Apomorphine has a therapeutic effect on neglect produced by unilateral dorsomedial prefrontal cortex lesions in rats

Corwin, James V.; Kanter, Steven L.; Watson, Robert; Heilman, Kenneth M.; Valenstein, Edward; Hashimoto, Atsutaka

doi:10.1016/0014-4886(86)90247-5

Cited by 104 publications

(58 citation statements)

References 35 publications

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“…Based on 'extensive cortico-cortical connections, ' Reep et al (1990) proposed that AGm is a multimodal association area with direct actions on motor systems, and accordingly serves a central role in directed spatial attention. Supporting this, lesions of AGm in rats produce contralateral neglect (failure to attend to meaningful stimuli presented contralaterally), comparable to deficits seen with lesions/damage to Brodmann's area 8 of primates (Crowne and Pathria 1982;Corwin et al 1986;King and Corwin 1993). We described a pattern of cortical projections to AGm largely consistent with that shown by Reep et al (1984Reep et al ( , 1990 as well as others (van Eden et al 1992;Conde et al 1995;Heidbreder and Groenewegen 2003), with some important differences.…”

Section: Medial Agranular Cortexsupporting

confidence: 83%

“…Reep and colleagues (Reep et al 1990, 1994, 2003Corwin and Reep 1998;Cheatwood et al 2005) have described an extended circuitry involving the medial PAp, AGm, Oc2M, VLO and the dorsocentral striatum that participates in directed spatial attention, and when disrupted, produces spatial neglect (Corwin et al 1986;Crowne et al 1986;King et al 1989;King and Corwin 1993;Van Vleet et al 2003).…”

Section: Anterior Cingulate Cortexmentioning

confidence: 99%

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Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat

2007

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The medial prefrontal cortex (mPFC) has been associated with diverse functions including attentional processes, visceromotor activity, decision making, goal directed behavior, and working memory. Using retrograde tracing techniques, we examined, compared, and contrasted afferent projections to the four divisions of the mPFC in the rat: the medial (frontal) agranular (AGm), anterior cingulate (AC), prelimbic (PL), and infralimbic (IL) cortices. Each division of the mPFC receives a unique set of afferent projections. There is a shift dorsoventrally along the mPFC from predominantly sensorimotor input to the dorsal mPFC (AGm and dorsal AC) to primarily 'limbic' input to the ventral mPFC (PL and IL). The AGm and dorsal AC receive afferent projections from widespread areas of the cortex (and associated thalamic nuclei) representing all sensory modalities. This information is presumably integrated at, and utilized by, the dorsal mPFC in goal directed actions. In contrast with the dorsal mPFC, the ventral mPFC receives significantly less cortical input overall and afferents from limbic as opposed to sensorimotor regions of cortex. The main sources of afferent projections to PL/IL are from the orbitomedial prefrontal, agranular insular, perirhinal and entorhinal cortices, the hippocampus, the claustrum, the medial basal forebrain, the basal nuclei of amygdala, the midline thalamus and monoaminergic nuclei of the brainstem. With a few exceptions, there are few projections from the hypothalamus to the dorsal or ventral mPFC. Accordingly, subcortical limbic information mainly reaches the mPFC via the midline thalamus and basal nuclei of amygdala. As discussed herein, based on patterns of afferent (as well as efferent) projections, PL is positioned to serve a direct role in cognitive functions homologous to dorsolateral PFC of primates, whereas IL appears to represent a visceromotor center homologous to the orbitomedial PFC of primates.

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Section: Medial Agranular Cortexsupporting

confidence: 83%

Section: Anterior Cingulate Cortexmentioning

confidence: 99%

Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat

2007

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“…This focus on DCS has come about because of its relationship to cortical area AGm. Unilateral lesions of AGm result in multimodal neglect of contralaterally presented stimuli, as do lesions of area PPC, with which AGm is strongly interconnected (Crowne and Pathria, 1982;Corwin et al, 1986;Crowne et al, 1986Crowne et al, , 1992Reep et al, 1987Reep et al, , 1990Reep et al, , 1994Corwin, 1990, 1993;Corwin and Reep, 1998). Some animals with these cortical lesions recover spontaneously over a period of several weeks (Vargo et al, 1988).…”

Section: Indexing Terms: Corticostriatal; Cerebral Cortex; Bda; Neuromentioning

confidence: 93%

“…Unilateral axon-sparing lesions of DCS result in severe neglect with no spontaneous recovery over 13 weeks (Van Vleet et al, 2000). These animals are unresponsive to the therapeutic effects of systemic administration of apomorphine (Van Vleet et al, 2003a), whereas this treatment results in transient recovery in rats with neglect produced by AGm lesions (Corwin et al, 1986). Furthermore, in rats with neglect resulting from AGm lesion, apomorphine infusion into DCS produces dramatic dose-dependent recovery from multimodal neglect (Van Vleet et al, 2003b).…”

Section: Indexing Terms: Corticostriatal; Cerebral Cortex; Bda; Neuromentioning

confidence: 96%

The associative striatum: Organization of cortical projections to the dorsocentral striatum in rats

Reep

Cheatwood

Corwin

2003

J of Comparative Neurology

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118

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The dorsocentral striatum (DCS) is the major site of input from medial agranular cortex (AGm) and has been implicated as an associative striatal area that is part of a cortical-subcortical circuit involved in multimodal spatial functions involving directed attention. Anterograde axonal tracing was used to investigate the spatial organization of corticostriatal projections to DCS. Injections of biotinylated dextran amine were made into several cortical areas known to project to DCS based on retrograde tracing data. These included areas AGm, lateral agranular cortex (AGl), orbital cortex, posterior parietal cortex (PPC), and visual association cortex. We discovered a previously undescribed geometry whereby the projection from AGm is prominent within DCS and the main corticostriatal projections from areas other than AGm are situated around the periphery of DCS: visual association cortex dorsomedially, PPC dorsally, AGl laterally, and orbital cortex ventrally. Each of these cortical projections is also represented by less dense aggregates of terminal labeling within DCS, organized as focal patches and more diffuse labeling. Because these cortical areas are linked by corticocortical connections, the present findings indicate that interconnected cortical areas have convergent terminal fields in the region of DCS. These findings suggest that DCS is a central associative region of the dorsal striatum characterized by a high degree of corticostriatal convergence.

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“…Pharmacological Treatment. In animals, bromocriptine improves circling behaviour in the unilateral 6-hydroxydopamine lesion model [199] and after frontal neglect [200]. In man, information on the neuropharmacological treatment of neglect is restricted to case reports or uncontrolled case series with conflicting results.…”

Section: Treatment Of Neglectmentioning

confidence: 99%

Recovery from Aphasia and Neglect

1999

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Apomorphine has a therapeutic effect on neglect produced by unilateral dorsomedial prefrontal cortex lesions in rats

Cited by 104 publications

References 35 publications

Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat

Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat

The associative striatum: Organization of cortical projections to the dorsocentral striatum in rats

Recovery from Aphasia and Neglect

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