Apolipoprotein D subcellular distribution pattern in neuronal cells during oxidative stress

Martínez‐Pinilla, Eva; Navarro, Ana; Ordóñez, Cristina; Valle, Eva del; Tolivia, Jorge

doi:10.1016/j.acthis.2015.04.003

Cited by 8 publications

(8 citation statements)

References 51 publications

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“…Reference Collection 15 (Bouma et al, 1988;Boyles et al, 1990a,b;Escribano et al, 1995;Navarro et al, 1998Navarro et al, , 2004Navarro et al, , 2008Navarro et al, , 2010aSuresh et al, 1998;Franz et al, 1999;Ong et al, 1999Ong et al, , 2002Kalman et al, 2000;Belloir et al, 2001;Hu et al, 2001;Thomas et al, 2001b;del Valle et al, 2003;Khan et al, 2003;Desai et al, 2005;Hildebrand et al, 2005;Del Signore et al, 2006;Ordoñez et al, 2006;Chen et al, 2007Chen et al, , 2011Chen et al, , 2013Schröder et al, 2007;Ganfornina et al, 2008;Rickhag et al, 2008;Do Carmo et al, 2009a;Jansen et al, 2009;Qin et al, 2010;Bajo-Grañeras et al, 2011a, 2013Delattre et al, 2012;Ordóñez et al, 2012;Germeyer et al, 2013;García-Mateo et al, 2014, 2018Labrie et al, 2015;Martínez-Pinilla et al, 2015;Sanchez et al, 2015;Zheng et al, 2015;…”

Section: Apod Systematic Review Reference Collectionsmentioning

confidence: 99%

“…Reference Collection 26 (Simard et al, 1990(Simard et al, , 1991(Simard et al, , 1992Blais et al, 1994Blais et al, , 1995López-Boado et al, 1994Sugimoto et al, 1994;Do Carmo et al, 2002Sarjeant et al, 2003;Hummasti et al, 2004;Leung et al, 2004;Cha et al, 2006;Tew et al, 2007;Kosacka et al, 2009Kosacka et al, , 2011Sasaki et al, 2009;Bianchi-Frias et al, 2010;Levros et al, 2010;Martínez et al, 2012Martínez et al, , 2013Bajo-Grañeras et al, 2013;Braesch-Andersen et al, 2014;Martínez-Pinilla et al, 2015Martineau et al, 2016;Lai et al, 2017;Pascua-Maestro et al, 2018;Flores et al, 2019;Dassati et al, 2020). Reference Collection 27 (Boyles et al, 1990a;Spreyer et al, 1990;Gillen et al, 1995;Yoshida et al, 1996;Dandoy-Dron et al, 1998;Suresh et al, 1998;Terrisse et al, 1998Terrisse et al, , 1999Franz et al, 1999;Kalman et al, 2000;Trieu and Uckun, 2000;Belloir et al, 2001;Kim et al,...…”

Section: Apod Systematic Review Reference Collectionsunclassified

“…Reference Collection 32 (Albers et al, 1984;Haffner et al, 1985;Holmquist et al, 1993;Gottsch et al, 2003;Zenkel et al, 2005;Flatscher-Bader and Wilce, 2006;Tew et al, 2007;Collins-Racie et al, 2009;Schäfer et al, 2009;Sun et al, 2013;Aregger et al, 2014;Hueging et al, 2015;Kliuchnikova et al, 2016;Starodubtseva et al, 2016;Soria et al, 2017;Deng et al, 2018;Forster et al, 2019;Ponnikorn et al, 2019;Liu et al, 2020). Reference Collection 33 (Bouma et al, 1988;Patel et al, 1995;Navarro et al, 1998Navarro et al, , 2004Suresh et al, 1998;Ong et al, 1999;Hu et al, 2001;Leung et al, 2004;Schröder et al, 2007;Søiland et al, 2009a,b;Ordóñez et al, 2012;Martínez-Pinilla et al, 2015;Klebaner et al, 2017;Pascua-Maestro et al, 2017Schlotter et al, 2020). Reference Collection 34 (Simard et al, 1990(Simard et al, , 1991(Simard et al, , 1992Blais et al, 1994;Patel et al, 1995;Suresh et al, ...…”

Section: Apod Systematic Review Reference Collectionsunclassified

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The Lipocalin Apolipoprotein D Functional Portrait: A Systematic Review

Sánchez

Ganfornina

2021

Front. Physiol.

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Apolipoprotein D is a chordate gene early originated in the Lipocalin protein family. Among other features, regulation of its expression in a wide variety of disease conditions in humans, as apparently unrelated as neurodegeneration or breast cancer, have called for attention on this gene. Also, its presence in different tissues, from blood to brain, and different subcellular locations, from HDL lipoparticles to the interior of lysosomes or the surface of extracellular vesicles, poses an interesting challenge in deciphering its physiological function: Is ApoD a moonlighting protein, serving different roles in different cellular compartments, tissues, or organisms? Or does it have a unique biochemical mechanism of action that accounts for such apparently diverse roles in different physiological situations? To answer these questions, we have performed a systematic review of all primary publications where ApoD properties have been investigated in chordates. We conclude that ApoD ligand binding in the Lipocalin pocket, combined with an antioxidant activity performed at the rim of the pocket are properties sufficient to explain ApoD association with different lipid-based structures, where its physiological function is better described as lipid-management than by long-range lipid-transport. Controlling the redox state of these lipid structures in particular subcellular locations or extracellular structures, ApoD is able to modulate an enormous array of apparently diverse processes in the organism, both in health and disease. The new picture emerging from these data should help to put the physiological role of ApoD in new contexts and to inspire well-focused future research.

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Section: Apod Systematic Review Reference Collectionsmentioning

confidence: 99%

Section: Apod Systematic Review Reference Collectionsunclassified

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The Lipocalin Apolipoprotein D Functional Portrait: A Systematic Review

Sánchez

Ganfornina

2021

Front. Physiol.

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“…Myelinating glia (oligodendrocytes and Schwann cells), mural cells (pericytes), and astrocytes are cell types known to express ApoD in the mammalian nervous system. Adult neurons do not express ApoD but are able to endocytose this protein from the extracellular space, particularly in oxidative stress conditions ( Martínez-Pinilla et al, 2015 ; Pascua-Maestro et al, 2019 ). ApoD-immunoreactive cells with microglial markers have also been found within compact Aβ plaques in patients with Alzheimer’s disease ( Desai et al, 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Dual role of Apolipoprotein D as long-term instructive factor and acute signal conditioning microglial secretory and phagocytic responses

Corraliza-Gomez

Bendito

Sandonis-Camarero

et al. 2023

Front. Cell. Neurosci.

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Microglial cells are recognized as very dynamic brain cells, screening the environment and sensitive to signals from all other cell types in health and disease. Apolipoprotein D (ApoD), a lipid-binding protein of the Lipocalin family, is required for nervous system optimal function and proper development and maintenance of key neural structures. ApoD has a cell and state-dependent expression in the healthy nervous system, and increases its expression upon aging, damage or neurodegeneration. An extensive overlap exists between processes where ApoD is involved and those where microglia have an active role. However, no study has analyzed the role of ApoD in microglial responses. In this work, we test the hypothesis that ApoD, as an extracellular signal, participates in the intercellular crosstalk sensed by microglia and impacts their responses upon physiological aging or damaging conditions. We find that a significant proportion of ApoD-dependent aging transcriptome are microglia-specific genes, and show that lack of ApoD in vivo dysregulates microglial density in mouse hippocampus in an age-dependent manner. Murine BV2 and primary microglia do not express ApoD, but it can be internalized and targeted to lysosomes, where unlike other cell types it is transiently present. Cytokine secretion profiles and myelin phagocytosis reveal that ApoD has both long-term pre-conditioning effects on microglia as well as acute effects on these microglial immune functions, without significant modification of cell survival. ApoD-triggered cytokine signatures are stimuli (paraquat vs. Aβ oligomers) and sex-dependent. Acute exposure to ApoD induces microglia to switch from their resting state to a secretory and less phagocytic phenotype, while long-term absence of ApoD leads to attenuated cytokine induction and increased myelin uptake, supporting a role for ApoD as priming or immune training factor. This knowledge should help to advance our understanding of the complex responses of microglia during aging and neurodegeneration, where signals received along our lifespan are combined with damage-triggered acute signals, conditioning both beneficial roles and limitations of microglial functions.

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“…And ApoC-II can affect the uptake of triglyceride-rich lipoproteins by liver receptors, leading to the formation of human hypertriglyceridemia (Wolska et al, 2017). Moreover, ApoD is up-regulated in several human neurological disorders, such as Alzheimer's disease (AD), Schizophrenia, Parkinson's disease, and multiple sclerosis, and serves as an early diagnostic marker for a variety of cancers and neurological diseases (Martinez-Pinilla et al, 2015). Low level of ApoE in the brain and cerebrospinal fluid is associated with Alzheimer's disease and other neurodegenerative diseases, as well as the early stage of many eye diseases (Mahley, 2016).…”

Section: Introductionmentioning

confidence: 99%

ApoPred: Identification of Apolipoproteins and Their Subfamilies With Multifarious Features

Liu

Chen

Zhang

et al. 2021

Front. Cell Dev. Biol.

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Apolipoprotein is a group of plasma proteins that are associated with a variety of diseases, such as hyperlipidemia, atherosclerosis, Alzheimer’s disease, and diabetes. In order to investigate the function of apolipoproteins and to develop effective targets for related diseases, it is necessary to accurately identify and classify apolipoproteins. Although it is possible to identify apolipoproteins accurately through biochemical experiments, they are expensive and time-consuming. This work aims to establish a high-efficiency and high-accuracy prediction model for recognition of apolipoproteins and their subfamilies. We firstly constructed a high-quality benchmark dataset including 270 apolipoproteins and 535 non-apolipoproteins. Based on the dataset, pseudo-amino acid composition (PseAAC) and composition of k-spaced amino acid pairs (CKSAAP) were used as input vectors. To improve the prediction accuracy and eliminate redundant information, analysis of variance (ANOVA) was used to rank the features. And the incremental feature selection was utilized to obtain the best feature subset. Support vector machine (SVM) was proposed to construct the classification model, which could produce the accuracy of 97.27%, sensitivity of 96.30%, and specificity of 97.76% for discriminating apolipoprotein from non-apolipoprotein in 10-fold cross-validation. In addition, the same process was repeated to generate a new model for predicting apolipoprotein subfamilies. The new model could achieve an overall accuracy of 95.93% in 10-fold cross-validation. According to our proposed model, a convenient webserver called ApoPred was established, which can be freely accessed at http://tang-biolab.com/server/ApoPred/service.html. We expect that this work will contribute to apolipoprotein function research and drug development in relevant diseases.

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Apolipoprotein D subcellular distribution pattern in neuronal cells during oxidative stress

Cited by 8 publications

References 51 publications

The Lipocalin Apolipoprotein D Functional Portrait: A Systematic Review

The Lipocalin Apolipoprotein D Functional Portrait: A Systematic Review

Dual role of Apolipoprotein D as long-term instructive factor and acute signal conditioning microglial secretory and phagocytic responses

ApoPred: Identification of Apolipoproteins and Their Subfamilies With Multifarious Features

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