Apolipoprotein B polymorphism distribution among a sample of obese Egyptian females with visceral obesity and its influence on lipid profile

Hassan, Nayera E.; El-Masry, Sahar A.; Zarouk, Waheba A.; Elneam, Ahmed Ibrahim Abd; Rasheed, Enas Abdel; Mahmoud, Maged Mostafa

doi:10.1016/j.jgeb.2015.09.005

Cited by 6 publications

(6 citation statements)

References 36 publications

(38 reference statements)

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“…Therefore, the interactions between APOA1 rs670 and obesity might contribute to low HDL-C diseases, and might increase the risk of low HDL-C diseases. The results are in line with some previous studies [ 30 , 50 – 52 ] which supports the association between ApoA1 gene, obesity and serum HDL-C levels.…”

Section: Discussionsupporting

confidence: 93%

Interactions of six SNPs in APOA1 gene and types of obesity on low HDL-C disease in Xinjiang pastoral area of China

Wang

Guo

et al. 2017

Lipids Health Dis

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BackgroundThis study aims to investigate association between six single nucleotide polymorphisms(SNPs) in APOA1 gene and types of obesity with the risk of low level HDL-C in the pastoral area of northwest China.MethodsA total of 1267 individuals including 424 patients with low HDL-C disease and 843 health subjects were analyzed based on matched for age, sex. SNPShot technique was used to detect the genotypes of rs670, rs5069, rs5072, rs7116797, rs2070665 and rs1799837 in APOA1 gene. The relationship between above six SNPs and types of obesity with low HDL-C disease was analyzed by binary logistic regression.ResultsCarriers with rs670 G allele were more likely to get low HDL-C disease (OR = 1.46, OR95%CI: 1.118–1.915; P = 0.005); The genotypic and allelic frequencies of rs5069, rs5072, rs7116797, rs2070665, rs1799837 revealed no significant differences between cases and controls (P < 0.05); with reference to normal weight, Waist circumference (WC), Waist-to-hip ratio (WHR) individuals, respectively, general obesity measured by BMI had 2.686 times (OR95%CI: 1.695–4.256; P < 0.01), abdominal obesity measured by WC had 1.925 times (OR95%CI: 1.273–2.910; P = 0.002) and abdominal obesity measured by WHR had 1.640 times (OR95%CI: 1.114–2.416; P = 0.012) risk to get low HDL-C disease; APOA1 rs670 interacted with obesity (no matter general obesity or abdominal obesity) on low HDL-C disease.ConclusionsAPOA1 gene may be associated with low HDL-C disease in the pastoral area of northwest China; obesity was the risk factor for low HDL-C disease; the low HDL-C disease is influenced by APOA1, obesity, and their interactions.

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Section: Discussionsupporting

confidence: 93%

Interactions of six SNPs in APOA1 gene and types of obesity on low HDL-C disease in Xinjiang pastoral area of China

Wang

Guo

et al. 2017

Lipids Health Dis

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“…A higher prevalence of atherosclerotic plaques in carotid arteries of T homozygotes has also been reported (13). Some studies have also found association of this polymorphism with CVD, increased apoB, TC, TG, and LDL levels, and decreased HDL levels (5,(14)(15)(16)(17). On the other hand, some studies found no association between these parameters (9,11,18).…”

Section: Introductionmentioning

confidence: 95%

“…The literature consistently reassures the association between dyslipidemia and incidence of vascular events, with strong etiological contribution by increased triglyceride (TG), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and apolipoprotein B (apoB) levels, as well as by reduction of high-density lipoprotein (HDL) levels (4,5). With subendothelial retention of apolipoprotein(apo)B-containing particles as a necessary trigger for atherogenesis, levels of this apolipoprotein present predictive power for vascular events as high as those of LDL (6,7).…”

Section: Introductionmentioning

confidence: 99%

The APOB rs693 polymorphism impacts the lipid profile of Brazilian older adults

Alves

Henriques

Furioso

et al. 2020

Braz J Med Biol Res

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The apolipoprotein B (APOB) gene contains several polymorphic sites described as risk modifiers for cardiovascular events. The objective of this study was to verify the association of the classic APOB Xba I polymorphism (rs693) with atherosclerotic risk factors in a segment of the Brazilian elderly population considering their usual dietary intake. Clinical and biochemical characteristics as well as total caloric and fat intake data were determined from 644 elderly individuals. Polymorphism analysis was performed by conventional polymerase chain reaction followed by enzyme restriction. Statistical analyses compared measures and proportions according to different APOB genotypic combinations. Statistically significant association was found between Xba I polymorphism and serum LDL, total cholesterol, and total lipid levels, with important elevations among T homozygotes compared to the other genotypes. There was homogeneity in all other parameters analyzed (including intake pattern), with a tendency for reduced levels of circulating apolipoprotein B among TT individuals. Our results pointed out that genetic variation in APOB affected the lipemic profile of elderly individuals in a context not biased by diet, generating a pattern suggestive of secretory disorder of lipoprotein particles, with possible implication in atherosclerotic risk.

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“… 28 Apo B mutations may favor liver absorption of dietary fats or VLDL secretion. 29 Apo B mutations also result in altered association with capillary lipoprotein lipase, which favors triglyceride hydrolysis and fat deposition. Some previous studies have found that Apo B levels are stronger risk factors for obesity than LDL.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors of Comorbid Obesity in Chinese Patients with Bipolar Disorder

Wu¹,

Zhang²,

Liu³

et al. 2023

DMSO

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Purpose Bipolar disorder (BD) predisposes patients to comorbid obesity and increases the risk of metabolic syndrome and cardiovascular disease. In this study, we investigated the prevalence of comorbid obesity and its risk factors in patients with BD in China. Patients and Methods We conducted a cross-sectional retrospective survey of 642 patients with BD. Demographic data were collected, physical examinations were performed, and biochemical indexes, including fasting blood glucose, alanine aminotransferase (ALT), aspartate aminotransferase, and triglycerides (TG) levels, were measured. Height and weight were measured on an electronic scale at admission, and body mass index (BMI) was in kg/m 2 . Pearson’s correlation analysis was used to analyze the correlation between BMI and variable indicators. Multiple linear regression analysis was used to analyze the risk factors for comorbid obesity in patients with BD. Results The prevalence of comorbid obesity in Chinese patients with BD was 21.3%. Obese patients had high levels of blood glucose, ALT, glutamyl transferase, cholesterol, apolipoprotein B (Apo B), TG, and uric acid in the plasma; however, the levels of high-density lipoprotein and apolipoprotein A1 were lower than those in non-obese patients. Partial correlation analysis showed that BMI was associated with ApoB, TG, uric acid, blood glucose, GGT, TC, ApoA1, HDL, and ALT levels. Multiple linear regression showed that ALT, blood glucose, uric acid, TG, and Apo B levels were important risk factors of BMI. Conclusion The prevalence of obesity is higher in patients with BD in China, and TG, blood glucose, liver enzymes, and uric acid are closely related to obesity. Therefore, more attention should be paid to patients with comorbid obesity. Patients should be encouraged to increase their physical activity, control sugar and fat intake, and reduce the prevalence of comorbid obesity and risk of serious complications.

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Apolipoprotein B polymorphism distribution among a sample of obese Egyptian females with visceral obesity and its influence on lipid profile

Cited by 6 publications

References 36 publications

Interactions of six SNPs in APOA1 gene and types of obesity on low HDL-C disease in Xinjiang pastoral area of China

Interactions of six SNPs in APOA1 gene and types of obesity on low HDL-C disease in Xinjiang pastoral area of China

The APOB rs693 polymorphism impacts the lipid profile of Brazilian older adults

Prevalence and Risk Factors of Comorbid Obesity in Chinese Patients with Bipolar Disorder

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