Apolipoprotein E in Alzheimer’s disease trajectories and the next-generation clinical care pathway

Narasimhan, Sneha; Holtzman, David M.; Apostolova, Liana G.; Cruchaga, Carlos; Masters, Colin L.; Hardy, John; Villemagne, Victor L.; Bell, Joanne; Cho, Min; Hampel, Harald

doi:10.1038/s41593-024-01669-5

Nat Neurosci

2024

DOI: 10.1038/s41593-024-01669-5

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Apolipoprotein E in Alzheimer’s disease trajectories and the next-generation clinical care pathway

Sneha Narasimhan,

David M. Holtzman,

Liana G. Apostolova

et al.

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Cited by 2 publications

References 139 publications

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Alzheimer’s disease: from early pathogenesis to novel therapeutic approaches

Prajapati,

Pathak,

Samaiya

2024

Metab Brain Dis

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Alzheimer’s disease: from early pathogenesis to novel therapeutic approaches

Prajapati,

Pathak,

Samaiya

2024

Metab Brain Dis

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Sleep Disordered Breathing and Neurocognitive Disorders

Ogbu,

Menon,

Chahil

et al. 2024

JCM

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Sleep-disordered breathing (SDB), which includes conditions such as obstructive sleep apnea (OSA) and central sleep apnea (CSA), is an independent risk factor for cerebral small vessel disease (CSVD), stroke, heart failure, arrhythmias, and other cardiovascular disorders. The influence of OSA on brain structure and cognitive function has become an essential focus in the heart-brain axis, given its potential role in developing neurocognitive abnormalities. In this review, we found that OSA plays a significant role in the cardio-neural pathway that leads to the development of cerebral small vessel disease and neurocognitive decline. Although data is still limited on this topic, understanding the critical role of OSA in the heart-brain axis could lead to the utilization of imaging modalities to simultaneously identify early signs of pathology in both organ systems based on the known OSA-driven pathological pathways that result in a disease state in both the cardiovascular and cerebrovascular systems. This narrative review aims to summarize the current link between OSA and neurocognitive disorders, cardio-neural pathophysiology, and the treatment options available for patients with OSA-related neurocognitive disorders.

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Apolipoprotein E in Alzheimer’s disease trajectories and the next-generation clinical care pathway

Cited by 2 publications

References 139 publications

Alzheimer’s disease: from early pathogenesis to novel therapeutic approaches

Alzheimer’s disease: from early pathogenesis to novel therapeutic approaches

Sleep Disordered Breathing and Neurocognitive Disorders

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