Apolipoprotein E polymorphisms increase the risk of post-stroke depression

Xue-bin, LI; Wang, Jie; Xu, Anding; Huang, Jianmin; Li, Meng; Rui-ya, Huang; Wang, Junli

doi:10.4103/1673-5374.194748

Cited by 23 publications

(14 citation statements)

References 33 publications

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“…47 One small-scale study reported a possible link between the APOE-ε4 allele and depression. 17 Interestingly, hypercortisolemia, blunted cortisol awakening response, 73 and APOE polymorphisms 74 increase the risk of post-stroke depression.…”

Section: Discussionmentioning

confidence: 99%

Depression after Subarachnoid Hemorrhage: A Systematic Review

et al. 2020

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Background and Purpose Depression is common and debilitating illness accompanying many neurological disorders including non-traumatic subarachnoid hemorrhage (SAH). The aim of this systematic review was to identify and critically appraise all published studies that have reported the frequency, severity and time course of depression after SAH, the factors associated with its development and the impact of depression on patients’ quality of life after SAH.Methods The PubMed database was searched for studies published in English that recruited at least 40 patients (>18 years old) after SAH who were also diagnosed with depression.Results Altogether 55 studies covering 6,327 patients met study entry criteria. The frequency of depression ranged from 0% to 61.7%, with a weighted proportion of 28.1%. Depression remained common even several years after the index SAH. Depression after SAH was associated with female sex, premorbid depression, anxiety, substance use disorders or any psychiatric disorders, and coping styles. Comorbid cognitive impairment, fatigue, and physical disability also increased the risk of depression. Aneurysmal SAH and infarction may be related to depression as well. Depression reduces the quality of life and life satisfaction in patients after SAH.Conclusions Depression is common after SAH and seems to persist. Further research is needed to clarify its time course and identify the neuroendocrine and neurochemical factors and brain circuits associated with the development of post-SAH depression. Randomized controlled treatment trials targeting SAH-related depression are warranted.

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Section: Discussionmentioning

confidence: 99%

Depression after Subarachnoid Hemorrhage: A Systematic Review

et al. 2020

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“…It was previously shown that rs429358 was associated with the increased serum total cholesterol level and depression severity, and the authors hypothesized APOE variants to be detrimental to recovery of nerve function after stroke. 21 By performing a GWAS, corrected for BMI, baseline age, and population structure, we confirmed that APOE variants were associated with total cholesterol, with top hit rs7412, p = 3.4e-47 (figure e-5). Functional analyses (table e-6) showed an enrichment of GO terms related to regulation of cholesterol biosynthetic process, lipoprotein particle receptor binding, protein-lipid complex binding, and low-density lipoprotein particle remodeling.…”

Section: Resultsmentioning

confidence: 55%

Matrix metalloproteinase-degraded type I collagen is associated with APOE/TOMM40 variants and preclinical dementia

et al. 2020

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ObjectiveDysregulation of type I collagen metabolism has a great impact on human health. We have previously seen that matrix metalloproteinase–degraded type I collagen (C1M) is associated with early death and age-related pathologies. To dissect the biological impact of type I collagen dysregulation, we have performed a genome-wide screening of the genetic factors related to type I collagen turnover.MethodsPatient registry data and genotypes have been collected for a total of 4,981 Danish postmenopausal women. Genome-wide association with serum levels of C1M was assessed and phenotype-genotype association analysis performed.ResultsTwenty-two genome-wide significant variants associated with C1M were identified in the APOE-C1/TOMM40 gene cluster. The APOE-C1/TOMM40 gene cluster is associated with hyperlipidemia and cognitive disorders, and we further found that C1M levels correlated with tau degradation markers and were decreased in women with preclinical cognitive impairment.ConclusionsOur study provides elements for better understanding the role of the collagen metabolism in the onset of cognitive impairment.

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“…It is an apoprotein which is known to regulate lipid homeostasis and also plays a critical role in neuronal repair [215]. A study of Chinese patients with PSD has shown that the presence of APOE polymorphism is linked to an increased risk of PSD with an odds ratio of 3.17 for the rs429358-TC allele and 11.24 for the rs429358-CC allele [216].…”

Section: Inflammation-related Genetic Polymorphisms Associated With Psdmentioning

confidence: 99%

Post Stroke Depression to be Expected

Wijeratne¹,

Sales²

2021

Preprint

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Ischemic Stroke precedes depression . Post Stroke Depression (PSD) is a major driver for poor recovery, negative quality of life, poor rehabilitation outcomes and poor functional ability. This systematic reviews confirmed the post stroke depression as the norm as complex ischemic cascade involve the bioenergetic failure, deranged iron homeostasis ( calcium influx, Na influx, potassium efflux etc) excitotoxicity, acidotoxicity,disruption of the blood brain barrier, cytokine mediated cytotoxicity, reactive oxygen mediated toxicity , activation of cyclooxygenase pathway and generation of toxic products, infiltration of immune mediated cells resulting the cell death and deranged neuronal networks in mood related brain regions. This review focus on the pathobiology of stroke in the context and make the argument that PSD is the norm after a stroke rather than the exception.

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Apolipoprotein E polymorphisms increase the risk of post-stroke depression

Cited by 23 publications

References 33 publications

Depression after Subarachnoid Hemorrhage: A Systematic Review

Depression after Subarachnoid Hemorrhage: A Systematic Review

Matrix metalloproteinase-degraded type I collagen is associated with APOE/TOMM40 variants and preclinical dementia

Post Stroke Depression to be Expected

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