Apolipoprotein B gene polymorphisms g.2488C&gt;T and g.4154G&gt;A are not associated with coronary artery disease in a Brazilian population

Anghebem-Oliveira, Mauren Isfer; Picheth, Geraldo; Prochaska, Caroline Luise; Scartezini, Mariléia; Costantini, Costantino O.; Souza, Emanuel M.; Pedrosa, Fábio O.

doi:10.1016/j.cca.2009.01.010

Cited by 4 publications

(3 citation statements)

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“…The association between apo B gene polymorphisms and the risk of CHD has been widely studied, but the results remain inconclusive. 11 –64 For example, Baroni et al reported a significant difference in the development of CHD between genotype classes of the XbaI polymorphism in an Italian population. 13 Duman et al did not observe significant differences in the frequencies of apo B XbaI (CC, CT, TT) and EcoRI (AA, AG, GG) genotypes between case and control subjects in Turkish.…”

Section: Discussionmentioning

confidence: 99%

Association between apolipoprotein B gene polymorphisms and the risk of coronary heart disease (CHD): an update meta-analysis

Zhang

Zheng

Yang

et al. 2015

J Renin Angiotensin Aldosterone Syst

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Objective: Polymorphisms in the apolipoprotein B (apoB) gene have been reported to be associated with coronary heart disease (CHD). However, the results on this topic are conflicting. The present study aims to derive a more precise estimation of the relationship between CHD and apoB genetic polymorphisms by meta-analysis. Methods:We identified a total of 54 studies involving 7236, 10,912, and 14,102 individuals, respectively, for EcoRI, XbaI, and SpIns/Del polymorphisms by searching in PubMed, Web of Science, Google Scholar, the Cochrane Library, Wanfang Data, SinoMed, and CNKI. We utilized RevMan 5.0 software to perform the meta-analyses. Results: A significant statistical association between apoB EcoRI polymorphism and CHD was observed under an allelic (p = 0.001, odds ratio (OR) = 1.33, 95% confidence interval (CI) = 1.12-1.57), dominant (p = 0.005, OR = 1.22, 95% CI = 1.06-1.40), and recessive (p = 0.04, OR = 1.33, 95% CI = 1.01-1.74) model. We also found similar association of apoB SpIns/Del polymorphism with CHD. However, we did not find association between apoB XbaI polymorphism and CHD. Conclusion:The current meta-analysis found an association of EcoRI polymorphism and SpIns/Del polymorphism with an increased risk of CHD. No significant association between apoB XbaI polymorphism and CHD we observed in the present study.

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Section: Discussionmentioning

confidence: 99%

Association between apolipoprotein B gene polymorphisms and the risk of coronary heart disease (CHD): an update meta-analysis

Zhang

Zheng

Yang

et al. 2015

J Renin Angiotensin Aldosterone Syst

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“…The results showed that single haplotype X + Del in apo B gene has an effect on lipid metabolism and may contribute to the susceptibility to development of CHD among Brazilian men. Similarly, there are another two studies on the Brazilian population included studies by Luis A. Salazar [21] and Anghebem-Oliveira, MI, [22] but the conclusions were inconsistent. The former showed that the Apo B gene polymorphism was associated with Brazilian Caucasian CAD, and the latter had nothing to do with it.…”

Section: Discussionmentioning

confidence: 99%

Association between apolipoprotein B XbaI polymorphisms and coronary heart disease: A meta-analysis

Feng

Chen

Liu

et al. 2020

BMC Cardiovasc Disord

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Background: To evaluate the association between apolipoprotein B gene polymorphism and coronary heart disease in some populations at home and abroad by means of meta-analysis. Methods: Using the strict exclusion criteria for primary screening of the literature and applying the Hardy-Weinberg equilibrium to test the genetic balance of the selected literature. The corresponding models were selected according to the results of the heterogeneity test. The Begg's test and Egger's test were used to evaluate publication bias, and meta-analysis was performed using Stata 12.0. Results: The study included twelve articles. In the literature, a total of 1596 patients with coronary heart disease and 1431 controls.Meta-analysis results showed no statistical value in the following three genetic models: allelic comparison (a vs A,P = 0.811,OR = 0.95, 95%CI = 0.62-1.46), recessive genetic models (aa vs Aa/AA, P = 0.86,OR = 0.94, 95%CI = 0.45-1.96), or dominant genetic models (aa/Aa vs AA, P = 0.73,OR = 0.92, 95%CI = 0.58-1.47). Subgroup analysis based on ethnicity showed allelic comparison (a vs A,P = 0.464,OR = 1.32, 95%CI = 0.63-2.78), recessive genetic models (aa vs Aa/ AA, P = 0.422,OR = 1.52, 95%CI = 0.55-4.21), and dominant genetic models (aa/Aa vs AA, P = 0.551,OR = 1.26, 95%CI = 0.58-2.73) in Asians, allelic comparison (a vs A,P = 0.410,OR = 0.79, 95%CI = 0.45-1.39), recessive genetic models (aa vs Aa/AA, P = 0.041,OR = 0.75,95%CI = 0.57-0.99),dominant genetic models (aa/Aa vs AA, P = 0.385,OR = 0.75, 95%CI = 0.40-1.43) in Caucasian; Conclusion: The ApoB(apolipoprotein B) XbaI locus is not a risk factor when it comes to the development of coronary heart disease in the domestic and international populations included in this paper. In Caucasians, people carrying the aa genotype may be less susceptible to CHD (coronary heart disease). The results of recessive genetic models have to take the effect of heterogeneity and sample sizes into account. Further research may require a larger and more rigorous research design.

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“…The main characteristics of the included studies are listed in Table (1a, 1b, 1c, 1d, in Supplementary document). A total of 47 eligible studies (Aburatani et al 1987;Al-Bustan et al 2009;Anghebem-Oliveira et al 2009;Beneš et al 2000a, b;Berkinbayev et al 2014;Bohn et al 1993Bohn et al , 1994Buraczynska et al 2000;Corbo et al 1997;De Lorenzo et al 1993;de Padua Mansur et al 2000;Duman et al 2005;Dunning et al 1993;Ferns and Galton 1986;Gallegos-Arreola et al 2012;Gardemann et al 1998;Genest et al 1990;Hegele et al 1986;Hong et al 2001;Hosking et al 1992;Huang et al 2012;Kallel et al 2008;Machado et al 2001;Marshall et al 1994;Mendis et al 1991;Miettinen et al 1994;Myant et al 1989;Nieminen et al 1992;Pan et al 1995;Paulweber et al 1990;Rebhi et al 2008;Saha et al 1992;Salazar et al 2000;Scartezini et al 2003;Stepanov et al 1998;Tybjaerg-Hansen et al 1991;Visvikis et al 1993;Wiklund et al 1989;Wu et al 1994;Xu and Zhou 1998;…”

Section: Characteristics Of the Eligible Studiesmentioning

confidence: 98%

Four Apolipoprotein B gene polymorphisms and the risk for coronary artery disease: a meta-analysis of 47 studies

et al. 2015

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Apolipoprotein B plays a central role in lipoprotein metabolism. Many studies have evaluated the association between Apolipoprotein B gene polymorphisms (XbaI, EcoRI, SpIns/Del, MspI) and the risk for coronary artery disease and myocardial infarction. However, the results remain inconsistent, particularly among different populations. To more precisely determine the association between Apolipoprotein B gene polymorphisms and coronary artery disease/myocardial infarction risk, we performed a meta-analysis via a comprehensive search of electronic databases (up to February 1st, 2015), odds ratios (OR) and 95 % confidence intervals were calculated using a fixed or random effect model. A total of 47 studies, with 9411 coronary artery disease/myocardial infarction cases and 9082 controls, were included in this meta-analysis. The combined results revealed significant associations between an increased risk of coronary artery disease/myocardial infarction and EcoRI (AA vs GG: OR 1.511, 95 % confidence interval (CI) 1.098, 2.078) and SpIns/Del (DD vs II: OR 1.331, 95 % CI 1.064, 1.665) alleles in the general population. In a subgroup analysis stratified by ethnicity, the T allele of the XbaI variant was associated with a decreased risk in Caucasians, whereas it was associated with an increased risk among the East Asian population. No significant correlation was detected between the A allele of the MspI variant and the coronary artery disease/myocardial infarction risk in either the general population or any ethnic subgroup. The results of our study suggest that Apolipoprotein B gene polymorphisms may affect the coronary artery disease/myocardial infarction susceptibility and these effects may display notable discrepancies among different populations.Keywords Apolipoprotein B Á Polymorphism Á Coronary artery disease Á Myocardial infarction Á Meta-analysis Electronic supplementary material The online version of this article (

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Apolipoprotein B gene polymorphisms g.2488C>T and g.4154G>A are not associated with coronary artery disease in a Brazilian population

Cited by 4 publications

References 7 publications

Association between apolipoprotein B gene polymorphisms and the risk of coronary heart disease (CHD): an update meta-analysis

Association between apolipoprotein B gene polymorphisms and the risk of coronary heart disease (CHD): an update meta-analysis

Association between apolipoprotein B XbaI polymorphisms and coronary heart disease: A meta-analysis

Four Apolipoprotein B gene polymorphisms and the risk for coronary artery disease: a meta-analysis of 47 studies

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