Apolipoprotein M and the risk of unprovoked recurrent venous thromboembolism

Memon, Ashfaque A.; Sundquist, Jan; Zöller, Bengt; Wang, Xiao; Dahlbäck, Björn; Svensson, Peter; Sundquist, Kristina

doi:10.1016/j.thromres.2013.12.006

Cited by 8 publications

(20 citation statements)

References 32 publications

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“…FGG , being the precursor of fibrin, is an essential component of the hemostatic system [34]. In previous studies, we have shown that genetic variants and protein levels of ApoM were associated with the risk of VTE recurrence in a sex-specific manner [22, 26]. Similarly, PAI-1 polymorphism has been reported by us to be associated with an increased risk of VTE recurrence in the presence of FVL [35].…”

Section: Discussionmentioning

confidence: 93%

Risk prediction of recurrent venous thromboembolism: a multiple genetic risk model

Ahmad

Sundquist

Palmér

et al. 2018

J Thromb Thrombolysis

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A single genetic biomarker is unable to accurately predict the risk for venous thromboembolism (VTE) recurrence. We aimed to: (a) develop a multiple single nucleotide polymorphisms (SNPs) model to predict the risk of VTE recurrence and (b) validate a previously described genetic risk score (GRS) and compare its performance with the model developed in this study. Twenty-two SNPs, including established and putative SNPs associated with VTE risk, were genotyped in the Malmö thrombophilia study cohort (MATS; n = 1465, follow-up ~ 10 years) by using TaqMan PCR. Out of 22-SNPs, 12 had an association with the risk of VTE recurrence and were included for calculating GRSs. The risk of VTE recurrence was calculated by stratifying patients according to number of risk alleles. In 12-SNP GRS, patients with ≥ 7 risk alleles were associated with higher risk of VTE recurrence compared to patients having ≤ 6 risk alleles. In a simplified model (8-SNP GRS), the discriminative power of 8-SNP GRS was similar to that of 12-SNP GRS based on post-test probabilities (PP). Furthermore, 8-SNP GRS further improved the risk prediction of VTE recurrence in unprovoked VTE and male patients (PP% = 15.4 vs 8.3, 17.1 vs 7.2 and 19.0 vs 7.1 for high risk groups vs low risk groups in whole population, males and unprovoked VTE patients respectively). In addition, we also validated previously described 5-SNP GRS in our cohort and found that the 8-SNP GRS performed better than the 5-SNP GRS in terms of higher PP. Our results show that a multiple SNP GRS consisting of 8-SNPs may be an effective model for prediction of VTE recurrence, particularly in unprovoked VTE and male patients. Electronic supplementary material The online version of this article (10.1007/s11239-018-1762-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 93%

Risk prediction of recurrent venous thromboembolism: a multiple genetic risk model

Ahmad

Sundquist

Palmér

et al. 2018

J Thromb Thrombolysis

Self Cite

View full text Add to dashboard Cite

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“…For example pre-clinical animal studies suggest an anti-atherosclerotic role for ApoM [7]. Lower levels of ApoM have been observed in patients with critical limb ischemia [8] and were associated with higher risk of recurrent venous thromboembolism in men [9]. In the circulation, ApoM is predominantly associated with HDL [10] and affects the cholesterol balance of cells.…”

Section: Introductionmentioning

confidence: 99%

The association between apolipoprotein M and insulin resistance varies with country of birth

Memon

Bennet

Zöller

et al. 2014

Nutrition, Metabolism and Cardiovascular Diseases

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“…Nevertheless, role of ApoM has been reported in recurrent VTE by two studies previously; one reported that decreased ApoM plasma levels are associated with higher risk of VTE recurrence in male patients. In second study, genetic aberrations in ApoM were associated with the increased risk of VTE recurrence in male patients 28,29 . ApoM has also been studied for its role in other cardiovascular diseases including coronary artery disease where low levels of ApoM were associated with high risk of disease development 27,33 .…”

Section: Discussionmentioning

confidence: 92%

“…They also showed that ApoM plasma levels are better predictor of VTE recurrence than previously well-known predictive marker i.e. thrombophilia 29 . However, the role of ApoM plasma levels in primary VTE is unknown yet.…”

Section: Introductionmentioning

confidence: 88%

Evaluation of Expression Level of Apolipoprotein M as a Diagnostic Marker for Primary Venous Thromboembolism

Ahmad

Sundquist

Zöller

et al. 2017

Clin Appl Thromb Hemost

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Recently, decreased levels of apolipoprotein M (ApoM) were shown to be associated with higher risk of recurrent venous thromboembolism (VTE) in male patients. However, the role of ApoM in primary VTE is unknown. We aimed in our study to analyze the plasma levels of ApoM in patients with VTE in order to evaluate the diagnostic importance of ApoM in primary VTE. A total of 357 patients with suspected first episode of VTE were recruited prospectively in the SCORE study. Plasma samples from 307 patients were available for quantifying the plasma levels of ApoM in patients with VTE using sandwich enzyme-linked immunosorbent assay method. Among the whole population, plasma levels (mean [standard deviation]) of ApoM were not significantly different between patients with VTE (0.72 [0.20]) and non-VTE patients (0.72 [0.16]), P = .99. Similarly, in regression analyses, no significant association of ApoM plasma levels with the risk of VTE was found on univariate (odds ratio [OR] =1.0, 95% confidence interval [CI] 0.21-4.84, P = .99) and multivariate analysis (OR = 1.25, 95% CI = 0.19-8.34, P = .819) after adjusting for age, body mass index, and smoking. Moreover, results did not differ significantly after stratification of data according to sex ( P > .05). In this study, our results do not suggest a diagnostic role for ApoM plasma levels in patients with primary VTE. Moreover, the current study suggests that role of ApoM as a risk factor may differ for primary VTE and recurrent VTE in male patients.

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Apolipoprotein M and the risk of unprovoked recurrent venous thromboembolism

Cited by 8 publications

References 32 publications

Risk prediction of recurrent venous thromboembolism: a multiple genetic risk model

Risk prediction of recurrent venous thromboembolism: a multiple genetic risk model

The association between apolipoprotein M and insulin resistance varies with country of birth

Evaluation of Expression Level of Apolipoprotein M as a Diagnostic Marker for Primary Venous Thromboembolism

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