Apolipoprotein B as a Marker of Familial Hyperlipoproteinemia

Abstract

Aims: Families with 10-12-year-old schoolchildren were informed about and asked to participate in a study to identify children with hyperlipoproteinemia. We hypothesised that children and families with familial blood lipid abnormalities, specifically those with familial hypercholesterolemia (FH) and familial combined hyperlipidemia (FCHL), could be identified by the child's apolipoprotein B level exceeding the 95th percentile. Methods: Written information and consent was distributed to the families. Families whose child had an apoB concentration exceeding the 95th percentile were further examined. Children and parents were divided into normal, high and very high low density lipoprotein cholesterol (LDLC) groups. In adults a high LDLC level was defined as

What matters most in pediatric familial hypercholesterolemia, genotype or phenotype?

“…Thus it is premature, based on this study, to include such a ratio as it is likely very different ratios would be obtained in different laboratories. Certainly the use of apoB has been suggested as a better marker for FH in children than LDL-C ( 14 ).…”

Asociación genética de polimorfismos en el gen APOB (rs5247904) y citocinas proinflamatorias en hipercolesterolemia familiar

“…de las personas que pueden sufrir enfermedad prematura coronaria. (Sveger, 2004) Los niveles de la LDL están asociados con un aumento del riesgo de enfermedades cardiovasculares y evento cerebro vascular (ECV). Estudios recientes sugieren que un 40% a 80% de la variación en los niveles de LDL de la población es atribuible a factores genéticos.…”