Apolipoprotein B gene 3′VNTR polymorphism: association with plasma lipids and coronary heart disease in Han Chinese

“…APOB 3ʹ-VNTR alleles with relatively larger number of repeats have association with a number of disease conditions. Alleles with higher repeats (≥36 repeats) were shown to be strongly correlated with coronary heart disease 18,[33][34][35] . APOB 3ʹ-VNTR alleles with higher repeats are also significantly associated with higher levels of total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) 36,37 .…”

Section: Discussionmentioning

confidence: 99%

Association of APOB 3ʹ-VNTR alleles with type 2 diabetes, BMI, systolic and diastolic blood pressure

Sajib

Khan

Haque

et al. 2018

Bangladesh J Med Sci

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Background: Apolipoprotein B (APOB) is a component of chylomicrons, low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), intermediate density lipoproteins (IDL) and functions as the main protein for transporting cholesterol to peripheral cells. APOB gene has an AT-rich VNTR site at its 3ʹ-untranslated region (3ʹ-UTR). APOB 3ʹ-VNTR alleles with ≥36 repeats have been shown to be strongly associated with increased serum lipid levels, gallstone formation and coronary artery disease. Objectives: To investigate any possible association of APOB 3ʹ-VNTR alleles with type 2 diabetes, BMI, systolic and diastolic blood pressure. Materials and methods: APOB 3ʹ-VNTR region in the DNA of non-diabetic controls and type 2 diabetic patients were amplified by polymerase chain reaction (PCR) and the numbers of core repeat in the amplified products were determined. Frequencies of the APOB alleles and genotypes among the controls and the patients were calculated and statistical analyses were performed. Results and discussion: Here we report for the first time that APOB 3ʹ-VNTR alleles have different distribution frequencies among type 2 diabetic and non-diabetic individuals. We also observed higher body mass index (BMI), systolic and diastolic blood pressures in individuals who had at least one APOB 3ʹ-VNTR allele with ≥35 repeats. Conclusion: Our study might bridge among the genetic signature of APOB 3ʹ-VNTR, high APOB protein level in blood, diabetes and other co-morbidities.

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“…Several restriction fragment length polymorphisms (RFLP) and variable number of tandem repeats (VNTR) polymorphisms have also been described within APOB coding as well as 3’-untranslated region (3’-UTR), [ 66 , 67 ]. Studies examining the association of these common genetic variations in APOB with atherosclerosis have led to inconsistent findings [ 68 - 72 ].…”

Section: Genetic Variants In Lipoprotein Metabolismmentioning

confidence: 99%

Genetic Variation and Atherosclerosis

Biroš

Karan²,

Golledge³

2008

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A family history of atherosclerosis is independently associated with an increased incidence of cardiovascular events. The genetic factors underlying the importance of inheritance in atherosclerosis are starting to be understood. Genetic variation, such as mutations or common polymorphisms has been shown to be involved in modulation of a range of risk factors, such as plasma lipoprotein levels, inflammation and vascular calcification. This review presents examples of present studies of the role of genetic polymorphism in atherosclerosis.

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Apolipoprotein B gene 3′VNTR polymorphism: association with plasma lipids and coronary heart disease in Han Chinese

Abstract: APOB gene 3'VNTR polymorphism exerts an impact on lipid metabolism and may contribute to the susceptibility to the development of CHD in Han Chinese.

Cited by 4 publications

References 20 publications

5′ ins/del and 3′ VNTR polymorphisms in the apolipoprotein B gene in relation to lipids and coronary artery disease

5′ ins/del and 3′ VNTR polymorphisms in the apolipoprotein B gene in relation to lipids and coronary artery disease

Association of APOB 3ʹ-VNTR alleles with type 2 diabetes, BMI, systolic and diastolic blood pressure

Genetic Variation and Atherosclerosis

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