Apolipoprotein A-I

Sveger, Tomas; Fex, Göran; Flodmark, Carl‐Erik; Kjellström, Thomas; Borgfors, Nils

doi:10.1097/00005176-199002000-00006

Cited by 4 publications

(1 citation statement)

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“…The ApoB analysis is relevant for improvement of CV risk detection, as ApoB evidence demonstrates. Serum analysis has been considered in children since the 1990s, formerly as a candidate marker to screen for FH affected subjects [22,23], then to distinguish other dyslipidemias in subjects carrying ApoB exceeding 100 mg/dL levels [24].…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein B and Lipid Profile in Italian Children and Adolescents

Martino,

Niglio,

Martino

et al. 2024

JCDD

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Rationale. The prevention of cardiovascular (CV) disease is mandatory from childhood onwards. Among biochemical markers related to the clinical cardiovascular outcome, LDL cholesterol (LDL-C), non-HDL-C and apolipoprotein B (ApoB) are recognized as main target parameters. Emphasis on ApoB concentrations is growing, as representative of any class of atherogenic lipoprotein. This consideration allows checking of subjects under 18 years of age when the CV risk occurs. The aim of this study is to evaluate ApoB levels in a sample of Italian hyperlipidemic children and adolescents, and their siblings, to test any relationship with their lipid profile. Methods. A retrospective study, including 1877 children and adolescents (aged 0–18 years), was performed. Clinical and biochemical data were selected from a database, including the lipid profile, ApoB analysis and anthropometric parameters of any proband. Participants had been checked as potentially hyperlipidemia affected, the suspicion raised by familial CV risk or because the dyslipidemia was already known. Data from the first visit at the University Hospitals in Rome and Turin were collected. Patients affected by secondary hyperlipidemia or obesity were excluded. Blood test analysis was performed in fasting conditions by automated commercial kits. Participants were classified according to gender, age (stratified in subgroups: 0–5, 6–10, 11–14, and 15–18 years old) and anthropometric parameters, referred to as weight in Kg and height in cm, and BMI calculated. Lipid profile results were stratified in relation to acceptable, borderline, or increased levels, as indicated by NCEP, and any potential relation with ApoB established. Statistics were performed by Epi-Info 7 programs to evaluate the variance analysis. Either parent could sign the informed consent. Results. Among the whole sample n.1010 and n.867 participants were females and males, respectively. TC values acceptable (≤170 mg/dL), borderline (171–200 mg/dL) and elevated (≥201 mg/dL) were found in 411 (22%), 585 (31%) and 881 (47%) participants, respectively. The LDL-C cut-off considered was 110 mg/dL (90° percentile). Mean ApoB progressively increased from 65 to 110 mg/dL according to TC levels and resulted in significant correlation when any age subgroup and gender was considered. The highest ApoB values, TC and LDL-C related, were found in the youngest subgroup, regardless of gender. Conclusion. ApoB results increase progressively and in parallel with TC and LDL-C and represent a further parameter to distinguish between normal and hyperlipidemic subjects. Serum levels are close to 70 mg/dL and to 100 mg/dL in the former and latter group, respectively.

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Section: Discussionmentioning

confidence: 99%

Apolipoprotein B and Lipid Profile in Italian Children and Adolescents

Martino,

Niglio,

Martino

et al. 2024

JCDD

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Usefulness of Serum Apolipoprotein B Levels for Screening Children With Primary Dyslipoproteinemias

Sarrı́a

Moreno²,

Mur³

et al. 1992

Arch Pediatr Adolesc Med

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An efficient screening procedure detecting six novel mutations in the LDL receptor gene in Swedish children with hypercholesterolemia

et al. 1995

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Familial hypercholesterolemia (FH) is an autosomal semi-dominant disorder caused by defects in the low density lipoprotein receptor (LDLR) gene and is a well-documented risk factor for developing cardiovascular disease. The LDLR genes of five Swedish children with FH were examined in this study. Initial mutation screening was performed by denaturing gradient gel electrophoresis (DGGE) with enzymatically amplified exon-sized fragments, each containing a tailing GC-rich requence. The GC-clamped fragments had been synthesized with a restriction site adjacent to the intron-corresponding sequence to allow detachment of the clamps, thereby rendering the fragments suitable for subsequent analysis by single-strand conformation polymorphism (SSCP) analysis of samples from patients with no DGGE-detectable mutations. In addition, all the LDLR genes of the patients were screened for large alterations by restriction fragment length polymorphism analysis. Following this strategy, seven different, potentially disease-causing mutations were detected in the five children with FH. Six of the alterations, five single-base substitutions and one dinucleotide deletion, have not previously been described. DGGE detected six of the mutations and SSCP the seventh.

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Apolipoprotein A-I

Cited by 4 publications

References 0 publications

Apolipoprotein B and Lipid Profile in Italian Children and Adolescents

Apolipoprotein B and Lipid Profile in Italian Children and Adolescents

Usefulness of Serum Apolipoprotein B Levels for Screening Children With Primary Dyslipoproteinemias

An efficient screening procedure detecting six novel mutations in the LDL receptor gene in Swedish children with hypercholesterolemia

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