Apolipoprotein-based regulation of ganglioside metabolism upon secretase activity inhibition in iPSC-derived cerebral organoids
Durga Jha,
Tereza Váňová,
Dáša Bohačiaková
et al.
Abstract:Beta and gamma-secretase inhibitors have been of pharmacological interest to reduce abeta (Aβ) formation and aggregation, a defining characteristic of Alzheimer's disease (AD). Recent research indicates that Apolipoprotein E (ApoE), another genetic risk factor for AD, can regulate secretase activity. Secretase inhibitor-induced elevation of neuronal membrane lipids has been documented in 2D models. Due to their enhanced ability to reproduce AD-like pathology and ease of performing the experimental intervention… Show more
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