Apolipoprotein A-I conformation markedly influences HDL interaction with scavenger receptor BI

Beer, Maria C. de; Durbin, Diane M.; Cai, Lei; Jonas, Alain M.; Beer, Frederick C. de; Westhuyzen, Deneys R. van der

doi:10.1016/s0022-2275(20)31693-x

Cited by 97 publications

(31 citation statements)

References 21 publications

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“…The facts that HDL consists of particles of varying sizes and different lipid and protein compositions and densities (54), and that apoA-I is the principal component of HDL, are in accordance with observations that the physical characteristics of HDL as well as the conformation/organization of apoA-I in HDL particles are critical for optimal binding of HDL to SR-B1 (38). Indeed, it has been demonstrated that spherical -HDL particles, which are larger in size, cholesterol rich, and lower density, bind more strongly to SR-B1 as compared with high-density lipid-poor pre-HDL (55,56). Interestingly, reconstituted discoidal apoA-I complexes bind SR-B1 with even much greater affinity than native -HDL (55).…”

Section: Sr-b1 Ligandssupporting

confidence: 88%

Thematic Review Series: Lipid Transfer Proteins Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function

Shen

Asthana

Kraemer

et al. 2018

Journal of Lipid Research

103

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Cholesterol is required for maintenance of plasma membrane fluidity and integrity and for many cellular functions. Cellular cholesterol can be obtained from lipoproteins in a selective pathway of HDL-cholesteryl ester (CE) uptake without parallel apolipoprotein uptake. Scavenger receptor B type 1 (SR-B1) is a cell surface HDL receptor that mediates HDL-CE uptake. It is most abundantly expressed in liver, where it provides cholesterol for bile acid synthesis, and in steroidogenic tissues, where it delivers cholesterol needed for storage or steroidogenesis in rodents. SR-B1 transcription is regulated by trophic hormones in the adrenal gland, ovary, and testis; in the liver and elsewhere, SR-B1 is subject to posttranscriptional and posttranslational regulation. SR-B1 operates in several metabolic processes and contributes to pathogenesis of atherosclerosis, inflammation, hepatitis C virus infection, and other conditions. Here, we summarize characteristics of the selective uptake pathway and involvement of microvillar channels as facilitators of selective HDL-CE uptake. We also present the potential mechanisms of SR-B1-mediated selective cholesterol transport; the transcriptional, posttranscriptional, and posttranslational regulation of SR-B1; and the impact of gene variants on expression and function of human SR-B1. A better understanding of this unique pathway and SR-B1's role may yield improved therapies for a wide variety of conditions.

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Section: Sr-b1 Ligandssupporting

confidence: 88%

Thematic Review Series: Lipid Transfer Proteins Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function

Shen

Asthana

Kraemer

et al. 2018

Journal of Lipid Research

103

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“…The increased catabolism of medium HDL is likely explained by a unique conformation of apoA-I on the sur-face of the HDL particles or to an increase in the fluidity of the phospholipid surface. A recent study demonstrated that large HDL compared with small HDL were bound to scavenger receptor BI on the surface of CHO cells with higher affinity, and the authors concluded that HDL size and/or apoA-I conformation influences the binding of HDL subfractions to scavenger receptor BI (52). We have previously shown that recombinant HDL made with phosphatidylcholine containing n-3 fatty acids (docosahexanoic and eicosapentaenoic acid) in the sn-2 position have apoA-I that is in a different conformation and has a decreased stability compared with particles containing phosphatidylcholine with oleic acid in the sn-2 position (53).…”

Section: Discussionmentioning

confidence: 99%

Dietary n-3 polyunsaturated fat increases the fractional catabolic rate of medium-sized HDL particles in African green monkeys

Huggins

Colvin

Burleson

et al. 2001

Journal of Lipid Research

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We have previously described a novel pathway for the metabolism of HDL subfractions in which small [2 apolipoprotein (apoA-I) molecules per particle] HDL particles are converted in a unidirectional manner outside the plasma compartment to medium (3 apoA-I molecules per particle) or large (4 apoA-I molecules per particle) HDL particles, which are subsequently removed from the circulation by the liver (Colvin et al. 1999.

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“…The potential interaction of apoA-I with eNOS in cultured endothelial cells has been previously reported . However, lipid-free apoA-I failed to activate eNOS despite being the ligand for SR-BI, suggesting that other HDL components may be important or are required to support the conformation of apoA-I to allow its interaction with SR-BI and to stimulate eNOS (de Beer et al 2001). In isolated endothelial cell plasma membranes, anti-apoA-I antibody blocks eNOS activation by HDL in vitro .…”

Section: Mechanisms Under Physiological Conditionsmentioning

confidence: 99%

High Density Lipoproteins

Rj²,

Jw³

2015

Handbook of Experimental Pharmacology

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The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein.

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Apolipoprotein A-I conformation markedly influences HDL interaction with scavenger receptor BI

Cited by 97 publications

References 21 publications

Thematic Review Series: Lipid Transfer Proteins Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function

Thematic Review Series: Lipid Transfer Proteins Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function

Dietary n-3 polyunsaturated fat increases the fractional catabolic rate of medium-sized HDL particles in African green monkeys

High Density Lipoproteins

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