Apolipoprotein E polymorphism, life stress and self-reported health among older adults

Zhang, F; Lewis, Megan A.; Yang, Guoyi; Iriondo-Perez, Jeniffer; Yi, Zhengfang; Liu, J

doi:10.1136/jech.2007.063917

Cited by 17 publications

(16 citation statements)

References 77 publications

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“…The APOE genotypes and alleles in our study population were similar to those reported in previous studies from Japan and Taiwan. 25,26 Although the e3/e3 genotype and e3 allele are common in both Asian and Caucasian populations, a significant difference in the proportion of e4 alleles has been noted. 17,[25][26][27][28] The e4 allele was found in only 5.7% of our control subjects and has been reported in 5%-10% in other Asian populations, compared with a prevalence of 15%-18% in Caucasians (Table 5).…”

Section: Discussionmentioning

confidence: 98%

“…25,26 Although the e3/e3 genotype and e3 allele are common in both Asian and Caucasian populations, a significant difference in the proportion of e4 alleles has been noted. 17,[25][26][27][28] The e4 allele was found in only 5.7% of our control subjects and has been reported in 5%-10% in other Asian populations, compared with a prevalence of 15%-18% in Caucasians (Table 5). 17,[25][26][27][28] Because the APOE e4 allele is strongly associated with extracranial carotid disease, the lower frequency of the e4 allele in Asians may help explain the low prevalence of this disease in this population.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Association between Genetic Polymorphisms and Sites of Cervicocerebral Artery Atherosclerosis

Chutinet

Suwanwela

Snabboon

et al. 2012

Journal of Stroke and Cerebrovascular Diseases

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Association between Genetic Polymorphisms and Sites of Cervicocerebral Artery Atherosclerosis

Chutinet

Suwanwela

Snabboon

et al. 2012

Journal of Stroke and Cerebrovascular Diseases

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“…BRN not working on ward and BRN working on ward . Five control variables were recoded into categorical variables to avoid sparse cells and for the ease of interpretation [42]. Ward size was recoded into 4 categories, i.e.…”

Section: Methodsmentioning

confidence: 99%

Relationship between the presence of baccalaureate-educated RNs and quality of care: a cross-sectional study in Dutch long-term care facilities

Backhaus

Rossum

Verbeek

et al. 2017

BMC Health Serv Res

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BackgroundRecent evidence suggests that an increase in baccalaureate-educated registered nurses (BRNs) leads to better quality of care in hospitals. For geriatric long-term care facilities such as nursing homes, this relationship is less clear. Most studies assessing the relationship between nurse staffing and quality of care in long-term care facilities are US-based, and only a few have focused on the unique contribution of registered nurses. In this study, we focus on BRNs, as they are expected to serve as role models and change agents, while little is known about their unique contribution to quality of care in long-term care facilities.MethodsWe conducted a cross-sectional study among 282 wards and 6,145 residents from 95 Dutch long-term care facilities. The relationship between the presence of BRNs in wards and quality of care was assessed, controlling for background characteristics, i.e. ward size, and residents’ age, gender, length of stay, comorbidities, and care dependency status. Multilevel logistic regression analyses, using a generalized estimating equation approach, were performed.Results57% of the wards employed BRNs. In these wards, the BRNs delivered on average 4.8 min of care per resident per day. Among residents living in somatic wards that employed BRNs, the probability of experiencing a fall (odds ratio 1.44; 95% CI 1.06-1.96) and receiving antipsychotic drugs (odds ratio 2.15; 95% CI 1.66-2.78) was higher, whereas the probability of having an indwelling urinary catheter was lower (odds ratio 0.70; 95% CI 0.53-0.91). Among residents living in psychogeriatric wards that employed BRNs, the probability of experiencing a medication incident was lower (odds ratio 0.68; 95% CI 0.49-0.95). For residents from both ward types, the probability of suffering from nosocomial pressure ulcers did not significantly differ for residents in wards employing BRNs.ConclusionsIn wards that employed BRNs, their mean amount of time spent per resident was low, while quality of care on most wards was acceptable. No consistent evidence was found for a relationship between the presence of BRNs in wards and quality of care outcomes, controlling for background characteristics. Future studies should consider the mediating and moderating role of staffing-related work processes and ward environment characteristics on quality of care.

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“…The analyses of APOE genotype used the polymerase chain reaction amplification refractory mutation system (PCR-ARMS) and polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) [25]. APOE4 was categorized in terms of whether or not participants carried at least one copy of the E4 allele (yes/no/unknown) [35]. …”

Section: Methodsmentioning

confidence: 99%

“…Exercise was divided into three categories: less than once per week, two to five times per week, and more than six times per week [35]. The other covariates in this study consisted of the individual demographic characteristics of the participants (gender and ethnicity) [37] and whether the individual had depressive symptomatology [38, 39].…”

Section: Methodsmentioning

confidence: 99%

General cognitive status among Baby boomers and pre-boomers in Taiwan: the interplay between mid-life socioeconomic status and city residence

Chiao¹

2017

BMC Geriatr

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BackgroundThis study seeks to assess the interaction between mid-life socioeconomic status (SES) and city residence on the cognitive status of Baby Boomers and pre-Boomers in Taiwan, a non-Western society with a distinct cultural and family context, taking apolipoprotein E (APOE) gene polymophism and life stressors into consideration.MethodsThe data used was from the Social Environment and Biomarkers of Aging Study (SEBAS) collected in Taiwan during 2006, this involved 1245 individuals from 23 communities and used multilevel regression. General cognitive status was assessed by ten questions via personal interviews. The questions were part of the Short Portable Mental Status Questionnaire, a 10-item free-recall and immediate recall test. Mid-life SES was defined by education and major mid-life occupation of the participant and/or their partner.ResultsMid-life SES was positively associated with cognitive status among both Baby Boomers and pre-Boomers, even after adjusting for APOE polymorphism and stressor covariates. For Baby Boomers, city residents were more likely than town residents to show better cognition (β = 1.47, p < 0.01) and an interaction effect between mid-life SES and city residence was observed (β = −2.12, p < 0.01). While both the Baby Boomer and pre-Boomer cohorts who lived with a partner were reported better cognition, the effects of depressive symptoms and ethnicity differed by cohort.ConclusionsHaving a high level of mid-life SES and living with a partner are associated with better cognition for both cohort groups. An interplay effect between mid-life SES and place of residence on cognition was only found for Baby Boomers. On the other hand, being psychologically depressed was associated with poorer cognition among pre-Boomers. These results underscore the specific roles of mid-life SES, city residence, and life stressors with regard to the cognitive status of Baby Boomers and pre-Boomers in Taiwan.

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Apolipoprotein E polymorphism, life stress and self-reported health among older adults

Cited by 17 publications

References 77 publications

Association between Genetic Polymorphisms and Sites of Cervicocerebral Artery Atherosclerosis

Association between Genetic Polymorphisms and Sites of Cervicocerebral Artery Atherosclerosis

Relationship between the presence of baccalaureate-educated RNs and quality of care: a cross-sectional study in Dutch long-term care facilities

General cognitive status among Baby boomers and pre-boomers in Taiwan: the interplay between mid-life socioeconomic status and city residence

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