Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling

Wang, Hui; Zhou, Honghang; Ren, Runling; Du, Shaoxia; Guo, Zhongkui; Shen, Xiaohong

doi:10.1016/j.hbpd.2022.09.010

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…This signaling cascade entails the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), which subsequently activate the transcription factor known as cAMP response element-binding protein (CREB). Upon activation, CREB initiates the expression of various target genes, including Bcl-2, a protein well-known for its anti-apoptotic properties [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

An anthocyanin-rich extract from Zea mays L. var. ceratina alleviates neuronal cell death caused by hydrogen peroxide-induced cytotoxicity in SH-SY5Y cells

Mairuae,

Palachai,

Noisa

2024

BMC Complement Med Ther

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The incidence of dementia is rising, with neuronal cell death from oxidative stress and apoptosis recognized as a significant contributor to its development. However, effective strategies to combat this condition are lacking, necessitating further investigation. This study aimed to assess the potential of an anthocyanin-rich extract from Zea mays L. var. ceratina (AZC) in alleviating neuronal cell death.Neurotoxicity was induced in SH-SY5Y cells using hydrogen peroxide (H2O2) at a concentration of 200 µM. Cells were pretreated with varying doses (31.25 and 62.5 µg/mL) of AZC. Cell viability was assessed using the MTT assay, and molecular mechanisms including reactive oxygen species (ROS) levels, antioxidant enzyme activities (catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px)), malondialdehyde (MDA) levels for oxidative stress, and the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), cAMP response element-binding protein (CREB), and apoptotic factors (B-cell lymphoma 2 (Bcl-2), caspase 3) were explored.Results showed that AZC significantly improved cell viability, reduced ROS production and MDA levels, and downregulated caspase 3 expression. It enhanced CAT, SOD, and GSH-Px activities, activated ERK1/2 and CREB, and upregulated Bcl-2 expression. These findings support the neuroprotective effects of AZC, suggesting it activates ERK1/2, leading to CREB activation and subsequent upregulation of Bcl-2 expression while suppressing caspase 3. AZC may mitigate neuronal cell death by reducing ROS levels through enhanced scavenging enzyme activities.In conclusion, this study underscores the potential of AZC as a neuroprotective agent against neuronal cell death. However, further investigations including toxicity assessments, in vivo studies, and clinical trials are necessary to validate its benefits in neuroprotection.

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Section: Discussionmentioning

confidence: 99%

An anthocyanin-rich extract from Zea mays L. var. ceratina alleviates neuronal cell death caused by hydrogen peroxide-induced cytotoxicity in SH-SY5Y cells

Mairuae,

Palachai,

Noisa

2024

BMC Complement Med Ther

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“…Furthermore, APOE expression was found to be higher in pancreatic cancer tissue than in normal pancreatic tissue, and that elevated APOE levels are linked to worse outcomes for pancreatic cancer patients [128,129]. In addition, APOE2 has been found to aid pancreatic cancer cells in avoiding mitochondrial apoptosis by regulating the mitochondrial localization and expression of BCL-2 through the activation of the ERK1/2/CREB signaling cascade [130]. A study found that pancreatic cancer cell proliferation is associated with increased expression of APOE2-LRP8, a ligandreceptor pair that promotes tumor progression.…”

Section: Apolipoproteins In Pancreatic Cancermentioning

confidence: 99%

The Role of Apolipoproteins in the Commonest Cancers: A Review

Darwish,

Al-Hail,

Mohamed

et al. 2023

Cancers

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Apolipoproteins (APOs) are vital structural components of plasma lipoproteins that are involved in lipid metabolism and transport. Recent studies have reported an association between apolipoprotein dysregulation and the onset of a variety of human cancers; however, the role of certain APOs in cancer development remains unknown. Based on recent work, we hypothesize that APOs might be involved in the onset of cancer, with a focus on the most common cancers, including breast, lung, gynecological, colorectal, thyroid, gastric, pancreatic, hepatic, and prostate cancers. This review will focus on the evidence supporting this hypothesis, the mechanisms linking APOs to the onset of cancer, and the potential clinical relevance of its various inhibitors.

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Improvement of hepatic fibrosis by leukotriene inhibition in cholestatic rats

Elswefy

Hassanen

2009

Annals of Hepatology

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Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling

Cited by 3 publications

References 40 publications

An anthocyanin-rich extract from Zea mays L. var. ceratina alleviates neuronal cell death caused by hydrogen peroxide-induced cytotoxicity in SH-SY5Y cells

An anthocyanin-rich extract from Zea mays L. var. ceratina alleviates neuronal cell death caused by hydrogen peroxide-induced cytotoxicity in SH-SY5Y cells

The Role of Apolipoproteins in the Commonest Cancers: A Review

Improvement of hepatic fibrosis by leukotriene inhibition in cholestatic rats

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