Current Opinion in Lipidology 2016 DOI: 10.1097/mol.0000000000000383 View full text
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Fan Liao, Hyejin Yoon, Jungsu Kim

Abstract: Purpose of reviewAPOE4 genotype is the strongest genetic risk factor for Alzheimer's disease. Prevailing evidence suggests that amyloid β plays a critical role in Alzheimer's disease. The objective of this article is to review the recent findings about the metabolism of apolipoprotein E (ApoE) and amyloid β and other possible mechanisms by which ApoE contributes to the pathogenesis of Alzheimer's disease.Recent findingsApoE isoforms have differential effects on amyloid β metabolism. Recent studies demonstrated…

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