Apolipoprotein A-IV Levels and Phenotype Distribution in NIDDM

Vergès, Bruno; Vaillant, G.; Goux, Alain; Lagrost, Laurent; Brun, J; Gambert, Philippe

doi:10.2337/diacare.17.8.810

Cited by 22 publications

(19 citation statements)

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“…Interestingly, APOA-IV levels were significantly higher in T2DM patients before the diet as compared to controls, which was also found in earlier studies [37],[38]. In contrast to our study, some also showed higher APOA-IV levels in obese, non-diabetic mice and humans [39],[40], though others did not find an association between APOA-IV and BMI [41].…”

Section: Discussionsupporting

confidence: 74%

Proteomic Analysis in Type 2 Diabetes Patients before and after a Very Low Calorie Diet Reveals Potential Disease State and Intervention Specific Biomarkers

et al. 2014

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Very low calorie diets (VLCD) with and without exercise programs lead to major metabolic improvements in obese type 2 diabetes patients. The mechanisms underlying these improvements have so far not been elucidated fully. To further investigate the mechanisms of a VLCD with or without exercise and to uncover possible biomarkers associated with these interventions, blood samples were collected from 27 obese type 2 diabetes patients before and after a 16-week VLCD (Modifast ∼450 kcal/day). Thirteen of these patients followed an exercise program in addition to the VCLD. Plasma was obtained from 27 lean and 27 obese controls as well. Proteomic analysis was performed using mass spectrometry (MS) and targeted multiple reaction monitoring (MRM) and a large scale isobaric tags for relative and absolute quantitation (iTRAQ) approach. After the 16-week VLCD, there was a significant decrease in body weight and HbA1c in all patients, without differences between the two intervention groups. Targeted MRM analysis revealed differences in several proteins, which could be divided in diabetes-associated (fibrinogen, transthyretin), obesity-associated (complement C3), and diet-associated markers (apolipoproteins, especially apolipoprotein A-IV). To further investigate the effects of exercise, large scale iTRAQ analysis was performed. However, no proteins were found showing an exercise effect. Thus, in this study, specific proteins were found to be differentially expressed in type 2 diabetes patients versus controls and before and after a VLCD. These proteins are potential disease state and intervention specific biomarkers.Trial RegistrationControlled-Trials.com ISRCTN76920690

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Section: Discussionsupporting

confidence: 74%

Proteomic Analysis in Type 2 Diabetes Patients before and after a Very Low Calorie Diet Reveals Potential Disease State and Intervention Specific Biomarkers

et al. 2014

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“…ApoA-IV exerts a strong anti-atherogenic effect [17] and has also been suggested to act as a satiety factor. Plasma apoA-IV is elevated in human type 2 diabetes and obesity and decreases during weight reduction [18,19].…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein AV does not contribute to hypertriglyceridaemia or triglyceride lowering by dietary fish oil and rosiglitazone in obese Zucker rats

Dorfmeister

Brandlhofer

Schaap³

et al. 2006

Diabetologia

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“…The increased expression of APOA4 was found in chronic kidney disease (CKD) patients [21]. In previous studies, plasma APOA4 levels were increased in DM patients, especially in noninsulin-dependent diabetes mellitus (NIDDM) patients [22, 23].…”

Section: Resultsmentioning

confidence: 99%

Proteomic Profiling for Peritoneal Dialysate: Differential Protein Expression in Diabetes Mellitus

Yang

Wang

et al. 2013

BioMed Research International

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Peritoneal dialysis (PD) is an increasingly accepted modality of renal replacement therapy. It provides the advantages of having a flexible lifestyle, stable hemodynamics, and better preservation of residual renal function. To enhance our understanding of the peritoneal dialysate of diabetes mellitus (DM), peritoneal dialysate proteins were identified by two-dimensional gel electrophoresis (2DE) combined with reverse-phase nano-ultra performance liquid chromatography electrospray ionization tandem mass spectrometry (RP-nano-UPLC-ESI-MS/MS) followed by peptide fragmentation patterning. To validate the differential proteins, ELISA and Western blotting analyses were applied to detect candidate proteins that may be related to DM. We performed 2DE on the peritoneal dialysate samples, with detection of more than 300 spots. From this, 13 spots were excised, in-gel digested, and identified by RP-nano-UPLC-ESI-MS/MS. Ten of these showed significant differential expression between the DM and chronic glomerulonephritis (CGN) peritoneal dialysate samples. In this study, we conducted a comparative proteomic study on these two groups of dialysate that may provide evidence for understanding the different peritoneal protein changes. These proteins may not be new biomarkers; however, they may indicate a situation for possible drug treatment and can be the predictors of peritonitis for a validation study in the future.

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Apolipoprotein A-IV Levels and Phenotype Distribution in NIDDM

Cited by 22 publications

References 0 publications

Proteomic Analysis in Type 2 Diabetes Patients before and after a Very Low Calorie Diet Reveals Potential Disease State and Intervention Specific Biomarkers

Proteomic Analysis in Type 2 Diabetes Patients before and after a Very Low Calorie Diet Reveals Potential Disease State and Intervention Specific Biomarkers

Apolipoprotein AV does not contribute to hypertriglyceridaemia or triglyceride lowering by dietary fish oil and rosiglitazone in obese Zucker rats

Proteomic Profiling for Peritoneal Dialysate: Differential Protein Expression in Diabetes Mellitus

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