Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men

Shinomiya, Sachiko; Sasaki, Jun; Kiyohara, Chikako; Tsuji, Emiko; Inoue, Hisako; Marugame, Tomomi; Handa, Koichi; Hayabuchi, Hitomi; Hamada, Hatsuyuki; Eguchi, Hironobu; Fukushima, Yoshitaka; Kono, Suminori

doi:10.1016/s0304-3835(00)00724-2

Cited by 28 publications

(41 citation statements)

References 38 publications

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“…Epidemiological data indicate that the frequency of the 3 allele is higher in Japanese and Chinese than in Caucasians, while the frequency of the 4 allele is lower in Asians than Caucasians 3,16) . Our data indicate that the frequency of the 3 allele is quite consistent with previous reports in Japanese 8,11,16,17) , and is slightly higher than that of Icelandic and Hungarian populations and much higher than that in the Finnish population 15) . Our study confirmed that the 4 allele is associated with higher, and the 2 allele is associated with lower, LDL cholesterol levels.…”

Section: Discussionsupporting

confidence: 92%

“…An elevated homocysteine level is associated with coronary heart disease and the C677T polymorphism in the MTHFR gene results in reduced MTHFR enzyme activity and reduced methylation of homocysteine to methioneine resulting in mild hyperhomocysteinemia 10) . Although several studies have examined the incidence of APOE and MTH-FR polymorphisms 8,11) , these has been no large-scale study to determine the incidence of APOE and MTH-FR polymorphisms and their association with lipoprotein profiles and homocysteine levels in the general Japanese population. In 2000, we conducted a lipid survey in the Japanese population, 12,839 people all over the country.…”

Section: Introductionmentioning

confidence: 99%

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Polymorphisms of Apolipoprotein E and Methylenetetrahydrofolate Reductase in the Japanese Population

Arai

Yamamoto

Matsuzawa

et al. 2007

JAT

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Aim:The aim of this study is to analyze the effect of apolipoprotein E (apo E) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms on serum lipid and homocysteine levels in the general Japanese population. Methods: We analyzed the polymorphisms in individuals randomly selected from among participants of Serum Lipid Survey 2000. Results: The frequency of the 2, 3, and 4 alleles of APOE was 4.2, 85.3, and 10.5%, respectively. Individuals with the genotype 4/ 4 had the highest total and low-density lipoprotein (LDL) cholesterol levels, while those with 2/ 2 had the lowest. Individuals with the 2/ 2 and 2/ 4 genotypes had higher remnant-like particles (RLP)-cholesterol levels than those with 2 3, 3 3, and 3 4. There was a trend for individuals with the 2/ 4 and 2/ 2 genotypes to have higher triglyceride levels, although the difference was not significant. The presence of the T allele in a MTHFR polymorphism (C667T) was associated with higher homocysteine levels, which is more prominent in men than in women. Conclusion: Thus in our large-scale analysis we have shown that RLP-cholesterol is better associated with APOE genotype than triglyceride and the effect of the T allele on MTHFR polymorphism (C667T) homocysteine levels is more prominent in men than in women among Japanese.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Polymorphisms of Apolipoprotein E and Methylenetetrahydrofolate Reductase in the Japanese Population

Arai

Yamamoto

Matsuzawa

et al. 2007

JAT

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“…While it is clear that APO E plays an essential role in cellular repair processes [1, 42], few studies have evaluated its role in terms of cancer risk in general [41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57], and cancer of the breast in particular [44, 51, 53]. From clinical studies, however, one can infer its influence on cellular homeostasis [1, 42], repair at the cellular level [1]and on carcinogenesis [41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57]. APO E, for instance, has been shown to inhibit the growth of several tumour cell lines, including breast cancer cells, melanoma cells, and Kaposi’s sarcoma cells [1, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57].…”

Section: Cellular Repair and Protective Mechanismsmentioning

confidence: 99%

Apolipoprotein E and the Risk of Breast Cancer in African-American and Non-Hispanic White Women

2004

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The apolipoprotein genetic polymorphism (APO E) is part of a broader paradigm, highlighting the role of gene-environment interactions as risk factors for human diseases such as cardiovascular disease, Alzheimer’s disease, dementia, atherosclerosis, multiple sclerosis, peripheral artery disease, diabetes, stroke, and most recently, cancer. APO E, a normal constituent of very-low-density lipoproteins and high-density lipoproteins, is involved in many functions, including lipid metabolism, cholesterol transport, tissue repair, immune response and regulation, as well as cell growth and differentiation. The location, frequency and functional effects of this gene have been reviewed elsewhere in terms of cardiovascular disease, Alzheimer’s disease, neuromuscular disease, multiple sclerosis, stroke and diabetes. However, while the majority of studies have examined the significance of APO E as a molecular marker for a variety of diseases in multiethnic populations, few evaluate its role as a putative marker of cancer susceptibility. Fewer explore the importance of APO E on the risk of breast cancer, although some report an association. None have been designed to study its relevance as a marker of breast cancer risk in multiethnic populations. The purpose of this review was to evaluate the association between APO E and the risk for breast cancer in non-Hispanic white and African-American women.

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“…Souza et al www.bjournal.com.br metabolism of cholesterol also influence susceptibility to cancer. Hence, apolipoprotein E (apo E), which is a multifunctional protein with a role in the transport and metabolism of lipids (6), has also been considered in the etiology of CRC (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

“…The APOE*4 allele seems to exert a protective effect in populations with high exposure to environmental factors predisposing to colon carcinoma (7,8), considering the hypothesis that ε4/ε4 homozygosity at the APOE locus was just found among controls, although this effect has not been confirmed in low-risk populations (7)(8)(9). Ethnic diversity, distinct eating habits and environmental factors characterize populations, whose profile should be investigated in association with determined genetic variants representing risk factors for this disease.…”

Section: Introductionmentioning

confidence: 99%

Association between apolipoprotein E genotype, serum lipids, and colorectal cancer in Brazilian individuals

Souza

Nakazone

Pinhel

et al. 2009

Braz J Med Biol Res

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We evaluated genetic variants of apolipoprotein E (APOE HhaI) and their association with serum lipids in colorectal cancer (CRC), together with eating habits and personal history. Eight-seven adults with CRC and 73 controls were studied. APOE*2 (rs7412) and APOE*4 (rs429358) were identified by polymerase chain reaction-restriction fragment length polymorphism. APOE gene polymorphisms were similar in both groups, but the ε4/ε4 genotype (6%) was present only in controls. The patients had reduced levels (mean ± SD) of total cholesterol and low-density lipoprotein cholesterol fraction (180.4 ± 49.5 and 116.1 ± 43.1 mg/dL, respectively) compared to controls (204.2 ± 55.6, P = 0.135 and 134.7 ± 50.8 mg/dL; P = 0.330, respectively) indicating that they were not statistically significant after the Bonferroni correction. The APOE*4 allele was associated with lower levels of total cholesterol, low-and high-density lipoprotein cholesterol fraction and increased levels of very low-density lipoprotein cholesterol fraction and triglycerides only among patients (P = 0.014). There was a positive correlation between the altered lipid profile and increased body mass indexes in both groups (P < 0.010). Moreover, a higher rate of hypertension and overweight was observed in controls (P < 0.002). In conclusion, the presence of the ε4/ε4 genotype only in controls may be due to a protective effect against CRC. Lower lipid profile values among patients, even those on lipid-rich diets associated with the APOE*4 allele, suggest alterations in the lipid synthesis and metabolism pathways in CRC.

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Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men

Cited by 28 publications

References 38 publications

Polymorphisms of Apolipoprotein E and Methylenetetrahydrofolate Reductase in the Japanese Population

Polymorphisms of Apolipoprotein E and Methylenetetrahydrofolate Reductase in the Japanese Population

Apolipoprotein E and the Risk of Breast Cancer in African-American and Non-Hispanic White Women

Association between apolipoprotein E genotype, serum lipids, and colorectal cancer in Brazilian individuals

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