rodents as a hallucination model

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