Apolipoprotein B signal peptide polymorphism and plasma LDL-cholesterol response to low-calorie diet

Genetic Variation and Atherosclerosis

“…For example, the APOB signal peptide exhibits variability in length (24 or 27 amino acids) due to the insertion ( ins allele) or deletion ( del allele) of three codons [ 51 - 53 ]. The frequency of del allele is about 30% in Caucasians [ 54 ] and has been associated with altered plasma total cholesterol and LDL-C levels in different ethnic groups [ 55 - 60 ] but interestingly not with the risk of vascular diseases [ 54 ]. Thus variation at the apoB gene may act in pathogenesis of vascular diseases through mechanisms not directly related to effects on measured lipid traits.…”

Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study

“…It is likely that genetic variation within the APOB locus explains variable triglyceride lowering with fenofi brate. We examined fi ve SNPs in the APOB gene, three that were previously associated with plasma lipid levels in various contexts ( 21,31,32 ) and two additional APOB SNPs. One of these SNPs (rs679899) was excluded from our analysis because it was not in HWE.…”

Genetic variation and lipid metabolism: Modulation by dietary factors

“…More recently, we have reviewed extensively reviewed this topic including also those studies reported after 2002 [27•,28,29]. Since the submission of those reviews, eight more reports have been added to the pool of interventional gene-diet interaction studies [30][31][32][33][34][35][36][37]. The median of the sample sizes included in these more recent studies is of 57 subjects per study, which highlights one of the traditional problems listed above as the basis for lack of reproducibility.…”